Chronic Sialorrhea

Updated: July 17, 2023

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

incobotulinumtoxinA

the recommended total dose is 100 units per therapy session; split the dose in a 3:2 ratio between the parotid and submandibular glands; Don't exceed the cumulative dose of 400 units every treatment session
Dosing by glands
30 units per side for the parotid glands; a total of 60 units.
20 units per side for the submandibular gland(s); a total of 40 units
50 units on each side, totaling 100 units for both glands
Recurring treatments should not occur more frequently than every 16 weeks and should be dependent on the patient's real clinical needs.

incobotulinumtoxinA

<2 years or <12 kg: Safety and efficacy not established
≥2 years and ≥12 kg
Parotid and submandibular glands receive doses based on body weight (a ratio of 3:2)
Depending on the patient's clinical necessity, repeat treatments no more frequently than every 16 weeks.
Parotid gland
6 units (0.24 mL) per side for 12 to 15 kg
9 units (0.36 mL) each side for 15 to 19 kg
12 units (0.48 mL) each side for 19 to 23 kg
15 units (0.6 mL) per side for 23 to 27 kg
18 units (0.72 mL) per side for 27 to 30 kg.
22.5 units (0.9 mL) per side for 30 kg
submandibular gland (each side)
4 units (0.16 mL) per side for 12 to 15 kg
6 units (0.24 mL) per side for 15 to 19 kg
8 units (0.32 mL) per side for 19 to 23 kg
10 units (0.4 mL) per side for 23 to 27 kg
12 units (0.48 mL) per side for 27 to 30 kg.
15 units (0.6 mL) per side for 30 kg.
Total dose, both glands, both sides
12 to 15 kg: 20 units
15 to 19 kg: 30 units
19 to 23 kg: 40 units
23 to 27 kg: 50 units
27 to 30 kg: 60 units
30 kg: 75 units