Orally administer injectable
Continuous Intravenous infusion is advised for acute ingestion (preferably within 8-10 hours of ingestion but may be administered if more than 10 hours)
Intermittent Intravenous infusion may be recommended for chronic ingestion or late presenting (more than 10 hours after the ingestion)
Orally administer injectable 140 mg/kg orally as a loading dose
Maintenance dose: 4 hours after the loading dosage, administer 70 mg/kg orally every 4hours for a total of 17 doses; repeat dosage if emesis occurs within the 1 hour of administration
Intravenous continuous infusion Acute intake (within 8-10 hours after ingestion) 3 doses should be administered
Loading dose: 150 mg/kg intravenous, followed by 200 mL of D5W infusion over 1 hour
Dosage 2: 50 mg/kg Intravenous in 500 mL D5W over 4 hours
Dosage 3: 100 mg/kg Intravenous in 1000 mL D5W over 16 hours
More than 100 kg: There have been no studies; A loading dosage of 15,000 mg injected Intravenous over 1 hour, followed by a first maintenance dose of 5,000 mg intravenous over 4 hours and then a second maintenance dosage of 10,000 mg over 16 hours, according to limited data
Intermittent Intravenous administration (off-label)
The Total therapy time: 48 hours
chronic ingestion or Late presenting (more than 10 hours after ingestion) in patients with more than 40 kg
140 mg/kg Intravenous given over 1 hr (diluted in 500 mL of D5W) as loading dose, following
Maintenance dose: 70 mg/kg intravenous every 4 hours for at least 12 doses (Each dosage should be diluted in 250 mL of D5W and infused for at least 1 hour)

Injectable:
The maximum dose is 300 mg/kg, given in 3 different doses over the course of 21 hours.
140 mg/kg PO as a loading dose
4 hours after the loading dose, begin 70 mg/kg PO q4hr for a total of 17 doses; repeat dose if emesis occurs within 1 hour of administration.
Continuous IV infusion
Acute consumption (within 8-10 hr after ingestion)
Three doses should be administered
Loading dose: 150 mg/kg IV, followed by 200 mL of D5W infusion over 1 hour.
Dose 2: 50 mg/kg IV over 4 hours in 500 mL D5W, THEN
Dose 3:
100 mg/kg IV over 16 hours in 1000 mL D5W
>100 kg: No specific studies have been conducted; limited data suggest a loading dose of 15,000 mg IV over 1 hour, followed by a first maintenance dose of 5,000 mg IV over 4 hours and a second maintenance dose of 10,000 mg IV over 16 hours.
Intermittent intravenous administration (off-label)
Total treatment time is 48 hours.
Late or chronic ingestion (>10 hours after ingestion)
patients weighing more than 40 kg
140 mg/kg IV infused over 1 hour (diluted in 500 mL D5W), THEN
Maintenance dose: 70 mg/kg IV every four hours for at least 12 doses (dilute each dose in 250 mL of D5W and infuse over minimum 1 hr)

Orally administer injectable Continuous intravenous infusion is advised for acute ingestion (preferably within 8-10 hours of ingestion but may be administered if more than 10 hours)
Intermittent intravenous infusion may be recommended for chronic ingestion or late presenting (more than 10 hours after the ingestion)
Orally administration 140 mg/kg orally as a loading dose
Maintenance dose: 4 hours after the loading dosage, administer 70 mg/kg orally every 4hours for a total of 17 doses; repeat dosage if emesis occurs within the 1 hour of administration
below 20 kg Intravenous continuous infusion (Acetadote)
150 mg/kg intravenous in 3 mL diluent/kg of body weight given over 1 hour as Loading dose
Dosage 2: 50 mg/kg intravenous in 7 mL diluent/kg of body weight administered over 4-hours
Dosage 3: 100 mg/kg in 14 mL diluent/kg of body weight administered over 16-hours
Above 20 kg to below 40 kg Intravenous continuous infusion (Acetadote)
150 mg/kg Intravenous in 100 mL of diluent given over 1 hour as loading Dose
Dosage 2: 50 mg/kg Intravenous in 250 mL of diluent given over 4 hours
Dosage 3: 100 mg/kg Intravenous in 500 mL of diluent given over 16 hours
Weight more than 40 kg for Intravenous continuous infusion (Acetadote)
As adults
150 mg/kg Intravenous; combine in 200 mL of the D5W and then infuse for 1 hour as loading dose
Dosage 2: 50 mg/kg Intravenous over 4 hours in 500 mL D5W, following
Dosage 3: 100 mg/kg Intravenous in 1000 mL D5W administered over 16 hours
Intermittent infusion (Off-label)
The Total therapy time: 48 hours
chronic ingestion or Late presenting (more than 10 hours after ingestion) in patients with more than 40 kg
A Loading dose: 140 mg/kg Intravenous given over 1 hr (diluted in 500 mL of D5W), following
Maintenance dose: 70 mg/kg intravenous every 4 hours for at least 12 doses (Each dosage should be diluted in 250 mL of D5W and infused for at least 1 hour)