250-350mg every 8 hours at bedtime. Do not exceed 2 to 3 weeks
In individuals who have a history of long-term usage, taper gradually (over 14 days) to prevent withdrawal symptoms, including sleeplessness, anxiety, or irritability
Initial dose: 2mg orally thrice a day whenever necessary. Do not exceed three doses per day
Maintenance dose: Adjust dosage in increments of 2 to 4 mg daily, with a minimum interval of 1 to 4 days between dose adjustments, until the desired effect is achieved.
Do not exceed 36mg/day.
To gradually discontinue, reduce by 2-4 mg daily.
Dose Adjustments
Renal Impairment
CrCl <25 mL/min: Clearance decreased >50%
Creatinine Clearance Rate (CrCl) >25 mL/min: Not Studied; Caution Is Advised
Apply on the site of pain 3-4 times daily for 3-4 weeks
After evaluation, if the efficacy is found to decrease, do not increase more than 4 applications each day
Indicated for relief from symptoms of mild-moderate pain that occurs due to musculoskeletal disorders in combination with physical therapy, rest, and other measures
0.5-1 tablet orally 3-4 times each day
<16 years: Safety and efficacy not established
>16 years: 250-350mg every 8 hours at bedtime. Do not exceed 2 to 3 weeks
In individuals who have a history of long-term usage, taper gradually (over 14 days) to prevent withdrawal symptoms, including sleeplessness, anxiety, or irritability
Indicated for relief from symptoms of mild-moderate pain that occurs due to musculoskeletal disorders in combination with physical therapy, rest, and other measures
0.5-1 tablet orally 3-4 times each day
Safety and efficacy are not seen in children less than 12 years
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