Cough

Updated: June 8, 2023

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Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

hydrocodone and homatropine 

5 mg/1.5 mg orally every 4-6 hours 



codeine 

indicated for Cough (Off-label) The dosage is 7.5-30 mg orally every 4-6 hours as needed



codeine and pseudoephedrine 

5 to 10 ml orally every4-6 times a day; should not exceed more than 40mL daily



codeine, chlorpheniramine and phenylephrine 

and congestion:

5 to 10 mL orally every 4-6 times a day, up to 40 mL daily



codeine/acetaminophen 

15 to 30 mg of codeine/dose taken orally every 4 to 6 hours and the maximum daily dose is 360 mg of codeine or 4 g of acetaminophen
Dosage Modifications
Renal impairment: Use cautiously
Hepatic impairment: chronic use should be avoided
Dosing Consideration
Assess need for naloxone upon initiating and renewing treatment
Availability of naloxone for emergency treatment of opioid overdose



codeine/guaifenesin 


Indicated for Cough
5 ml of (6.3mg of codeine/100mg of guaifenesin)/5mL orally four-six times a day. It should not exceed 90 ml in a day
5 ml-7.5 ml of (7.5 mg of codeine/225 mg of guaifenesin)/5mL orally six times a day. It should not exceed 45 ml in a day
10 ml of (8 mg-10 mg of codeine/100 mg-200 mg of guaifenesin)/5mL orally six times a day. It should not exceed 60 ml in a day
5 ml of (10 mg of codeine/300 mg of guaifenesin)/5mL orally six times a day. It should not exceed 40 ml in a day
5 ml of (20 mg of codeine/200mg of guaifenesin)/5mL orally four-six times a day. It should not exceed 30 ml in a day
It is used for temporary relief from cough which is caused by throat irritation and bronchial irritation



chlophedianol and dexbrompheniramine 

Oral: 25 mg of chlophedianol/2 mg of dexbrompheniramine (10 mL) every 4 times a day (Maximum: 100 mg of chlophedianol/8 mg of dexbrompheniramine (40 mL) per day)



Dose Adjustments

Dosing modifications
Renal impairment

Dose adjustment is not necessary
Hepatic impairment
Dose adjustment is not necessary

clofedanol 

Administer 25mg orally three to four times a day



camphor 



Dose Adjustments

A thick layer of 4.7-5.3% is applied as an ointment on the throat & chest

soapwort 

1 to 2 grams of extract to be taken orally every day or 1.5 grams root to be taken orally every day



amylmetacresol/dextromethorphan hydrobromide 

Put 1 lozenge in the mouth and sucked slowly every 4 hours
Not more than 12 lozenges in a day



guaiacol glycerol ether 

Sustained release formulation: Take 600-1200 mg as an oral dose twice daily with maximum daily dose of 2.4 grams/day
Immediate release formulation: Take 200-400 mg as an oral dose six times daily, with a maximum daily dose of 2.4 grams/day



isoaminile 

Take a dose of 40 to 80 mg with a maximum of five doses in a day



pentoxyverine 

Take an oral dose of 5 to 10 ml in each 12 hours



myrtol 

In acute cases: Take a dose of 300 mg orally 3 to 4 times in a day
In chronic cases: Take a dose of 300 mg orally two times in a day



letosteine 

50 mg orally thrice a day



levodropropizine 

60 mg orally taken thrice a day for not more than a week



Dose Adjustments

Dosage modifications
Hepatic impairment: Contraindicated in Severe cases

normethadone/hydroxyephedrine 

Take around 15 drops orally two time a day
Dose should not be more than 30 drops in a day



ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol 

Shake the bottle well before use and take a dose as per physician advised



ambroxol/salbutamol 

Take a dose of 10 to 20 ml orally for three times in a day



dextropropoxyphene/dexchlorpheniramine maleate/bromhexine 

Shake the bottle well before use and take a dose as per physician advised



triprolidine/dextromethorphan   

Shake the bottle well before use and take oral dose as per physicians advised



opium tincture, squill oxymel 

Take 5 ml of syrup 4 times a day



levomenthol 

Indicated as a cough suppressant:


Administer 10ml every 3 to 4 hours.
Do not exceed 6 doses in a day.



butamirate citrate 

Take a dose of 15 ml orally up to four times in a day



camphor/eucalyptus oil/menthol 

Apply a thick layer topically over the throat and chest 3 times daily



codeine, phenylephrine, and promethazine 

5 mL orally every 4 to 6 hours, should not exceed more than 30 mL/24 hours



iceland moss 

With tea
Take 1 cup several times in a day
Steep dose of 1.5 to 3 g of the dried plant in 150 ml boiling water up to 5-10 minutes



ammonium chloride/diphenhydramine hydrochloride/levomenthol 

Indicated for Symptomatic relief of chesty cough
Consume between 5ml and 10ml every 4 hours
At bedtime, start with 10ml for improved sleep quality, then take 10ml every 6 hours afterward Important: do not exceed four doses within 24 hours
Please, note that two 5ml Spoonfuls equal one dose



benzonatate 

The recommended oral doses are 100 mg, 150 mg, and 200 mg, to be taken every 8 hours
The maximum daily dosage should not exceed 600 mg



lemongrass 

1-2 spoons tea of lemongrass/6 oz of water



 

hydrocodone and homatropine 

5 mg/1.5 mg orally every 4-6 hours 



codeine 

off-label:

