Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Background
Corticosteroid-responsive dermatoses is a skin conditions that improve and treat skin problems with the use of corticosteroids. Â
Dermatoses is used to describe skin defect or lesion. Corticosteroids are anti-inflammatory medications used to reduce inflammation and increase the immune response. Â
Corticosteroids are available in the form of topical creams, ointments, and lotions.Â
Types of Dermatoses:Â Â
Atopic dermatitisÂ
Contact dermatitisÂ
Seborrheic dermatitisÂ
PsoriasisÂ
Epidemiology
Eczema is seen in 10% to 20% of cases in children and 1% to 3% in adults. While psoriasis affects 2% to 3% individuals of the global population. Â
Atopic dermatitis affects 15% to 20% in children and 1% to 3% in adults.Â
Skin cancer cases are seen in sun-exposed regions such as Australia, New Zealand, and Europe. Skin diseases cause discomfort, distress, and social stigma that affects patient personal life. Â
Anatomy
Pathophysiology
Filaggrin gene mutations give weak skin barrier to produce allergens and inflammation.Â
Keratinocyte dysfunction causes skin scaling and thickening. Inflammatory response worsens tissue damage.Â
Autoantibodies attack desmoglein in skin cells and causes adhesion loss and blisters. Genetic mutations disrupt keratinization causes skin barrier dysfunction, increased water loss, and infection vulnerability.Â
Etiology
Genetics
Prognostic Factors
Severe diseases with large lesions need intensive treatment for improvement.Â
Identify and avoid irritant or allergen for better prognosis outcome.Â
Early-onset skin conditions are chronic in nature thus difficult to treat.Â
E.g., eczema and psoriasisÂ
Emotional stress can worsen skin conditions and treatment outcomes.Â
Clinical History
Corticosteroid responsive dermatoses affect individuals of all age groups from infants to adults.Â
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
For acute dermatoses:Â
Severe itching, pain, redness, and swellingÂ
For chronic dermatoses:Â
Long-lasting, dry and scaly skin,Â
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Patients should identify and avoid triggers including allergens and irritants.Â
It controls symptoms, promotes healing and minimizes recurrence to manage chronic condition. Â
Topical corticosteroids are used in the treatment of eczema, psoriasis, and contact dermatitis.Â
Oral corticosteroids are indicated to treat severe eczema and lupus erythematosus.Â
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-non-pharmacological-approach-for-corticosteroid-responsive-dermatoses
Patient should use mild soaps/lotions and follow good hygiene practices.Â
Patient should stay in dry environments to maintain skin moisture and prevent dryness.Â
Use long sleeves and skin protecting cloths during summer season or when exposed to sunlight.Â
Patient should wear soft and cotton cloths and avoid waring wool/synthetic fibres cloths.Â
Proper education and awareness about corticosteroid responsive dermatoses should be provided and its related causes with management strategies.Â
Appointments with a dermatologist and preventing recurrence of disorder is an ongoing life-long effort.
use-of-topical-corticosteroids
It decreases inflammation to stabilize leukocyte lysosomal membranes of destructive acid hydrolases.Â
It reduces swelling, redness, itching and rashes caused due to these skin conditions.Â
Betamethasone dipropionate:Â
It has potent glucocorticoid activity and works as corticosteroid Hormone Receptor Agonist.Â
use-of-intervention-with-a-procedure-in-treating-corticosteroid-responsive-dermatoses
Phototherapy is indicated to treat psoriasis, eczema, and vitiligo.Â
use-of-phases-in-managing-corticosteroid-responsive-dermatoses
In the initial diagnosis phase, evaluation of medical history, physical examination and diagnostic test to confirm diagnosis.Â
Pharmacologic therapy is effective in the treatment phase as it includes use of topical corticosteroids and therapies.Â
The regular follow-up visits with the dermatologist are schedule to check the improvement of patients along with treatment response.Â
Medication
Gels
Topically applied
every 12 hours
Apply a thin film topically to the affected area
Administer to the affected region every 6 to 12 hours; stop treatment once control is established
If there is no improvement after two weeks, re-evaluate the diagnosis
Apply a slight coating topically once daily or every 12 hours as needed
Apply cream or lotion every 12 hours; stop treatment when control is attained.
If there is no improvement after two weeks, re-evaluate the diagnosis
Do not use it for more than three weeks
hydrocortisone probutate topicalÂ
Medium-potency corticosteroid used to treat dermatoses' inflammatory and itchy symptoms
Depending on the severity of the condition, just apply a small amount (daily or twice a day) to the affected area
fusidic acid and betamethasoneÂ
Indicated for Secondary infection in corticosteroid-responsive dermatoses
:
Apply to the affected area twice daily. Do not exceed 14 days of treatment.
Apply a thin layer to the affected area up to two to four times in a day
Dosing modification
Renal Impairment
No dose modification required
Hepatic Impairment
No dose modification required
Apply to the areas of affected skin as ointment/cream of concentration 0.05 %
Apply to the affected area twice or thrice a day
Apply a tiny amount to the affected region twice or thrice a day.
