Sergio Canavero, the Italian neurosurgeon, drew global attention last year by making the audacious claim that he was on the cusp of performing a head transplant, effectively attaching one individual’s head to another’s body. A recent resurgence of his assertion comes in the wake of his collaborators releasing video footage to multiple news outlets, notably featured on Sky News.
The footage depicts a dog seemingly recovering after experimental surgery that involved a complete severance and subsequent repair of the dog’s spinal cord. Canavero’s intricate technique is outlined in a paper published in the journal Surgical Neurology International, where he contends that this groundbreaking procedure could potentially pave the way for human head transplants, or more aptly described, full-body transplants, as soon as the forthcoming year.
However, a sense of skepticism pervades the medical community. Despite Canavero’s video evidence, doubts remain regarding the viability of his claims. New Scientist magazine scrutinized the research papers, enlisting the opinions of neuroscientist Jerry Silver from Case Western Reserve University. Silver’s verdict was cautious: “These papers do not support moving forward in humans.” It is worth noting that the dog featured in the video did not undergo a comprehensive full-body transplant; instead, its spinal cord was purportedly severed and subsequently repaired.
According to New York Times, While Canavero continues to maintain his stance, he is not the only surgeon harboring aspirations of executing what is colloquially dubbed a head transplant, or more appropriately, a full-body transplant. Dr. Xiaoping Ren, a Chinese orthopedic surgeon from Harbin Medical University, disclosed his intentions of assembling a team for a similar surgical procedure.
The notion of full-body transplants has enticed scientists, offering a potential solution to life-threatening conditions like spinal muscular atrophy, while also extending lifespans. However, the pursuit of such an endeavor is riddled with challenges of formidable proportions. Past endeavors in this realm were short-lived, as previous experiments involving similar procedures resulted in the survival of animals, typically mice, for a mere few days at most.
Critical Challenges to Overcome:
Prolonging Head Viability: Sustaining the vitality of the donated head until its integration into the recipient’s body poses a considerable hurdle. Cooling organs is a standard preservation technique, but the intricacies of preserving a head present a more complex task. The head encompasses various organs, including the brain, eyes, ears, nose, mouth, and skin, in addition to two separate gland systems. Immediate decapitation causes a swift drop in blood pressure, ultimately inducing a coma and ensuing death.
Immune System Compatibility: A recurrent challenge in transplantation is immune rejection. For the head transplant, which entails transplanting multiple organs, the risk of rejection is amplified. Immune-suppressing medications are typically administered to mitigate this response. The intricate nature of the head, housing multiple organs, elevates the risk of immune rejection.
Time-Sensitive Surgical Procedure: Historical precedent from experiments conducted by neurosurgeon Robert White in the 1970s underscores the necessity for expedited surgical procedures. According to White’s experiments and Canavero’s research, the entire procedure must be executed within an hour. This demands the simultaneous removal of both heads, followed by swift reattachment to the circulatory system of the donor’s body, all while both bodies are under cardiac arrest.
Seamless Spinal Cord Fusion: Facilitating effective communication and control between the preserved head and the new body hinges on seamless fusion of the spinal cord and brain. The prior experiment involving a monkey transplant demonstrated issues of paralysis and limited functionality. Canavero’s proposed solution, a “special biological glue” known as polyethylene glycol, aims to fuse the spinal cords. However, effective fusion remains a significant challenge.
Successful Animal Trials: Overcoming these challenges necessitates rigorous animal testing before human trials can commence. Ethical concerns surrounding animal cruelty complicate the approval process for such trials. Demonstrating the procedure’s efficacy and necessity is imperative for gaining ethical and regulatory approval. Sergio Canavero’s headline-grabbing claims of performing head transplants, supported by video footage, are met with skepticism among experts.
The concept of full-body transplants is captivating, offering potential solutions to life-threatening ailments. However, a host of insurmountable challenges must be addressed through meticulous research, rigorous animal trials, and ethical considerations before this groundbreaking procedure can transition from theoretical aspiration to practical reality. The path toward such a monumental achievement is fraught with complexities that demand scientific rigor, ethical contemplation, and unwavering dedication.