Age(≥ 12 years)- The dosage is 7.5-30 mg taken orally every 4-6 hours as needed
Adjust the dose gradually based on the level of pain relief experienced
It is important to administer the lowest effective dose for the shortest duration possible



codeine and pseudoephedrine 

Below 6 yrs: Not usually recommended
6 to 12 yrs: 2.5 to 5 mL orally every4-6 times a day; should not exceed more than 20mL in a day
Above 12 years: 5 to 10 ml orally every4-6 times a day; should not exceed more than 40mL in a day



codeine, chlorpheniramine and phenylephrine 

Below 2 yrs: Not usually recommended
2 to 6 yrs: 1.25 to 2.5 mL orally every 4-6 times a day, when necessary, up to 10 mL daily
6 to 12 yrs: 2.5 to 5 mL orally every 4-6 times a day, up to 20 mL daily
Above 12 yrs: 5 to 10 mL orally every 4-6 times a day, up to 40 mL daily



codeine/guaifenesin 


Indicated for Cough
Age >12 years
5 ml of (6.3mg of codeine/100mg of guaifenesin)/5mL orally four-six times a day. It should not exceed 90 ml in a day
5 ml-7.5 ml of (7.5 mg of codeine/225 mg of guaifenesin)/5mL orally six times a day. It should not exceed 45 ml in a day
10 ml of (8 mg-10 mg of codeine/100 mg-200 mg of guaifenesin)/5mL orally six times a day. It should not exceed 60 ml in a day
5 ml of (10 mg of codeine/300 mg of guaifenesin)/5mL orally six times a day. It should not exceed 40 ml in a day
5 ml of (20 mg of codeine/200mg of guaifenesin)/5mL orally four-six times a day. It should not exceed 30 ml in a day
It is used for temporary relief from cough which is caused by throat irritation and bronchial irritation
Age <12 years
Safety and efficacy not established



chlophedianol and dexbrompheniramine 

Children 6 to below 12 yrs: 5 mL orally every 4 times a day as required. Maximum daily dosage of 20 mL per day
Children above 12 yrs and Adolescents: 10 mL orally every 4 times a day as required. Maximum daily dosage of 40 mL per day



Dose Adjustments

Dosing modifications
Renal impairment

Dose adjustment is not necessary
Hepatic impairment
Dose adjustment is not necessary

amylmetacresol/dextromethorphan hydrobromide 

for 6 to 12 years old:
Put 1 lozenge in the mouth and sucked slowly every 4 hours
Not more than 6 lozenges in a day
for >12 years old:
Put 1 lozenge in the mouth and sucked slowly every 4 hours
Not more than 12 lozenges in a day



guaiacol glycerol ether 

Sustained release formulation: Age 2-5 years: Take 300 mg as an oral dose twice daily with maximum dose of 600 mg/day
Age 6-11 years: Take 600 mg as an oral dose twice daily with maximum dose of 1.2 grams/day
Age 12 years/older: Take 600 mg-1200 mg as an oral dose twice daily with maximum dose of 2.4 grams/day
Immediate release formulation: Age less than 2 years: Administer orally in 6 equally doses divided throughout the day at a rate of 12 mg/kg/day
Age 2-5 years: Take 50 mg-100 mg as an oral dose six times daily as required with a maximum dose of 600 mg/day
Age 6-11 years: Take 100-200 mg as an oral dose six times daily with a maximum dose of 1.2 grams/day
Age 12 years/older: Take 200 mg-400 mg as an oral dose six times daily with a maximum dose of 2.4 grams/day



pimethixene 

Indicated for cough suppressants
The recommended dose is 1.8 to 5.5 mg orally every day



pentoxyverine 

for 2 to 5 years old:
Take an oral dose of 1.25 to 2.5 ml in each 12 hours
for 6 to 11 years old:
Take an oral dose of 2.5to 5 ml in each 12 hours
for >12 years old:
Take an oral dose of 5 to 10 ml in each 12 hours



letosteine 

Above 5 years: 25 mg orally thrice a day



levodropropizine 

Above 2 years: 1 mg/kg thrice a day;
Above 12 years: 60 mg orally taken thrice a day for Not more than a week



Dose Adjustments

Dosage modifications
Hepatic impairment: Contraindicated in Severe cases

normethadone/hydroxyephedrine 

For adolescents >14 years old:
Take a dose of 15 drops two times a day
For children between 6 and 14 years old:
Take dose of 5 to 10 drops twice a day



ambroxol/salbutamol 

For <6 years old:
Take a dose of 5 to 10 ml orally for three times in a day
For 6 to 12 years old:
Take a dose of 10 ml orally for three times in a day



triprolidine/dextromethorphan   

For 13 to 18 years old:
Shake the bottle well before use and take oral dose as per physicians advised



guacetisal 

Off-label
1-2 suppositories, administered rectally for children under 6 years 2 suppositories administered rectally for children above 6 years Indications: indicated in the treatment of inflammations of airways in infants in acute diseases



camphor/eucalyptus oil/menthol 

Age: >2 years
Apply a thick layer topically over the throat and chest thrice daily



codeine, phenylephrine, and promethazine 

Below 12 years: Not recommended
12 years: 2.5-5 mL orally every 4 to 6 hours; should not exceed more than 30 mL/24 hours
Above 12 years: 5 mL orally every 4 to 6hours, should not exceed more than 30 mL/24 hours



codeine, phenylephrine, and promethazine 

Below 12 years: Not recommended
12 years: 2.5-5 mL orally every 4 to 6 hours; should not exceed more than 30 mL/24 hours
Above 12 years: 5 mL orally every 4 to 6hours, should not exceed more than 30 mL/24 hours



benzonatate 

>10 years Take 100 mg, 150 mg, or 200 mg orally every 8 hours
The maximum daily dose should not exceed 600 mg
Remember to swallow the medication whole and avoid chewing it



 

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Cough

Updated : June 8, 2023

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