Prime Editing Unlocks a Universal Strategy for Restoring Lost Proteins
November 22, 2025
Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
Indicated of Adequate Intake
Male: 1.9 mg -2.3 mg every day
Female: 1.6 mg -1.8 mg every day
Pregnancy: 2 mg every day
Lactation: 2.6 mg every day
For Deficiency Prevention
Parenteral solution (TPN):
150 mcg -800 mcg every day intravenously
Osteoporosis as Off-label
5 mg orally every day
Indicated for Adequate Intake
Age <6 months: 0.3 mg -0.6 mg every day
Age 6-12 months: 0.6 mg -1.0 mg every day
Age 1-3 years: 1.0 mg -1.5 mg every day
Age 3-8 years: 1.5 mg -2.0 mg every day
Age 8-13 years: 1.9 mg every day (Males); 1.6 mg every day (Females)
Age 13-18 years: 2.2 mg every day (Males); 1.6 mg every day (Females)
For Deficiency Prevention
Parenteral solution (TPN):
2-10 mcg/kg every day intravenously
Dose Consideration
Potential toxic dose below the 6 years: 8 mg/kg
1 ppm = 1 mg fluoride ion
1 mg fluoride ion is contained in 2.2 mg sodium fluoride:
Dosing is determined by the fluoride concentration of the local water supply
Water below the 0.3 ppm fluoride ion
From Birth to 6 months: None
6 months to 3 years: 0.25 mg orally every day
3 to 6 years: 0.5 mg orally every day
6 to 16 years: 1 mg orally every day
Water 0.3 to 0.6 ppm fluoride ion
From Birth to 6 months: None
6 months to 3 years: None
3 to 6 years: 0.25 mg orally every day
6 to 16 years: 0.5 mg orally every day
Water above the 0.6 ppm fluoride ion
All ages: No further supplements are necessary
Future Trends
References

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