Antidysrhythmic toxicity is known as the potential adverse effects of medications used to treat abnormal heart rhythms. 

Antiarrhythmic drugs used to regulate the heart’s electrical activity and to restore normal heart rhythm. 

Antidysrhythmic toxicity is a rare adverse event when compared with other drug-related side effects. 

It occurs in both sexes equally and the prodysrhythmic effects are common in patients with underlying heart failure. 

Antidysrhythmic drugs targets on specific ion channels to generate action potentials in the heart. 

Blockage of excessive sodium channels causes delay in the QRS complex of an ECG and increase the chances of ventricular arrhythmias. 

Prolonged use of antidysrhythmic can increase risk of toxicity, especially in cases where the doses are not adjusted as per renal function and electrolyte levels. 

Patients with impaired cardiac function may experience more adverse effects and a poor prognosis. 

The outcome of a toxicity is influenced by the specific antidysrhythmic agent. 

Antidysrhythmic toxicity affect individuals of all age groups, from infants to elderly individuals.  

• Cardiovascular Examination 
• Respiratory Examination 
• Gastrointestinal Examination 

Acute presentations can result from overdose, rapid intravenous administration, and drug-drug interactions causing sudden toxicity. 

Chronic overdosing, cumulative drug accumulation, or delayed adverse reaction onset can lead to subacute presentations. 

In immediate assessment and stabilization support includes assessment of the patient’s airway, breathing, and circulation (ABCs). 

Necessary care should be given under observation of a physician, so it will stabilize the patient’s health condition and it helps to maintain the functions of vital organs. 

Regular monitoring of blood pressure, heart rate, and oxygen level of a patient should be recorded by nursing staff daily in specific intervals. 

Emergency Medicine

Family of patient as well as physician should ensure a safe environment for the patient and give attention to any type of falls and accidents.  

Patients surrounding should be ready with appropriate monitoring equipment to give continuous assessment. 

Schedule follow-up visits to monitor the progress of patients, recovery, and ensure resolution of symptoms. 

Emergency Medicine

Activated charcoal: It is a potent substance that directly binds with toxins in the gastrointestinal tract which helps to prevents the absorption into the bloodstream. 

Emergency Medicine

Calcium chloride is a calcium ion source that has positive inotropic effects on the myocardium and helps to increase cardiac contraction. 

It is administered intravenously as a bolus injection under the guidance of physician and nursing staff. 

Magnesium sulfate is a physiological calcium antagonist which influences calcium-dependent processes in cardiac muscle cells. 

Emergency Medicine

Diazepam indirectly alleviate stress and sympathetic activation’s hemodynamic effects which potentially stabilizes cardiac rhythm and improves overall clinical outcomes. 

Emergency Medicine

Severe antidysrhythmic toxicity can lead to mental changes, respiratory depression in such cases emergency physician should choose intervention with airway management procedures. 

The cardiovascular support procedures is also indicated in case of unstable arrhythmias such as ventricular tachycardia. 

Give proper supply of intravenous access to administer fluids, medications, and other interventions as needed and as advised by physician in emergency cases. 

Emergency Medicine

In the initial assessment phase, activities like clinical assessment, including vital signs, cardiac rhythm monitoring, neurological status, and evaluation for signs of hemodynamic instability should be performed by the physician.  

Surgical intervention is needed as per the patient’s condition and the situation of the antidysrhythmic toxicity condition.   

In supportive phase, patients should receive all the required attention in the form of postoperative care, monitoring, and rehabilitation. 

Provide proper education antidysrhythmic toxicity about and its related causes, how it spreads, and how to stop it with management strategies.