New Genetic Test Helps Target Semaglutide for Effective Weight Loss

A risk score biomarker that identifies a “hungry gut” phenotype might help determine whether semaglutide medications such as Wegovy are more likely to help a person lose weight, according to a study. 

For their findings, which haven’t been published yet in a peer-reviewed journal, researchers developed a machine-learning gene risk score to predict “hungry gut.” This occurs when someone eats a meal but feels hungry again after an hour or two due to their stomach emptying quickly. 

The researchers examined 84 people with obesity or other weight management issues. They collected saliva or blood samples for genetic analysis and obtained information on the participants’ eating habits. 

The participants took semaglutide medication for one year. The scientists recorded total body weight loss at 3, 6, 9, and 12 months. They then determined the probability of a positive semaglutide response based on the type of weight management issue. 

The researchers said the genetic test explains the differences and allows physicians to target the underlying cause of obesity. The researchers said the phenotype test could be used in healthcare settings to determine who would respond positively to semaglutide. 

The presentation indicates that the test predicts with 75% accuracy who will respond to semaglutide without using “trial and error” to determine whether a medication works. 

“Severe obesity is deadly since it creates a phase change. Thus, people’s bodies are 10 to 20 years older than their chronological age. Heart disease is the biggest killer. Semaglutide is a relatively new obesity medication. Researchers said knowing if the medication will work can help physicians and people better decide whether to try it. 

Semaglutide comes with side effects for instance people might experience GI symptoms, such as nausea, vomiting, diarrhoea, or constipation. Usually, side effects disappear as the body adjusts to the medication. Even so, starting with the lowest dose and increasing as necessary is important. 

Weight loss surgery is still the most effective for losing and maintaining weight loss.If they do not fit the criteria for surgery, doctors can consider the GLP-1 analogue medications, such as semaglutide.It is important to remember, no matter which treatment is used, the goal is to change habits, develop healthy eating patterns, and give lifelong changes.