Liver-Directed mRNA Delivery Restores Immune Function in Ageing
Ageing is associated with progressive decline in immune function, leading to increased susceptibility to infections, reduced vaccine efficacy, and diminished responses to cancer immunotherapy. This immune deterioration arises from a reduced capacity to generate new immune cells and the gradual accumulation of dysfunctional and exhausted immune cell states. Thymic involution, which starts early in childhood […]
Growing up with screens: Investigating gender and socioeconomic differences and social relationships in the development of problematic smartphone use
J Res Adolesc. 2025 Dec;35(4):e70116. doi: 10.1111/jora.70116. ABSTRACT The present study investigated the longitudinal trajectory of adolescents’ problematic smartphone use (PSU) from Grade 4 to Grade 8. We also examined whether the trajectory differs depending on student gender, parent educational attainment, and family income, and whether prior and concurrent social relationships predict adolescents’ PSU at […]
Improvement in Quality of Life After Early Interactive Human Coaching via a Mobile App in Postgastrectomy Patients With Gastric Cancer: Prospective Randomized Controlled Trial
JMIR Mhealth Uhealth. 2025 Dec 18;13:e75445. doi: 10.2196/75445. ABSTRACT BACKGROUND: Patients undergoing gastrectomy usually experience postgastrectomy syndrome and face difficulties adapting to a regular diet. Human health coaching via a mobile app has recently been applied to patients with chronic metabolic diseases, with significant improvements being observed in clinical outcomes. OBJECTIVE: This study aimed to […]
A Milestone Moment: FDA Approves Addyi® for Hypoactive Sexual Desire Disorder in Postmenopausal Women
Addyi® (flibanserin) is the first Food and Drug Administration (FDA) approved pill for low sexual desire in women. It is manufactured by Sprout Pharmaceuticals. It is now approved for the treatment of hypoactive sexual desire disorder (HSDD) in women under 65 years of age, including postmenopausal women. This decision addresses a long-standing research gap in […]
Birds Could Help Scientists Better Understand Human Mental Disorders
Researchers are increasingly exploring alternatives to traditional laboratory animals to gain deeper insights into the human brain. According to a recent scientific review, birds may offer valuable insights into human mental disorders, particularly those related to stress, mood, and cognition. For decades, neuroscience research has relied heavily on rats and mice. However, these animals are […]
ROOM to Grow, a Mobile Well-Being Intervention for University Students: Overview of the Design Process and Outcomes
JMIR Form Res. 2025 Dec 17;9:e63325. doi: 10.2196/63325. ABSTRACT BACKGROUND: University students are facing a multitude of challenges and an increase in mental health issues that affect their academic performance and overall well-being. In response, Erasmus University Rotterdam launched the Student Wellbeing Programme in 2019, offering comprehensive, tailored support through a stepped-care framework to enhance […]
Enhancing Parenting Using AI: Exploratory Hackathon
JMIR Form Res. 2025 Dec 17;9:e68780. doi: 10.2196/68780. ABSTRACT BACKGROUND: Parenting skills programs are the primary intervention for conduct disorders in children. The Pause app enhances these programs by providing digital microinterventions that reinforce learning between sessions and after program completion. The potential of artificial intelligence (AI) in this context remains untapped. Hackathons have proven […]
Workplace sexual harassment and post-traumatic stress disorder symptoms in nurses: a cross-sectional study in southeast Iran
BMJ Open. 2025 Dec 17;15(12):e101722. doi: 10.1136/bmjopen-2025-101722. ABSTRACT OBJECTIVES: To examine the association between workplace sexual harassment and post-traumatic stress disorder (PTSD) symptoms among nurses in southeast Iran. DESIGN: Cross-sectional study. SETTING: Four teaching hospitals affiliated with Kerman University of Medical Sciences, Iran. PARTICIPANTS: A total of 283 female nurses with at least 1 year […]
Perceptions of User-Generated Content as a Source of Health Messages in Smoking Cessation Mobile Interventions: Focus Group Study
JMIR Hum Factors. 2025 Dec 17;12:e76804. doi: 10.2196/76804. ABSTRACT BACKGROUND: Health messages are integral to smoking cessation interventions. Common approaches to health message development include expert-crafted messages and audience-generated messages, which produce messages that can be monotonic, didactic, and limited in number. We introduce an alternative approach to health message development that relies on user-generated […]
From Ethics to Application: Integrating Generative AI into Health Informatics Graduate Training
Generative artificial intelligence (AI) has emerged as one of the most transformative technologies shaping contemporary society, specifically in education and healthcare. Although AI has been discussed for decades, its widespread adoption in the 2020s has intensified both enthusiasm and concern regarding its ethical, educational, and professional implications. Generative AI is already influencing clinical practice, research, […]
