Children With Type 2 Diabetes Might Be Prone to Obesity - medtigo



Children With Type 2 Diabetes Might Be Prone to Obesity

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According to a study published in Jama Network, overweight teens and young adults are at a higher risk for a variety of health issues. Being overweight is associated with a variety of health problems, including hypertension, high cholesterol, poor glucose tolerance, and metabolic syndrome. Overweight children and adolescents frequently have other health issues, such as fatty liver disease, sleep apnea, asthma, dental difficulties, and poor posture.

The lifestyle choices of an individual have a significant influence on their metabolic risk. Youth who do not eat healthily, exercise often, or have active lives are more likely to develop insulin resistance. More than 75% of children with type 2 diabetes were also diagnosed with obesity at the time of diagnosis, according to a systematic review and meta-analysis of 53 studies involving over 9000 persons.

The findings of this study also shed insight on the relationships between sex and race in this group of overweight males. Obesity was found to be a significant risk factor for the development of T2D in children, while the study also demonstrated that not all T2D patients were overweight or obese. The study’s authors concluded that screening for obesity alone was unnecessary if other risk factors for type 2 diabetes were present.  

Obesity and type 2 diabetes are among the most expensive public health concerns. Identifying and evaluating trends in the prevalence of obesity in pediatric type 2 diabetes required researchers from McMaster University and other institutions around the world to conduct a systematic review and meta-analysis of literature dating back to the inception of the MEDLINE, Embase, CINAHL, Cochrane Library, and Web of Science databases.  

For observational studies on the prevalence of obesity in children with type 2 diabetes to be included in the meta-analysis, the sample size had to be at least 10. The combined prevalence of obesity in adults with type 2 diabetes was the key finding of this study. Secondary objectives of interest included relationships between BMI and glycemic control and dyslipidemia, as well as general prevalence rates broken down by race and sexual orientation. 

According to the findings, 75.27% (95% CI 70.47-79.78) of children and adolescents with type 2 diabetes were overweight or obese. Furthermore, 77.24% (95% CI, 70.55-83.34) of the 4688 patients were overweight or obese at the time they were diagnosed with diabetes, according to the study. Male participants in this research were more likely to be overweight than female participants.

Obesity prevalence was lowest among Asians (64.50 percent; 95% CI, 53.28 to 74.99 percent) and greatest among Whites (89.5 percent; CI, 71.50 to 99.74 percent). The researchers discovered significant inter-study heterogeneity in glycemic control and dyslipidemia.  

“Understanding the etiology of T2D in children without obesity is critical to developing appropriate management approaches for this population,” wrote the study’s authors. “Other traits, other than obesity, may increase the chance of having T2D in children,” and “further research is needed to understand the reasons of sex- and racial- and ethnicity-based connections of diabetes with obesity.”  


Obesity has a number of detrimental psychological and social consequences, including internalizing or externalizing disorders, body image issues, lower quality of life, low self-esteem, social isolation, and prejudice. Low mood is linked to weight growth, which can make your BMI look even higher.

Childhood obesity has serious physical and emotional repercussions, including increased morbidity and death in adulthood. A prospective study found that overweight teenage women are more likely to have social and economic challenges as adults.  

Obesity affects around 340 million children worldwide, making it a huge public health problem. Obesity has been connected to type 2 diabetes and other serious health problems. Understanding the link between body mass index and insulin resistance, glucose intolerance, type 2 diabetes, and associated comorbidities is critical for improving treatment outcomes via individualization.  

Despite the low to high risk of bias, different degrees of evidence, and substantial variability, up to one-quarter of children with T2D are not obese, and some have reference-range body mass readings. Although the findings suggest that BMI is not a good predictor of diabetes and that factors other than obesity play a role in the development of type 2 diabetes in children, they also make selecting the correct group for screening more challenging.

Obesity screening is commonly addressed in recommendations. More sophisticated prediabetes and diabetes prediction models are necessary to support a bigger screening approach, despite the fact that variables such as ethnicity and in utero diabetes predisposition are currently combined with BMI-based data to promote screening.

These models may combine parameters such as family history, in utero diabetes exposure, lifestyle factors, hormones, puberty, growth, sex, race/ethnicity, indications of insulin resistance, and the capacity to make insulin to better identify persons who may benefit from screening. 

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