Atopic dermatitis (AD) is basically a skin disease and also known as eczema. It usually shows symptoms like redness and itchiness. There are many medications available to treat this disease. But their effectiveness and safety were unknown. So, researchers from the University of California San Diego conducted a study to understand the effectiveness of ruxolitinib cream. Then they have found that teenagers can use ruxolitinib cream for a long term and it is safe and effectively helps them.Â
This research was published in the American Journal of Clinical Dermatology. In this study, researchers involved 245 teenagers with AD. These teenagers were aged between 12 to 17 and they had AD for at least two years. These teenagers were asked to use 1.5% ruxolitinib cream. Researchers tracked them and collected the data. Then they compared it with the data of teenagers who used vehicles. Â
When researchers observed the collected data and studied it, they found that 1.5% ruxolitinib cream worked very effectively as compared to vehicle at 8th week. Teenagers who used 1.5% ruxolitinib cream had very clear or almost clean skin as compared to those who used vehicles. They also found that the severity of AD was reduced in teenagers who used ruxolitinib as it was 52.1%. On the other hand, it was 17.4% for those who used the vehicle. Â
Researchers also found that the 1.5% ruxolitinib cream was effective after its one year of use. It still showed its effectiveness and treated the patients with AD. They also checked the levels of ruxilitinib in the blood of these teenagers at 12 weeks and 52 weeks. Then they found that it was low and steady. It proved that 1.5% ruxolitinib cream is very safe and effective. But a few teenagers (1.8%) had side effects as they had skin reactions where they applied this cream. Researchers also noticed that these teenagers did not have any serious side effects. Â
This study was paid for by the company that makes 1.5% ruxolitinib cream known as Incyte. Researchers of this study found that 1.5% ruxolitinib cream is effective and safe for treating teenagers with atopic dermatitis. So, healthcare professionals should prescribe this cream. Â
Reference Link:Â
Lawrence F. Eichenfield et al, Efficacy, Safety, and Long-Term Disease Control of Ruxolitinib Cream Among Adolescents with Atopic Dermatitis: Pooled Results from Two Randomized Phase 3 Studies, American Journal of Clinical Dermatology (2024). Â