Once the improvement has occurred, apply once daily or less often.
- 100
Topical
0.25% caproate or 0.25% of pivalate or alcohol-containing cream to be applied on the affected area twice daily
Cream/foam: Apply a thin coat to the affected regions every 12 hours and gently massage it in. Do not apply more than 50 g/week.
Lotion: Apply to damaged skin areas twice a day and rub in; do not use more than 50 g per week
Apply to the areas of affected skin as ointment/cream of concentration 0.05%
Apply gel, cream, solution or ointment 2 to 4 times a day on the basis of severity of the disease
Apply 0.2 % ointment or cream one-two times a day
Apply 0.2 % ointment or cream one-two times a day
Dosing considerations
Use caution while using some plastic films since they may be flammable.:
Cream, ointment, solution: apply a thin coating to the afflicted region between two and four times each day
apply thin film ointment to the affected area twice a day
Apply a thin film onto the affected area every 8-12 hours
Apply to the affected area twice or thrice a day
Gels
Topically applied
every 12 hrs
<18 years: Not recommended
>18 years: Apply a thin film topically to the affected area
Administer to the affected region every 6 to 12 hours; stop treatment once control is established
If there is no improvement after two weeks, re-evaluate the diagnosis
Apply a slight coating topically once daily or every 12 hours as needed
<12 months: Safety and efficacy not established
>12 months: Apply cream every 12 hours
>10 years: Apply the ointment every 12 hours
Do not use it for more than three weeks
Keep dosages to the absolute lowest required for effective treatment
If there is no improvement after two weeks, re-evaluate the diagnosis
Apply the least amount of cream on the affected area, as children are prone to systemic toxicity
fusidic acid and betamethasoneÂ
Indicated for Secondary infection in corticosteroid-responsive dermatoses
:
Children more than 6 years and adults:
Apply to the affected area twice daily. Do not exceed 14 days of treatment.
For Children and Adolescents:
Apply a thin layer to the affected area up to two to four times in a day
Apply to the affected area twice or thrice a day
Apply a tiny amount to the affected region twice or thrice a day.
Once the improvement has occurred, apply once daily or less often.
Below 12 years
Safety and efficacy not established
Above 12 years (cream/foam)
Apply a thin layer to the affected regions every 12 hours and gently massage it in. Do not apply more than 50 g per week.
Scalp:
Below 12 years
Safety and efficacy not established
Above 12 years (foam)
Apply to affected area in scalp every 12hr for 2 weeks; should not exceed 50 g or 50 mL per week
Dosing considerations
Use caution while using some plastic films since they may be flammable. :
Children and adolescents
Cream, ointment, solution: apply a thin coating to the afflicted region between two and three times each day
Apply a thin film onto the affected area every 12 hours
Avoid the face and use the minimum amount necessary
Apply to the affected area twice or thrice a day
Future Trends
Corticosteroid-responsive dermatoses is a skin conditions that improve and treat skin problems with the use of corticosteroids. Â
Dermatoses is used to describe skin defect or lesion. Corticosteroids are anti-inflammatory medications used to reduce inflammation and increase the immune response. Â
Corticosteroids are available in the form of topical creams, ointments, and lotions.Â
Types of Dermatoses:Â Â
Atopic dermatitisÂ
Contact dermatitisÂ
Seborrheic dermatitisÂ
PsoriasisÂ
Eczema is seen in 10% to 20% of cases in children and 1% to 3% in adults. While psoriasis affects 2% to 3% individuals of the global population. Â
Atopic dermatitis affects 15% to 20% in children and 1% to 3% in adults.Â
Skin cancer cases are seen in sun-exposed regions such as Australia, New Zealand, and Europe. Skin diseases cause discomfort, distress, and social stigma that affects patient personal life. Â
Filaggrin gene mutations give weak skin barrier to produce allergens and inflammation.Â
Keratinocyte dysfunction causes skin scaling and thickening. Inflammatory response worsens tissue damage.Â
Autoantibodies attack desmoglein in skin cells and causes adhesion loss and blisters. Genetic mutations disrupt keratinization causes skin barrier dysfunction, increased water loss, and infection vulnerability.Â
Severe diseases with large lesions need intensive treatment for improvement.Â
Identify and avoid irritant or allergen for better prognosis outcome.Â
Early-onset skin conditions are chronic in nature thus difficult to treat.Â
E.g., eczema and psoriasisÂ
Emotional stress can worsen skin conditions and treatment outcomes.Â
Corticosteroid responsive dermatoses affect individuals of all age groups from infants to adults.Â
For acute dermatoses:Â
Severe itching, pain, redness, and swellingÂ
For chronic dermatoses:Â
Long-lasting, dry and scaly skin,Â
Patients should identify and avoid triggers including allergens and irritants.Â
It controls symptoms, promotes healing and minimizes recurrence to manage chronic condition. Â
Topical corticosteroids are used in the treatment of eczema, psoriasis, and contact dermatitis.Â
Oral corticosteroids are indicated to treat severe eczema and lupus erythematosus.Â
Dermatology, General
Patient should use mild soaps/lotions and follow good hygiene practices.Â
Patient should stay in dry environments to maintain skin moisture and prevent dryness.Â
Use long sleeves and skin protecting cloths during summer season or when exposed to sunlight.Â
Patient should wear soft and cotton cloths and avoid waring wool/synthetic fibres cloths.Â
Proper education and awareness about corticosteroid responsive dermatoses should be provided and its related causes with management strategies.Â
Appointments with a dermatologist and preventing recurrence of disorder is an ongoing life-long effort.
