Start with 500 lipase units/kg Orally per meal and titrate up to 2500 units/kg/meal depending on response; do not exceed 10,000 lipase units/kg daily or less than 4000 lipase units/gms fat intake daily.
Take Snacks along with 50% of the meal dosage.
High-dose Creon: For chronic pancreatitis and pancreatectomy, adults got a dosage of 72,000 lipase units/meal, whereas consuming a minimum of 100 g of fat daily in one clinical trial mentioned in prescribing information; lower starting dosages (i.e., 500 lipase units/kg daily) are consistent along with the Cystic Fibrosis guidelines.
Viokace
Start with 500 lipase units/kg Orally per meal and titrate up to 2500 units/kg/meal depending on response; do not exceed 10,000 lipase units/kg daily or less than 4000 lipase units/gms fat intake daily.
take Snacks along with 50% of the meal dosage.
Viokace should be taken with a Proton pump inhibitors

Creon/Zenpep
below 12 months: 3,000 lipase units/kg per 120 mL of formula/breast feeding; given before feeding; capsule ingredients should not be combined directly with formula or breast milk.
1 to 3 years: Start with 1,000 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2,500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
above 4 years: Start with 500 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
Pancreaze
Below 12 months: 2000 to 4000 lipase units/kg per 120 mL of formula/breast feeding; given before feeding; capsule ingredients should not be combined directly with formula or breast milk.
1 to 3 years: Start with 1,000 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2,500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
above 4 years: Start with 500 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
Should not exceed 10,000-unit lipase/kg daily or less than 4,000 lipase units/gms fat consumed daily.
Pertzye
Below 12 months: 4000 lipase units/kg per 120 mL of formula/breast feeding; given before feeding; capsule ingredients should not be combined directly with formula or breast milk.
1 to 4 years and weight above 8 kg: Start with 1,000 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2,500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
Above 4 years and weight above 16 kg: Start with 500 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
Ultresa
1to 4 years and weight above 14 kg: Start with 1,000 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2,500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
Above 4 years and weight above 28 kg: Start with 500 lipase units/kg/meal; should not exceed 10,000 lipase units/kg daily (2500 lipase units/kg/meal) or less than 4000 lipases units/gms fat consumed daily.
Viokace
Safety & effectiveness were not established
Recommendations from Consensus Report of Cystic Fibrosis Foundation
Infants below 2 years is 2000 to 5000 lipase units per 120 mL feeding; as the infant grows, adjust the dose should not exceed 2500 lipase units/kg while feeding (or 10,000 lipase units/kg daily)
In general, daily requirement dose is 500-4000 lipase units/gms of fat are necessary