A significant health and financial concern is obesity. It frequently coexists with a variety of illnesses, including neurodegenerative disorders. Obesity and multiple sclerosis, or MS, have been linked in observational studies in recent years, according to mounting data. MS is a disabling, chronic, demyelinating, and neurodegenerative condition affecting the central nervous system and impairing function.
According to several observational studies, children with a greater body mass index (BMI) had a higher risk of having MS later in life. There is a 101% increased chance of having MS in obese children compared to normal-weight kids.
Additionally, before Mendelian randomization (MR), Research suggested that BMI may have a causal relationship with MS.10–13 These epidemiological studies give insights into genetic risk factors similar to obesity and MS. The shared genetic architecture between obesity and MS is mainly unclear, and more recent data are required to assess their causality.
Determining the biology and causality underlying this connection is crucial for understanding the etiology of MS and may offer therapeutic insights. Many different mechanisms have been suggested. According to studies, fat makes multiple sclerosis impairment and central inflammation worse. In obese people, changes in hormones and gut microbiota may also contribute to the development of MS.
According to Research published in The Lancet in several observational studies, children with a higher body mass index (BMI) have a higher chance of having multiple sclerosis (MS). However, nothing is known about how hereditary variables contribute to their comorbidity.
This study established a substantial genetic link and discovered common risk SNPs between BMI and MS by utilizing data from genome-wide association studies. We also discovered a possible functional gene shared by MS and obesity. These findings might provide light on the genetic architecture that MS and obesity share.
Researchers discovered a significant genetic association between BMI and MS and shared risk SNPs (Single Nucleotide Polymorphisms). Researchers also discovered a probable functional gene, GGNBP2 (Gametogenetin Binding Protein 2), linked to obesity and multiple sclerosis. These results may shed light on the genetic basis of MS and obesity, help us comprehend their pathophysiology, and pave the way for the creation of new treatments.
According to a study, it’s critical to identify and treat neurodegenerative diseases like MS in overweight and obese patients early on. It is intriguing to develop approaches targeting both diseases based on their shared genetic architecture, and new treatments for the two disorders could be investigated. This discovery may also lead to fresh insights into the etiology of the two diseases and encourage more investigation into their comorbidity.