Loading dose:
Patients who have not previously taken aminophylline or theophylline: during the last 24 hrs: administer 5.7 mg/kg intravenous infusion
Patients who have taken aminophylline or theophylline during the last 24 hrs: Before administering a loading dose, determine the serum theophylline concentration Maintenance dose:
Adults below 60 yrs: 0.5 mg/kg/hour intravenous continuous infusion; should not exceed more than 1,125 mg/day
Note: The doses are designed to attain 10 mcg/mL serum theophylline levels
Dose Adjustments
Dosing modifications
Renal impairment:
Dose adjustment is not required Hepatic impairment:
0.25 mg/kg/hour of initial dose, should not exceed a maximum of 500 mg/day
(Off-label):
According to NIH asthma guidelines
Age: <5 years: 2 inhalations every 20min for 1 hour
Age: 5-12 years: 4-8 actuations every 20 min for about 3 hours as needed
Age: ≥12 years: 8 actuation every 20 min for about 3 hours as needed
Age: <5 years: 0.25 mg every 20min for 1 hour
Age: 5-12 years: 250-500 mcg every 20 min for 1 hour 3 doses, then as needed
Age: ≥12 years: 500 mcg every 20 min for 1 hour 3 doses, then as needed
Loading dose:
Patients who have not previously taken aminophylline or theophylline: during the last 24 hrs: administer 5.7 mg/kg intravenous infusion
Patients who have taken aminophylline or theophylline during the last 24 hrs: Before administering a loading dose, determine the serum theophylline concentration Maintenance dose:
Infants (4 to 6 weeks): 1.9 mg/kg/dosage intravenous every 2 times a day
Children 1 to 8 years: 1 mg/kg/hour continuous intravenous infusion
Children 9 to 11 years: 0.9 mg/kg/hour continuous intravenous infusion
Adolescents 12 to 16 years: 0.9 mg/kg/hour continuous intravenous infusion
Adolescents above 16 years: 0.5 mg/kg/hour continuous intravenous infusion; should not exceed more than 1,125 mg/day
Note: The doses are designed to attain 10 mcg/mL serum theophylline levels
Dose Adjustments
Dosing modifications
Renal impairment:
Dose adjustment is not required. Hepatic impairment:
0.25 mg/kg/hour of initial dose, should not exceed a maximum of 500 mg/day
Loading dose:
Patients who have not previously taken aminophylline or theophylline: during the last 24 hrs: administer 5.7 mg/kg intravenous infusion
Patients who have taken aminophylline or theophylline during the last 24 hrs: Before administering a loading dose, determine the serum theophylline concentration Maintenance dose:
Adults below 60 yrs: 0.5 mg/kg/hour intravenous continuous infusion; should not exceed more than 1,125 mg/day
Note: The doses are designed to attain 10 mcg/mL serum theophylline levels
Dose Adjustments
Dosing modifications
Renal impairment:
Dose adjustment is not required Hepatic impairment:
0.25 mg/kg/hour of initial dose, should not exceed a maximum of 500 mg/day
(Off-label):
According to NIH asthma guidelines
Age: <5 years: 2 inhalations every 20min for 1 hour
Age: 5-12 years: 4-8 actuations every 20 min for about 3 hours as needed
Age: ≥12 years: 8 actuation every 20 min for about 3 hours as needed
Age: <5 years: 0.25 mg every 20min for 1 hour
Age: 5-12 years: 250-500 mcg every 20 min for 1 hour 3 doses, then as needed
Age: ≥12 years: 500 mcg every 20 min for 1 hour 3 doses, then as needed
Loading dose:
Patients who have not previously taken aminophylline or theophylline: during the last 24 hrs: administer 5.7 mg/kg intravenous infusion
Patients who have taken aminophylline or theophylline during the last 24 hrs: Before administering a loading dose, determine the serum theophylline concentration Maintenance dose:
Infants (4 to 6 weeks): 1.9 mg/kg/dosage intravenous every 2 times a day
Children 1 to 8 years: 1 mg/kg/hour continuous intravenous infusion
Children 9 to 11 years: 0.9 mg/kg/hour continuous intravenous infusion
Adolescents 12 to 16 years: 0.9 mg/kg/hour continuous intravenous infusion
Adolescents above 16 years: 0.5 mg/kg/hour continuous intravenous infusion; should not exceed more than 1,125 mg/day
Note: The doses are designed to attain 10 mcg/mL serum theophylline levels
Dose Adjustments
Dosing modifications
Renal impairment:
Dose adjustment is not required. Hepatic impairment:
0.25 mg/kg/hour of initial dose, should not exceed a maximum of 500 mg/day
Adults above 60yrs: 0.38 mg/kg/hour continuous intravenous infusion; should not exceed a maximum of 500 mg/day
medtigo
Acute Asthma Exacerbation
Updated :
August 28, 2022
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