fbpx

Chondronecrosis of Larynx

Updated : May 28, 2024





Background

Chondronecrosis larynx a rare condition which occurs due to death or necrosis of laryngeal cartilage. 

Larynx functions include voice production, cough, airway protection, and breathing. 

Causes of dysphonia include intubation, laryngeal trauma, infections, and autoimmune disorders. 

Pressure from tube can cause tissue to damage the necrosis of larynx. 

Epidemiology

Early tumors had 2% incidence rate while advanced tumors treated with 4500 to 6000 rads.  

Study incidence higher than clinically observed cases is reaching to 26%.  

Relapsing polychondritis causes laryngotracheal instability seen in patients and Scientist Keene conducted study in 1982 on laryngeal specimens using whole organ. 

Anatomy

Pathophysiology

Edema from permeability increases and lymphatic drainage decrease limits nutrients.  

Perichondrial membrane breakdown exposes ischemic cartilage to bacteria, causing chondronecrosis if not treated promptly.
Late identification and untreated infection leads to chondronecrosis and
Immune response activation can lead chondritis. 

Etiology

Endotracheal tube pressure harms laryngeal structures that cause ischemia, inflammation, and cartilage necrosis.  

Head and neck cancer radiation patients face higher larynx chondronecrosis risk.  

Caustic substances or chemicals can damage larynx mucosa and cartilage. 

Genetics

Prognostic Factors

Cases due to reversible factors like trauma or intubation improve.  

Extensive cartilage necrosis linked to worse outcomes than limited necrosis.
Quickly identify and treat complications to improve larynx chondronecrosis outcomes. 

Clinical History

Adults, middle-aged and elderly individuals most commonly report larynx chondronecrosis. 

Physical Examination

Visualization of the Larynx 

Laryngeal Examination 

Respiratory Assessment 

Neck Examination 

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Chronic chondronecrosis of the larynx can develop slowly over time, potentially linked to factors like prolonged intubation or autoimmune diseases. 

Chronic cases may worsen suddenly in patients with underlying chondronecrosis of the larynx. 

Differential Diagnoses

Laryngitis 

Vocal Cord Paralysis 

Laryngeal Cancer 

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

Early intervention procedures include speech-language therapy, occupational therapy, and applied behavior analysis to give better results in given treatment. 

Rehabilitation therapies such as voice therapy, swallowing therapy, and respiratory exercises are beneficial for patients with chondronecrosis. 

Appointments with medical physicians and preventing recurrence of disorder is an ongoing life-long effort. 

 

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Use of a non-pharmacological approach Chondronecrosis of Larynx

Patients with chondronecrosis should avoid exposure to environmental irritants that cause delays in the healing process. 

Education should be given to individuals about cautious with activities that could cause chondronecrosis. 

Patient should stay in adequate conditions with good ventilation, air quality and a clean environment. 

Use of Analgesics in treatment of Chondronecrosis of Larynx

Acetaminophen: It is effective to relieve mild to moderate pain which reduces prostaglandin production in the central nervous system. 

Use of fluoroquinolone for treatment of Chondronecrosis of Larynx

Ciprofloxacin: It is effective against many bacteria, especially in respiratory infections. 

Use of Intervention with a procedure in treating Chondronecrosis of Larynx

Laryngoscopy: It is a diagnostic procedure to view the larynx and evaluate tissue damage like chondronecrosis. It is performed with help of flexible or rigid endoscopes through the nose or mouth. 

Use of phases in managing Chondronecrosis of Larynx

In the initial diagnosis phase, the physician assesses symptoms related to necrosis, including laryngoscopy and biopsy to confirm diagnosis of chondronecrosis of larynx. 

In the supportive care and preventive measure phase all necessary steps should be taken by physicians to enhance the quality of life of the patient. 

The long-term management phase is important phase involves continuous monitoring and progress of treatment. 

Medication

Media Gallary

Chondronecrosis of Larynx

Updated : May 28, 2024




Chondronecrosis larynx a rare condition which occurs due to death or necrosis of laryngeal cartilage. 

