RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
Background
GI foreign bodies are objects ingested and stuck in the digestive tract.
Foreign bodies in upper GI tract swallowed to causes common emergency department presentation in patients.
Foreign bodies in GI tract such as food, objects, medical devices require management based on nature, location, and patient’s condition.
Foreign objects in upper GI tract swallowed accidentally or purposefully.
Common Types of GI Foreign Bodies are:
Food-related objects:
E.g. Bones
Non-food objects:
E.g. Coins, buttons, batteries, pins
Sharp objects:
E.g. Glass, needles, toothpicks
Medical devices:
E.g. Endoscopy caps, stents, piece of feeding tubes
Groups including children, patients with psychiatric conditions, and individuals with esophageal or GI motility disorders have more chances of foreign body ingestion.
Major locations for foreign bodies as follow:
Esophagus
Stomach
Small intestine
Colon
Complications such as perforation, obstruction, infection, and hemorrhage are seen in patient.
Epidemiology
Unknown incidence of foreign body ingestions in all ages. Some study shows 1,671 magnet injuries cases yearly in USA.
Both race and nationality were not identified as factors in foreign body ingestion incidents. No distinctions based on race or nationality in children with swallowed foreign objects.
Men have higher incidence of accidentally swallowing foreign bodies than women.
75-85% of upper GI foreign body patients are children aged between 18 to 48 months.
Adults usually ingest food boluses, bones, fruit pits, dentures, or toothpicks. Prisoners and psychiatric patients may swallow bizarre objects.
Anatomy
GI tract may have foreign bodies, oropharynx well innervated for localizing them in patients.
Injuries to oropharynx mucosa cause foreign body sensation. Chronic foreign bodies or perforations lead to infections in throat tissues.
Objects over 2 cm may not pass the pylorus; those over 6 cm may get stuck at pylorus or duodenal sweep.
Sometimes bones or toothpicks can get stuck in the rectum to cause foreign body sensation.
Ingestion of small magnets at different times can cause bowel necrosis from adhesion.
Pathophysiology
GI tract may have foreign bodies, oropharynx well innervated for localizing them in patients.
Injuries to oropharynx mucosa cause foreign body sensation. Chronic foreign bodies or perforations lead to infections in throat tissues.
Objects over 2 cm may not pass the pylorus; those over 6 cm may get stuck at pylorus or duodenal sweep.
Sometimes bones or toothpicks can get stuck in the rectum to cause foreign body sensation.
Ingestion of small magnets at different times can cause bowel necrosis from adhesion.
Etiology
The causes of GI foreign bodies:
Accidental Ingestion
Intentional Ingestion
Swallowing Disorders
Poor Mastication and Dentition
Eating Habits
Medical Devices and Procedures
Genetics
Prognostic Factors
Clinical History
Clinical History:
Collect details on GI foreign body ingestion including symptoms, risk factors, and circumstances to understand clinical history of patient.
Physical Examination
Neck Examination
Respiratory Examination
Oropharyngeal Examination
Abdominal Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Severe symptoms are:
Acute chest or abdominal pain
Drooling or inability to swallow
Respiratory distress due to tracheal compression
Vomiting or bloody emesis
Sudden onset of severe pain
Moderate symptoms are:
Dysphagia
Odynophagia
Drooling and inability to manage oral secretions
Dysphagia or inability to swallow liquids or solids
Chest pain or pressure
Regurgitation of food or saliva
Nausea and vomiting
Epigastric pain or discomfort
Differential Diagnoses
Disk Battery Ingestion
Pediatric Foreign Body Ingestion
Mediastinitis in Emergency Medicine
Rectal Foreign Bodies
Retropharyngeal Abscess
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Airway-compromised patients may require immediate airway management. Seated position may be preferred for patients unable to handle secretions.
Button batteries is an emergency case they it causes esophageal wall necrosis within 2 hours from ingestion.
Cases of button batteries in stomach should keep under monitoring using radiographs and follow-up scans in 24 to 48 hours.
Direct and indirect oropharyngeal examination for foreign body sensation patients.
Consider CT scan and endoscopy for patients with suspected ingestion of nonopaque foreign bodies such as plastic objects or toothpicks.
Most healthy children with coins stuck in their esophagus pass them into the stomach afterward.
People who ingest drugs via body packing should be observed their whole-bowel irrigation helps to pass the packets.
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-non-pharmacological-approach-for-gastrointestinal-foreign-bodies
Continuous monitoring of young children necessary due to their tendency to ingest objects.
