Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Background
In this medical condition the bacteria are present in the bloodstream. This infection generally seen in various body parts like urinary tract and skin.Â
Bacteremia is classified as transient and persistent category.Â
Transient bacteremia is common. It seen during dental procedures and is usually asymptomatic and self-limited. But persistent bacteremia occurs when bacteria present in the bloodstream for a longer time.Â
Epidemiology
The incidence is noted higher in elderly patients and in hospitalized patients for e.g., intensive care units.Â
In developed countries gram-positive bacteria are common causes of bacteremia. Gram-negative bacteria are more common in developing countries. Â
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Anatomy
Pathophysiology
Bacteremia can be caused by various factors. It includes infections in different regions of the body and invasive medical procedures.Â
Once bacteria enter the bloodstream. They can interact with immune cells which triggers an inflammatory reaction. This leads to the release of cytokines can cause fever and chills.Â
This disorder need to be treated otherwise it may cause the sepsis. It is a potentially fatal illness.Â
Â
Etiology
A gram-positive bacterium is a common cause of bacteremia. It is observed in hospitalized patients and those with weakened immune systems.Â
This disorder is responsible to cause pneumonia, meningitis, and UTI.Â
Genetics
Prognostic Factors
Old age people have higher chances to die from bacteremia. In case of underlying medical disorders the patients are at a higher risk of complications.Â
The severity of sickness while examination can have an impact on the prognosis of patients.Â
Â
Clinical History
It depends on the patient’s age. In neonates and young infants, it presents with nonspecific symptoms such as fever and poor feeding. Â
Physical Examination
FeverÂ
TachycardiaÂ
Joint pain Â
Respiratory distressÂ
Hypotension Â
Skin rashÂ
Abdominal painÂ
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Acute onset of symptoms observes a more severe and rapidly progressing infection. In slower onset of symptoms may show a chronic or subacute infection.Â
Differential Diagnoses
Bacterial infections Â
Parasitic infectionsÂ
Fungal infections Â
Viral infectionsÂ
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
The diagnosis of bacterium illness depends on blood cultures. The empirical broad-spectrum antibiotics are used as first-line therapy. Â
In definitive therapy phase it minimizes the use of broad-spectrum antibiotics and reduce the risk of antibiotic resistance. Â
Antibiotic resistance and associated consequences can be reduced by using shorter doses of antibiotics when affordable. Â
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-a-non-pharmacological-approach-for-treating-bacteremia
Source control helps prevent ongoing introduction of bacteria into the bloodstream. Â
Non-pharmacological supportive measures, such as fluid resuscitation and maintenance are important for stabilizing patients with bacteremia. Â
To maintain optimal nutrition for patients it supports the immune system and overall recovery. Â
Fever is a common symptom of bacteremia. For that the cooling blankets and tepid sponge baths are used to manage fever and improve patient comfort. Â
Role of broad-spectrum antibiotics in the treatment of bacteremia
Cephalosporins belongs to the class of antibiotics which are used in the treatment of bacteremia. It will block the production of bacterial cell walls. Â
use-of-intervention-with-a-procedure-in-treating-bacteremia
Blood cultures are a critical diagnostic procedure in the evaluation of bacteremia. In some cases, endoscopy may be used to identify and treat infections in the gastrointestinal or respiratory tracts.Â
In cases of soft tissue infections, surgical debridement may be performed to remove infected tissue and promote healing. Â
use-of-phases-in-managing-bacteremia
In the initial phase the physician should obtain blood cultures before starting antibiotics to identify the causative organism. Evaluate the patient’s clinical status, signs, and symptoms of infection. Then adjust therapy based on culture results and susceptibility testing. Â
Identify and address the source of infection for e.g., abscess, infected catheter, dental infection. Schedule follow-up appointments to monitor for relapse or recurrence.Â
Medication
1 g IM or IV given every 12hrs for mild conditions
1-2 g IM or IV every 8hrs moderate to severe infections
2 g IV every 6-8hrs high dosing for infections
2 g IV every 4hrs for life-threatening infections
12 g is the maximum dose required per day
initial dose:
200
mg
Intravenous (IV)
followed by 100 mg IV for every 12hrs maximum dose: 400 mg IV per day
1-2 g IV or IM was given once a day or in equally divided doses 2x a day