Larynx functions include voice production, cough, airway protection, and breathing. 

Causes of dysphonia include intubation, laryngeal trauma, infections, and autoimmune disorders. 

Pressure from tube can cause tissue to damage the necrosis of larynx. 

Early tumors had 2% incidence rate while advanced tumors treated with 4500 to 6000 rads.  

Study incidence higher than clinically observed cases is reaching to 26%.  

Relapsing polychondritis causes laryngotracheal instability seen in patients and Scientist Keene conducted study in 1982 on laryngeal specimens using whole organ. 

Edema from permeability increases and lymphatic drainage decrease limits nutrients.  

Perichondrial membrane breakdown exposes ischemic cartilage to bacteria, causing chondronecrosis if not treated promptly.
Late identification and untreated infection leads to chondronecrosis and
Immune response activation can lead chondritis. 

Endotracheal tube pressure harms laryngeal structures that cause ischemia, inflammation, and cartilage necrosis.  

Head and neck cancer radiation patients face higher larynx chondronecrosis risk.  

Caustic substances or chemicals can damage larynx mucosa and cartilage. 

Cases due to reversible factors like trauma or intubation improve.  

Extensive cartilage necrosis linked to worse outcomes than limited necrosis.
Quickly identify and treat complications to improve larynx chondronecrosis outcomes. 

Adults, middle-aged and elderly individuals most commonly report larynx chondronecrosis. 

Visualization of the Larynx 

Laryngeal Examination 

Respiratory Assessment 

Neck Examination 

Chronic chondronecrosis of the larynx can develop slowly over time, potentially linked to factors like prolonged intubation or autoimmune diseases. 

Chronic cases may worsen suddenly in patients with underlying chondronecrosis of the larynx. 

Laryngitis 

Vocal Cord Paralysis 

Laryngeal Cancer 

Early intervention procedures include speech-language therapy, occupational therapy, and applied behavior analysis to give better results in given treatment. 

Rehabilitation therapies such as voice therapy, swallowing therapy, and respiratory exercises are beneficial for patients with chondronecrosis. 

Appointments with medical physicians and preventing recurrence of disorder is an ongoing life-long effort. 

 

Patients with chondronecrosis should avoid exposure to environmental irritants that cause delays in the healing process. 

Education should be given to individuals about cautious with activities that could cause chondronecrosis. 

Patient should stay in adequate conditions with good ventilation, air quality and a clean environment. 

Acetaminophen: It is effective to relieve mild to moderate pain which reduces prostaglandin production in the central nervous system. 

Ciprofloxacin: It is effective against many bacteria, especially in respiratory infections. 

Laryngoscopy: It is a diagnostic procedure to view the larynx and evaluate tissue damage like chondronecrosis. It is performed with help of flexible or rigid endoscopes through the nose or mouth. 

In the initial diagnosis phase, the physician assesses symptoms related to necrosis, including laryngoscopy and biopsy to confirm diagnosis of chondronecrosis of larynx. 

In the supportive care and preventive measure phase all necessary steps should be taken by physicians to enhance the quality of life of the patient. 

The long-term management phase is important phase involves continuous monitoring and progress of treatment. 

Free CME credits

Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.

Digital Certificate PDF

On course completion, you will receive a full-sized presentation quality digital certificate.

medtigo Simulation

A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.

medtigo Points

medtigo points is our unique point redemption system created to award users for interacting on our site. These points can be redeemed for special discounts on the medtigo marketplace as well as towards the membership cost itself.
 
  • Registration with medtigo = 10 points
  • 1 visit to medtigo’s website = 1 point
  • Interacting with medtigo posts (through comments/clinical cases etc.) = 5 points
  • Attempting a game = 1 point
  • Community Forum post/reply = 5 points

    *Redemption of points can occur only through the medtigo marketplace, courses, or simulation system. Money will not be credited to your bank account. 10 points = $1.

All Your Certificates in One Place

When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.

Our Certificate Courses

Up arrow