But only age-appropriate toys without small detachable parts.
Secure button batteries with tape or keep in tool-locked battery compartments.
Regular dental check-ups and proper denture fittings is important in elderly patients.
Eating soft or pureed foods reduces choking risk for those prone to swallowing large objects.
Swallowing therapy with a speech-language pathologist helps patients with dysphagia reduce risk of foreign body ingestion.
Proper awareness about GI foreign bodies should be provided and its related causes with management strategies.
Appointments with a physician and preventing recurrence of disorder is an ongoing life-long effort.
Use of Gastrointestinal agents
Glucagon:
It stimulates cAMP synthesis to increase hepatic glycogenolysis and gluconeogenesis in blood glucose levels.
Sodium bicarbonate, citric acid, and simethicone:
They neutralize acidity and relieves functional gastric bloating to improve peristaltic activity in the GI tract.
use-of-intervention-with-a-procedure-in-treating-gastrointestinal-foreign-bodies
The intervention for gastrointestinal (GI) foreign bodies involves procedures to remove the foreign body.
Key Interventions used for removal of GI Foreign Bodies are:
Endoscopy
Laparoscopy
Fluoroscopy-Assisted Removal
Bougie Dilation
use-of-phases-in-managing-gastrointestinal-foreign-bodies
In initial treatment phase, evaluation of type of foreign body, triage, physical examination and diagnostic test to confirm diagnosis.
Pharmacologic therapy is effective in the treatment phase as it includes use of gastrointestinal agents.
In supportive care and management phase, patients should receive required attention such as lifestyle modification and intervention therapies.
The regular follow-up visits with the physician are scheduled to check the improvement of patients along with treatment response.
Medication
Future Trends
GI foreign bodies are objects ingested and stuck in the digestive tract.
Foreign bodies in upper GI tract swallowed to causes common emergency department presentation in patients.
Foreign bodies in GI tract such as food, objects, medical devices require management based on nature, location, and patient’s condition.
Foreign objects in upper GI tract swallowed accidentally or purposefully.
Common Types of GI Foreign Bodies are:
Food-related objects:
E.g. Bones
Non-food objects:
E.g. Coins, buttons, batteries, pins
Sharp objects:
E.g. Glass, needles, toothpicks
Medical devices:
E.g. Endoscopy caps, stents, piece of feeding tubes
Groups including children, patients with psychiatric conditions, and individuals with esophageal or GI motility disorders have more chances of foreign body ingestion.
Major locations for foreign bodies as follow:
Esophagus
Stomach
Small intestine
Colon
Complications such as perforation, obstruction, infection, and hemorrhage are seen in patient.
Unknown incidence of foreign body ingestions in all ages. Some study shows 1,671 magnet injuries cases yearly in USA.
Both race and nationality were not identified as factors in foreign body ingestion incidents. No distinctions based on race or nationality in children with swallowed foreign objects.
Men have higher incidence of accidentally swallowing foreign bodies than women.
75-85% of upper GI foreign body patients are children aged between 18 to 48 months.
Adults usually ingest food boluses, bones, fruit pits, dentures, or toothpicks. Prisoners and psychiatric patients may swallow bizarre objects.
GI tract may have foreign bodies, oropharynx well innervated for localizing them in patients.
Injuries to oropharynx mucosa cause foreign body sensation. Chronic foreign bodies or perforations lead to infections in throat tissues.
Objects over 2 cm may not pass the pylorus; those over 6 cm may get stuck at pylorus or duodenal sweep.
Sometimes bones or toothpicks can get stuck in the rectum to cause foreign body sensation.
Ingestion of small magnets at different times can cause bowel necrosis from adhesion.
GI tract may have foreign bodies, oropharynx well innervated for localizing them in patients.
Injuries to oropharynx mucosa cause foreign body sensation. Chronic foreign bodies or perforations lead to infections in throat tissues.
Objects over 2 cm may not pass the pylorus; those over 6 cm may get stuck at pylorus or duodenal sweep.
Sometimes bones or toothpicks can get stuck in the rectum to cause foreign body sensation.
Ingestion of small magnets at different times can cause bowel necrosis from adhesion.
The causes of GI foreign bodies:
Accidental Ingestion
Intentional Ingestion
Swallowing Disorders
Poor Mastication and Dentition
Eating Habits
Medical Devices and Procedures
Clinical History:
Collect details on GI foreign body ingestion including symptoms, risk factors, and circumstances to understand clinical history of patient.