maximum duration of therapy is 4-14 days
prolonged treatment recommends for complicated infections
At least treatment given ten days for diseases due to streptococcus pyogenes
indicated for Staphylococcus aureus bacteremia:
6
mg/kg
Lyophilized powder for reconstitution, i
Intravenous (IV)
every 24 hours
2 - 6
weeks
Off-label:
7.5
mg/kg
Intravenous (IV)
3 times a day
It is an antibacterial used to fight bacteria in our body that causes infections
The usual dose for the treatment of bacteremia is 1 to 4 g via Intravenous or Intramuscular administration twice or thrice a day for up to 14 days. The duration of the treatment depends on the severity and the nature of the infections
If the infection is severe, the dose can be increased up to 12 g per day
Dose Adjustments
Renal Dose Adjustment
In case of renal insufficiency, the usual dose of ceftizoxime depends on the CrCl. If the CrCl is below 5 mL/min, then 0.25-0.5 g a day or 0.5-1 g via IV or IM in 2 days after undergoing dialysis. Loading dose is standard in renal insufficiency, which is 0.5-1 g. 0.25 -1g twice a day if CrCl falls between 5 and 49 mL/min and 0.5 – 1.5 g thrice a day if CrCl is between 50 and 79 mL/min
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
Age:> 1year
20-40 mg per kg IV or IM given every 12hrs
Surgical Prophylaxis:
Age:> 1year
40 mg per kg IV once 30-60 minutes before surgery
but in some cases, if ruptured viscus was seen, gentamicin 2 mg per kg may be added
Indicated for Staphylococcus aureus bacteremia:
<1 year: Safety and efficacy not established
≥ 1 year:
1-6 years: 12mg/kg intravenous every 24 hours infusion over 60mins
7-11 years: 9mg/kg intravenous every 24 hours infusion over 30mins
12-17 years:7mg/kg intravenous every 24 hours infusion over 30mins
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
Future Trends
In this medical condition the bacteria are present in the bloodstream. This infection generally seen in various body parts like urinary tract and skin.Â
Bacteremia is classified as transient and persistent category.Â
Transient bacteremia is common. It seen during dental procedures and is usually asymptomatic and self-limited. But persistent bacteremia occurs when bacteria present in the bloodstream for a longer time.Â
The incidence is noted higher in elderly patients and in hospitalized patients for e.g., intensive care units.Â
In developed countries gram-positive bacteria are common causes of bacteremia. Gram-negative bacteria are more common in developing countries. Â
Â
Bacteremia can be caused by various factors. It includes infections in different regions of the body and invasive medical procedures.Â
Once bacteria enter the bloodstream. They can interact with immune cells which triggers an inflammatory reaction. This leads to the release of cytokines can cause fever and chills.Â
This disorder need to be treated otherwise it may cause the sepsis. It is a potentially fatal illness.Â
Â
A gram-positive bacterium is a common cause of bacteremia. It is observed in hospitalized patients and those with weakened immune systems.Â
This disorder is responsible to cause pneumonia, meningitis, and UTI.Â
Old age people have higher chances to die from bacteremia. In case of underlying medical disorders the patients are at a higher risk of complications.Â
The severity of sickness while examination can have an impact on the prognosis of patients.Â
Â
It depends on the patient’s age. In neonates and young infants, it presents with nonspecific symptoms such as fever and poor feeding. Â
FeverÂ
TachycardiaÂ
Joint pain Â
Respiratory distressÂ
Hypotension Â
Skin rashÂ
Abdominal painÂ
Acute onset of symptoms observes a more severe and rapidly progressing infection. In slower onset of symptoms may show a chronic or subacute infection.Â
Bacterial infections Â
Parasitic infectionsÂ
Fungal infections Â
Viral infectionsÂ
The diagnosis of bacterium illness depends on blood cultures. The empirical broad-spectrum antibiotics are used as first-line therapy. Â
In definitive therapy phase it minimizes the use of broad-spectrum antibiotics and reduce the risk of antibiotic resistance. Â
Antibiotic resistance and associated consequences can be reduced by using shorter doses of antibiotics when affordable. Â
Pediatrics, General
Source control helps prevent ongoing introduction of bacteria into the bloodstream. Â
Non-pharmacological supportive measures, such as fluid resuscitation and maintenance are important for stabilizing patients with bacteremia. Â
To maintain optimal nutrition for patients it supports the immune system and overall recovery. Â
Fever is a common symptom of bacteremia. For that the cooling blankets and tepid sponge baths are used to manage fever and improve patient comfort. Â
Pediatrics, General
