Older Children More Prone To MIS-C: Study - medtigo


Older Children More Prone To MIS-C: Study

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According to a new study, older children and teens are the most vulnerable to severe episodes of an uncommon inflammatory condition that can emerge in children who have received COVID-19. 

As per US News, between March 1, 2020, and March 7, 2021, 232 children aged 18 and under were admitted to 15 hospitals in Canada, Costa Rica, and Iran with the probable multi-system inflammatory syndrome (MIS-C). 

Fever lasting at least three days; elevated C-reactive protein, which indicates inflammation; illness involving two or more systems with no obvious microbial cause of inflammation; and a positive COVID test or suspected contact with a positive case are all included in the World Health Organization’s definition of MIS-C. 

The majority of the patients in the research (89%) exhibited gastrointestinal symptoms like pain and skin issues like rashes and swelling (85 percent). Heart problems were widespread (59 percent), as were clotting issues (90 percent). 

73 (31.5%) of the 232 children were hospitalized in the intensive care unit, and 64 percent required extremely low blood pressure therapy. Children aged 6 to 12 years (44%) and 13 to 17 years (46%) had a higher probability of being admitted to the ICU than children aged five and under (18 percent). 

Children admitted to the hospital later in the pandemic (between November 2020 and March 2021) were more likely to be admitted to the intensive care unit (ICU) (50 of 112 or 45 percent) than those admitted earlier in the epidemic (between November 2020 and March 2021). (23 of 120, 19 percent). 

Patients with elevated blood markers for inflammation had a higher chance of severe MIS-C, according to the study. 

The research was published in the Canadian Medical Association Journal on April 11th. 

According to the researchers, diagnosing MIS-C can be difficult. 

Dr. Joan Robinson, a pediatrician at the University of Alberta in Edmonton, Canada, and co-authors, noted, “Multi-system inflammatory syndrome in children is a new diagnosis with varying diagnostic criteria that have not been validated.” 

According to a press release from the journal, “The majority of these children had no history of interaction with someone who had been infected with SARS-CoV-2. It can be difficult to determine exposure because sick contacts may be asymptomatic or have never been tested. “The study authors underlined that international agreement on MIS-C diagnostic criteria is required to better clinical care and research. 


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