Neck Examination
Respiratory Examination
Oropharyngeal Examination
Abdominal Examination
Severe symptoms are:
Acute chest or abdominal pain
Drooling or inability to swallow
Respiratory distress due to tracheal compression
Vomiting or bloody emesis
Sudden onset of severe pain
Moderate symptoms are:
Dysphagia
Odynophagia
Drooling and inability to manage oral secretions
Dysphagia or inability to swallow liquids or solids
Chest pain or pressure
Regurgitation of food or saliva
Nausea and vomiting
Epigastric pain or discomfort
Disk Battery Ingestion
Pediatric Foreign Body Ingestion
Mediastinitis in Emergency Medicine
Rectal Foreign Bodies
Retropharyngeal Abscess
Airway-compromised patients may require immediate airway management. Seated position may be preferred for patients unable to handle secretions.
Button batteries is an emergency case they it causes esophageal wall necrosis within 2 hours from ingestion.
Cases of button batteries in stomach should keep under monitoring using radiographs and follow-up scans in 24 to 48 hours.
Direct and indirect oropharyngeal examination for foreign body sensation patients.
Consider CT scan and endoscopy for patients with suspected ingestion of nonopaque foreign bodies such as plastic objects or toothpicks.
Most healthy children with coins stuck in their esophagus pass them into the stomach afterward.
People who ingest drugs via body packing should be observed their whole-bowel irrigation helps to pass the packets.
Emergency Medicine
Continuous monitoring of young children necessary due to their tendency to ingest objects.
But only age-appropriate toys without small detachable parts.
Secure button batteries with tape or keep in tool-locked battery compartments.
Regular dental check-ups and proper denture fittings is important in elderly patients.
Eating soft or pureed foods reduces choking risk for those prone to swallowing large objects.
Swallowing therapy with a speech-language pathologist helps patients with dysphagia reduce risk of foreign body ingestion.
Proper awareness about GI foreign bodies should be provided and its related causes with management strategies.
Appointments with a physician and preventing recurrence of disorder is an ongoing life-long effort.
Emergency Medicine
Glucagon:
It stimulates cAMP synthesis to increase hepatic glycogenolysis and gluconeogenesis in blood glucose levels.
Sodium bicarbonate, citric acid, and simethicone:
They neutralize acidity and relieves functional gastric bloating to improve peristaltic activity in the GI tract.
Emergency Medicine
The intervention for gastrointestinal (GI) foreign bodies involves procedures to remove the foreign body.
Key Interventions used for removal of GI Foreign Bodies are:
Endoscopy
Laparoscopy
Fluoroscopy-Assisted Removal
Bougie Dilation
Emergency Medicine
In initial treatment phase, evaluation of type of foreign body, triage, physical examination and diagnostic test to confirm diagnosis.
Pharmacologic therapy is effective in the treatment phase as it includes use of gastrointestinal agents.
In supportive care and management phase, patients should receive required attention such as lifestyle modification and intervention therapies.
The regular follow-up visits with the physician are scheduled to check the improvement of patients along with treatment response.
GI foreign bodies are objects ingested and stuck in the digestive tract.
Foreign bodies in upper GI tract swallowed to causes common emergency department presentation in patients.
Foreign bodies in GI tract such as food, objects, medical devices require management based on nature, location, and patient’s condition.
Foreign objects in upper GI tract swallowed accidentally or purposefully.
Common Types of GI Foreign Bodies are:
Food-related objects:
E.g. Bones
Non-food objects:
E.g. Coins, buttons, batteries, pins
Sharp objects:
E.g. Glass, needles, toothpicks
Medical devices:
E.g. Endoscopy caps, stents, piece of feeding tubes
Groups including children, patients with psychiatric conditions, and individuals with esophageal or GI motility disorders have more chances of foreign body ingestion.
Major locations for foreign bodies as follow:
Esophagus
Stomach
Small intestine
Colon
Complications such as perforation, obstruction, infection, and hemorrhage are seen in patient.
Unknown incidence of foreign body ingestions in all ages. Some study shows 1,671 magnet injuries cases yearly in USA.
Both race and nationality were not identified as factors in foreign body ingestion incidents. No distinctions based on race or nationality in children with swallowed foreign objects.
Men have higher incidence of accidentally swallowing foreign bodies than women.
75-85% of upper GI foreign body patients are children aged between 18 to 48 months.