Cephalosporins belongs to the class of antibiotics which are used in the treatment of bacteremia. It will block the production of bacterial cell walls. Â
Pediatrics, General
Blood cultures are a critical diagnostic procedure in the evaluation of bacteremia. In some cases, endoscopy may be used to identify and treat infections in the gastrointestinal or respiratory tracts.Â
In cases of soft tissue infections, surgical debridement may be performed to remove infected tissue and promote healing. Â
Pediatrics, General
In the initial phase the physician should obtain blood cultures before starting antibiotics to identify the causative organism. Evaluate the patient’s clinical status, signs, and symptoms of infection. Then adjust therapy based on culture results and susceptibility testing. Â
Identify and address the source of infection for e.g., abscess, infected catheter, dental infection. Schedule follow-up appointments to monitor for relapse or recurrence.Â
In this medical condition the bacteria are present in the bloodstream. This infection generally seen in various body parts like urinary tract and skin.Â
Bacteremia is classified as transient and persistent category.Â
Transient bacteremia is common. It seen during dental procedures and is usually asymptomatic and self-limited. But persistent bacteremia occurs when bacteria present in the bloodstream for a longer time.Â
The incidence is noted higher in elderly patients and in hospitalized patients for e.g., intensive care units.Â
In developed countries gram-positive bacteria are common causes of bacteremia. Gram-negative bacteria are more common in developing countries. Â
Â
Bacteremia can be caused by various factors. It includes infections in different regions of the body and invasive medical procedures.Â
Once bacteria enter the bloodstream. They can interact with immune cells which triggers an inflammatory reaction. This leads to the release of cytokines can cause fever and chills.Â
This disorder need to be treated otherwise it may cause the sepsis. It is a potentially fatal illness.Â
Â
A gram-positive bacterium is a common cause of bacteremia. It is observed in hospitalized patients and those with weakened immune systems.Â
This disorder is responsible to cause pneumonia, meningitis, and UTI.Â
Old age people have higher chances to die from bacteremia. In case of underlying medical disorders the patients are at a higher risk of complications.Â
The severity of sickness while examination can have an impact on the prognosis of patients.Â
Â
It depends on the patient’s age. In neonates and young infants, it presents with nonspecific symptoms such as fever and poor feeding. Â
FeverÂ
TachycardiaÂ
Joint pain Â
Respiratory distressÂ
Hypotension Â
Skin rashÂ
Abdominal painÂ
Acute onset of symptoms observes a more severe and rapidly progressing infection. In slower onset of symptoms may show a chronic or subacute infection.Â
Bacterial infections Â
Parasitic infectionsÂ
Fungal infections Â
Viral infectionsÂ
The diagnosis of bacterium illness depends on blood cultures. The empirical broad-spectrum antibiotics are used as first-line therapy. Â
In definitive therapy phase it minimizes the use of broad-spectrum antibiotics and reduce the risk of antibiotic resistance. Â
Antibiotic resistance and associated consequences can be reduced by using shorter doses of antibiotics when affordable. Â
Pediatrics, General
Source control helps prevent ongoing introduction of bacteria into the bloodstream. Â
Non-pharmacological supportive measures, such as fluid resuscitation and maintenance are important for stabilizing patients with bacteremia. Â
To maintain optimal nutrition for patients it supports the immune system and overall recovery. Â
Fever is a common symptom of bacteremia. For that the cooling blankets and tepid sponge baths are used to manage fever and improve patient comfort. Â
Pediatrics, General
Cephalosporins belongs to the class of antibiotics which are used in the treatment of bacteremia. It will block the production of bacterial cell walls. Â
Pediatrics, General
Blood cultures are a critical diagnostic procedure in the evaluation of bacteremia. In some cases, endoscopy may be used to identify and treat infections in the gastrointestinal or respiratory tracts.Â
In cases of soft tissue infections, surgical debridement may be performed to remove infected tissue and promote healing. Â
Pediatrics, General
In the initial phase the physician should obtain blood cultures before starting antibiotics to identify the causative organism. Evaluate the patient’s clinical status, signs, and symptoms of infection. Then adjust therapy based on culture results and susceptibility testing. Â
Identify and address the source of infection for e.g., abscess, infected catheter, dental infection. Schedule follow-up appointments to monitor for relapse or recurrence.Â

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