Dermatology, General
It decreases inflammation to stabilize leukocyte lysosomal membranes of destructive acid hydrolases.Â
It reduces swelling, redness, itching and rashes caused due to these skin conditions.Â
Betamethasone dipropionate:Â
It has potent glucocorticoid activity and works as corticosteroid Hormone Receptor Agonist.Â
Dermatology, General
Phototherapy is indicated to treat psoriasis, eczema, and vitiligo.Â
In the initial diagnosis phase, evaluation of medical history, physical examination and diagnostic test to confirm diagnosis.Â
Pharmacologic therapy is effective in the treatment phase as it includes use of topical corticosteroids and therapies.Â
The regular follow-up visits with the dermatologist are schedule to check the improvement of patients along with treatment response.Â
Corticosteroid-responsive dermatoses is a skin conditions that improve and treat skin problems with the use of corticosteroids. Â
Dermatoses is used to describe skin defect or lesion. Corticosteroids are anti-inflammatory medications used to reduce inflammation and increase the immune response. Â
Corticosteroids are available in the form of topical creams, ointments, and lotions.Â
Types of Dermatoses:Â Â
Atopic dermatitisÂ
Contact dermatitisÂ
Seborrheic dermatitisÂ
PsoriasisÂ
Eczema is seen in 10% to 20% of cases in children and 1% to 3% in adults. While psoriasis affects 2% to 3% individuals of the global population. Â
Atopic dermatitis affects 15% to 20% in children and 1% to 3% in adults.Â
Skin cancer cases are seen in sun-exposed regions such as Australia, New Zealand, and Europe. Skin diseases cause discomfort, distress, and social stigma that affects patient personal life. Â
Filaggrin gene mutations give weak skin barrier to produce allergens and inflammation.Â
Keratinocyte dysfunction causes skin scaling and thickening. Inflammatory response worsens tissue damage.Â
Autoantibodies attack desmoglein in skin cells and causes adhesion loss and blisters. Genetic mutations disrupt keratinization causes skin barrier dysfunction, increased water loss, and infection vulnerability.Â
Severe diseases with large lesions need intensive treatment for improvement.Â
Identify and avoid irritant or allergen for better prognosis outcome.Â
Early-onset skin conditions are chronic in nature thus difficult to treat.Â
E.g., eczema and psoriasisÂ
Emotional stress can worsen skin conditions and treatment outcomes.Â
Corticosteroid responsive dermatoses affect individuals of all age groups from infants to adults.Â
For acute dermatoses:Â
Severe itching, pain, redness, and swellingÂ
For chronic dermatoses:Â
Long-lasting, dry and scaly skin,Â
Patients should identify and avoid triggers including allergens and irritants.Â
It controls symptoms, promotes healing and minimizes recurrence to manage chronic condition. Â
Topical corticosteroids are used in the treatment of eczema, psoriasis, and contact dermatitis.Â
Oral corticosteroids are indicated to treat severe eczema and lupus erythematosus.Â
Dermatology, General
Patient should use mild soaps/lotions and follow good hygiene practices.Â
Patient should stay in dry environments to maintain skin moisture and prevent dryness.Â
Use long sleeves and skin protecting cloths during summer season or when exposed to sunlight.Â
Patient should wear soft and cotton cloths and avoid waring wool/synthetic fibres cloths.Â
Proper education and awareness about corticosteroid responsive dermatoses should be provided and its related causes with management strategies.Â
Appointments with a dermatologist and preventing recurrence of disorder is an ongoing life-long effort.
Dermatology, General
It decreases inflammation to stabilize leukocyte lysosomal membranes of destructive acid hydrolases.Â
It reduces swelling, redness, itching and rashes caused due to these skin conditions.Â
Betamethasone dipropionate:Â
It has potent glucocorticoid activity and works as corticosteroid Hormone Receptor Agonist.Â
Dermatology, General
Phototherapy is indicated to treat psoriasis, eczema, and vitiligo.Â
In the initial diagnosis phase, evaluation of medical history, physical examination and diagnostic test to confirm diagnosis.Â
Pharmacologic therapy is effective in the treatment phase as it includes use of topical corticosteroids and therapies.Â
The regular follow-up visits with the dermatologist are schedule to check the improvement of patients along with treatment response.Â
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