Adults usually ingest food boluses, bones, fruit pits, dentures, or toothpicks. Prisoners and psychiatric patients may swallow bizarre objects.
GI tract may have foreign bodies, oropharynx well innervated for localizing them in patients.
Injuries to oropharynx mucosa cause foreign body sensation. Chronic foreign bodies or perforations lead to infections in throat tissues.
Objects over 2 cm may not pass the pylorus; those over 6 cm may get stuck at pylorus or duodenal sweep.
Sometimes bones or toothpicks can get stuck in the rectum to cause foreign body sensation.
Ingestion of small magnets at different times can cause bowel necrosis from adhesion.
GI tract may have foreign bodies, oropharynx well innervated for localizing them in patients.
Injuries to oropharynx mucosa cause foreign body sensation. Chronic foreign bodies or perforations lead to infections in throat tissues.
Objects over 2 cm may not pass the pylorus; those over 6 cm may get stuck at pylorus or duodenal sweep.
Sometimes bones or toothpicks can get stuck in the rectum to cause foreign body sensation.
Ingestion of small magnets at different times can cause bowel necrosis from adhesion.
The causes of GI foreign bodies:
Accidental Ingestion
Intentional Ingestion
Swallowing Disorders
Poor Mastication and Dentition
Eating Habits
Medical Devices and Procedures
Clinical History:
Collect details on GI foreign body ingestion including symptoms, risk factors, and circumstances to understand clinical history of patient.
Neck Examination
Respiratory Examination
Oropharyngeal Examination
Abdominal Examination
Severe symptoms are:
Acute chest or abdominal pain
Drooling or inability to swallow
Respiratory distress due to tracheal compression
Vomiting or bloody emesis
Sudden onset of severe pain
Moderate symptoms are:
Dysphagia
Odynophagia
Drooling and inability to manage oral secretions
Dysphagia or inability to swallow liquids or solids
Chest pain or pressure
Regurgitation of food or saliva
Nausea and vomiting
Epigastric pain or discomfort
Disk Battery Ingestion
Pediatric Foreign Body Ingestion
Mediastinitis in Emergency Medicine
Rectal Foreign Bodies
Retropharyngeal Abscess
Airway-compromised patients may require immediate airway management. Seated position may be preferred for patients unable to handle secretions.
Button batteries is an emergency case they it causes esophageal wall necrosis within 2 hours from ingestion.
Cases of button batteries in stomach should keep under monitoring using radiographs and follow-up scans in 24 to 48 hours.
Direct and indirect oropharyngeal examination for foreign body sensation patients.
Consider CT scan and endoscopy for patients with suspected ingestion of nonopaque foreign bodies such as plastic objects or toothpicks.
Most healthy children with coins stuck in their esophagus pass them into the stomach afterward.
People who ingest drugs via body packing should be observed their whole-bowel irrigation helps to pass the packets.
Emergency Medicine
Continuous monitoring of young children necessary due to their tendency to ingest objects.
But only age-appropriate toys without small detachable parts.
Secure button batteries with tape or keep in tool-locked battery compartments.
Regular dental check-ups and proper denture fittings is important in elderly patients.
Eating soft or pureed foods reduces choking risk for those prone to swallowing large objects.
Swallowing therapy with a speech-language pathologist helps patients with dysphagia reduce risk of foreign body ingestion.
Proper awareness about GI foreign bodies should be provided and its related causes with management strategies.
Appointments with a physician and preventing recurrence of disorder is an ongoing life-long effort.
Emergency Medicine
Glucagon:
It stimulates cAMP synthesis to increase hepatic glycogenolysis and gluconeogenesis in blood glucose levels.
Sodium bicarbonate, citric acid, and simethicone:
They neutralize acidity and relieves functional gastric bloating to improve peristaltic activity in the GI tract.
Emergency Medicine
The intervention for gastrointestinal (GI) foreign bodies involves procedures to remove the foreign body.
Key Interventions used for removal of GI Foreign Bodies are:
Endoscopy
Laparoscopy
Fluoroscopy-Assisted Removal
Bougie Dilation
Emergency Medicine
In initial treatment phase, evaluation of type of foreign body, triage, physical examination and diagnostic test to confirm diagnosis.
Pharmacologic therapy is effective in the treatment phase as it includes use of gastrointestinal agents.
In supportive care and management phase, patients should receive required attention such as lifestyle modification and intervention therapies.
The regular follow-up visits with the physician are scheduled to check the improvement of patients along with treatment response.

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