Angioma serpiginosum is an uncommon, benign skin illness characterized by violaceous to red punctate lesions on an erythematous base. Classical pinpoint puncta are generated by ectasia or hyperplasia of preexisting superficial cutaneous capillaries.
Angioma serpiginosum was first reported by Hutchinson in 1889 as a rare kind of serpiginous angioma and was later dubbed as an “infective” nevoid illness. In 1893, Radcliffe-Crocker coined the term “angioma serpiginosum.”
Females are 9 times more likely to be affected with angioma serpiginosum than males. This skin infection is extremely rare, affecting only 1 out of a million individuals.
80% of cases present early, generally before the age of 20, and most cases are reported in early childhood. Infants might also be affected since birth.
Angioma serpiginosum originates from the rapid multiplication of endothelial cells and the development of new capillaries, not from the dilatation of existing capillaries alone.
Due to the absence of progesterone and estrogen receptors on the connected blood arteries, researchers have disproven the involvement of hormones in the pathophysiology of vascular endothelial proliferation.
A second hypothesized etiology is an irregular vascular response to cold temperatures which results in the creation and accumulation of freshly formed capillaries, which therein leads to the production of big ectatic vessels in the papillary dermis.
The majority of angioma serpiginosum cases are sporadic. Yet, the dominance of both x-linked inheritance, and autosomal dominant genes have been observed. Reports of isolated cases imply that an Xp11.23 deletion involving the PORCN gene is one of the potential causes of this condition.
Nevertheless, this was later refuted by other employees. Later investigations have also refuted the notion that angioma serpiginosum constitutes a moderate type of focal dermal hypoplasia, which is related with PORCN gene alterations.
Angioma serpiginosum is rarely associated with major complications, however, there have been reports of CNS, and ocular involvement. Rare manifestations include familial occurrences, a delayed onset, and significant skin involvement.
Angioma serpiginosum is also rarely linked with conditions such as esophageal papillomatosis, cherry angioma, retinal vein occlusion, and vulval angiokeratomas.
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https://www.ncbi.nlm.nih.gov/books/NBK459213/
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Angioma serpiginosum is an uncommon, benign skin illness characterized by violaceous to red punctate lesions on an erythematous base. Classical pinpoint puncta are generated by ectasia or hyperplasia of preexisting superficial cutaneous capillaries.
Angioma serpiginosum was first reported by Hutchinson in 1889 as a rare kind of serpiginous angioma and was later dubbed as an “infective” nevoid illness. In 1893, Radcliffe-Crocker coined the term “angioma serpiginosum.”
Females are 9 times more likely to be affected with angioma serpiginosum than males. This skin infection is extremely rare, affecting only 1 out of a million individuals.
80% of cases present early, generally before the age of 20, and most cases are reported in early childhood. Infants might also be affected since birth.
Angioma serpiginosum originates from the rapid multiplication of endothelial cells and the development of new capillaries, not from the dilatation of existing capillaries alone.
Due to the absence of progesterone and estrogen receptors on the connected blood arteries, researchers have disproven the involvement of hormones in the pathophysiology of vascular endothelial proliferation.
A second hypothesized etiology is an irregular vascular response to cold temperatures which results in the creation and accumulation of freshly formed capillaries, which therein leads to the production of big ectatic vessels in the papillary dermis.
The majority of angioma serpiginosum cases are sporadic. Yet, the dominance of both x-linked inheritance, and autosomal dominant genes have been observed. Reports of isolated cases imply that an Xp11.23 deletion involving the PORCN gene is one of the potential causes of this condition.
Nevertheless, this was later refuted by other employees. Later investigations have also refuted the notion that angioma serpiginosum constitutes a moderate type of focal dermal hypoplasia, which is related with PORCN gene alterations.
Angioma serpiginosum is rarely associated with major complications, however, there have been reports of CNS, and ocular involvement. Rare manifestations include familial occurrences, a delayed onset, and significant skin involvement.
Angioma serpiginosum is also rarely linked with conditions such as esophageal papillomatosis, cherry angioma, retinal vein occlusion, and vulval angiokeratomas.
https://www.ncbi.nlm.nih.gov/books/NBK459213/
medtigo
Angioma Serpiginosum
Updated :
August 8, 2022
Angioma serpiginosum is an uncommon, benign skin illness characterized by violaceous to red punctate lesions on an erythematous base. Classical pinpoint puncta are generated by ectasia or hyperplasia of preexisting superficial cutaneous capillaries.
Angioma serpiginosum was first reported by Hutchinson in 1889 as a rare kind of serpiginous angioma and was later dubbed as an “infective” nevoid illness. In 1893, Radcliffe-Crocker coined the term “angioma serpiginosum.”
Females are 9 times more likely to be affected with angioma serpiginosum than males. This skin infection is extremely rare, affecting only 1 out of a million individuals.
80% of cases present early, generally before the age of 20, and most cases are reported in early childhood. Infants might also be affected since birth.
Angioma serpiginosum originates from the rapid multiplication of endothelial cells and the development of new capillaries, not from the dilatation of existing capillaries alone.
Due to the absence of progesterone and estrogen receptors on the connected blood arteries, researchers have disproven the involvement of hormones in the pathophysiology of vascular endothelial proliferation.
A second hypothesized etiology is an irregular vascular response to cold temperatures which results in the creation and accumulation of freshly formed capillaries, which therein leads to the production of big ectatic vessels in the papillary dermis.
The majority of angioma serpiginosum cases are sporadic. Yet, the dominance of both x-linked inheritance, and autosomal dominant genes have been observed. Reports of isolated cases imply that an Xp11.23 deletion involving the PORCN gene is one of the potential causes of this condition.
Nevertheless, this was later refuted by other employees. Later investigations have also refuted the notion that angioma serpiginosum constitutes a moderate type of focal dermal hypoplasia, which is related with PORCN gene alterations.
Angioma serpiginosum is rarely associated with major complications, however, there have been reports of CNS, and ocular involvement. Rare manifestations include familial occurrences, a delayed onset, and significant skin involvement.
Angioma serpiginosum is also rarely linked with conditions such as esophageal papillomatosis, cherry angioma, retinal vein occlusion, and vulval angiokeratomas.
https://www.ncbi.nlm.nih.gov/books/NBK459213/
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