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Anticoagulants

Updated : September 2, 2022



Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

dalteparin 


Indicated for Anti-coagulation therapy (Off label):

200

IU/kg

Solutions

subcutaneously

every 12 hours


or 100 units/kg subcutaneous



tinzaparin 

Indicated for Anticoagulant in the extracorporeal circuit during hemodialysis:


Intravenous
Dialysis sessions less than 4 hours:
Initial bolus (via the vascular side of the circuit or IV): 4,500 anti-Xa units at the start of dialysis; usually reaches plasma concentrations ranging from 0.5 to 1 anti-Xa unit/mL; may administer larger dose for dialysis periods lasting longer than 4 hours. Based on prior results, modify dosage in 500 anti-Xa unit intervals for future dialysis treatments.

Dialysis sessions of more than 4 hours:
Initial IV bolus: 2,250 anti-Xa units. (do not add to dialysis circuit). Dialysis intervals over 4 hours may require a lower second IV dose. In successive dialysis sessions, adjust the dose to reach plasma amounts of 0.2 to 0.4 anti-Xa units/mL.

Mechanical prosthetic heart valve to bridge anticoagulation
Administer 175 anti-Xa units/kg daily once
The dosage may be modified perioperatively based on anti-factor Xa monitoring for high-risk operations and treatments.



heparin 

Intermittent intravenous injection
8000-10,000 units intravenous initially, following 50-70 units/kg (5000-10,000 units) every 4-6 hours
Continuous intravenous infusion
5000 units intravenous injection, then by continuous intravenous infusion of 20,000-40,000 units/24 hours
Dosing considerations
There are several concentrations available; extreme caution is necessary to prevent a medication error
When heparin is administered with warfarin sodium or dicumarol, a delay of 24 hours after the last subcutaneous dose or 5 hours after the last intravenous dose should be given before blood is collected if a prothrombin time is achieved.



 
 

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Anticoagulants

Updated : September 2, 2022


dalteparin 


Indicated for Anti-coagulation therapy (Off label):

200

IU/kg

Solutions

subcutaneously

every 12 hours


or 100 units/kg subcutaneous



tinzaparin 

Indicated for Anticoagulant in the extracorporeal circuit during hemodialysis:


Intravenous
Dialysis sessions less than 4 hours:
Initial bolus (via the vascular side of the circuit or IV): 4,500 anti-Xa units at the start of dialysis; usually reaches plasma concentrations ranging from 0.5 to 1 anti-Xa unit/mL; may administer larger dose for dialysis periods lasting longer than 4 hours. Based on prior results, modify dosage in 500 anti-Xa unit intervals for future dialysis treatments.

Dialysis sessions of more than 4 hours:
Initial IV bolus: 2,250 anti-Xa units. (do not add to dialysis circuit). Dialysis intervals over 4 hours may require a lower second IV dose. In successive dialysis sessions, adjust the dose to reach plasma amounts of 0.2 to 0.4 anti-Xa units/mL.

Mechanical prosthetic heart valve to bridge anticoagulation
Administer 175 anti-Xa units/kg daily once
The dosage may be modified perioperatively based on anti-factor Xa monitoring for high-risk operations and treatments.



heparin 

Intermittent intravenous injection
8000-10,000 units intravenous initially, following 50-70 units/kg (5000-10,000 units) every 4-6 hours
Continuous intravenous infusion
5000 units intravenous injection, then by continuous intravenous infusion of 20,000-40,000 units/24 hours
Dosing considerations
There are several concentrations available; extreme caution is necessary to prevent a medication error
When heparin is administered with warfarin sodium or dicumarol, a delay of 24 hours after the last subcutaneous dose or 5 hours after the last intravenous dose should be given before blood is collected if a prothrombin time is achieved.



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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.

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CONTACT INFORMATION

ADDRESS

MASSACHUSETTS – USA

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Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra

 

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