Probiotics May Help Cure Dementia. Here's How - medtigo


Probiotics May Help Cure Dementia. Here’s How

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According to some research, probiotics and prebiotics may assist in slowing the progression of various neurodegenerative diseases. However, studies are scarce on their impact in patients with Alzheimer’s disease or mild cognitive impairment (MCI).

Jiangnan University scientists have collaborated to review the evidence so far. Their systematic review and meta-analysis findings were just published in the journal Foods. The authors conclude, “Our findings show that probiotic intervention at early stages of Alzheimer’s disease, such as MCI, could improve cognitive performance and delay disease development.”

ISAPP (International Scientific Association for Probiotics and Prebiotics) was established in 2002 as a non-profit organization. Its goal is to advance scientific research on probiotics, prebiotics, and synbiotics. According to the ISAPP, probiotics are living bacteria that “offer a health benefit to the host when administered in appropriate concentrations.”

Prebiotics, also known as substrates, is a type of nutrient that promotes the growth of gut bacteria. Synbiotics are a combination of probiotics and prebiotics. The researchers looked through several databases for studies published between 1984 and early 2021 that involved people with Alzheimer’s or MCI.

Only eight studies were chosen for the systematic review and seven for the meta-analysis after Zhu and colleagues sifted through 294 studies. The Mini-Mental State Examination was used to assess cognitive function, which was the primary endpoint of all investigations (MMSE). Secondary outcomes included nutritional status, inflammatory biomarkers, metabolic profiles, and oxidative stress.

According to the study’s authors, probiotic probiotics increased cognitive performance in persons with MCI. Alzheimer’s disease patients, on the other hand, had less impressive results. In general, the authors reach the following conclusion:

“When compared to placebo or control therapy, probiotic supplementation considerably improved cognitive performance in persons with MCI, but it only offered a small cognitive improvement in those with Alzheimer’s disease.”

How much cognitive improvement was gained depended on the number of probiotic strains given, their dosage, and the length of treatment.

Probiotic treatment altered the structure and content of the microbiota in the feces of Alzheimer’s patients.

According to the co-authors, there is a decline in fecal microbial diversity in Alzheimer’s patients. According to only one study in the review, probiotic therapy affected the structure and makeup of the fecal microbiota in Alzheimer’s patients.

According to the experts, the meta-analysis conducted by Zhu and colleagues contained severe problems. Some of the studies had modest sample sizes, to begin with.

Furthermore, the research did not consider how other dietary supplements or lifestyles may have altered gut flora and metabolic profiles. In the study included, different rating measures for cognitive impairment were also used to test cognitive function. The widely used NINCDS-ADRDA dementia criteria were used in only four studies included in the evaluation.

There were no harmful effects of probiotic supplementation in four of the studies. While probiotics have been generally safe, older people are more prone to develop gastrointestinal severe, cutaneous, and systemic side effects.

According to Zhu and his colleagues, errors in study design and commercial sponsorship may have skewed specific results.

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