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December 15, 2025
Background
Trichotillomania, a clinical term for hair-pulling disorder, is a mental illness marked by persistent, compulsive urges to remove hair from the eyebrows, lashes on the eyes, or other regions of the body, which causes visible hair loss. This falls under the heading of Obsessive and Related Disorders in the DSM-5 (the Diagnostic and Statistical Handbook of Mental Disorders, Fifth Edition).Â
Trichotillomania affects individuals of all ages and genders, although it typically begins in adolescence or early adulthood. Underreporting and misinterpretation make it difficult to pinpoint the precise prevalence, however it is thought to impact 1% to 2% of the population. Significant distress and functional impairment in social, vocational, and other domains can result from trichotillomania.Â
It may result in noticeable hair loss, bald patches, and skin damage. Individuals may also experience negative emotions, such as depression, anxiety, or low self-esteem, related to their hair-pulling behaviors.Â
Epidemiology
Prevalence:Â
Comorbidity and Associated Factors:Â
Anatomy
Pathophysiology
Genetic Factors:Â
Neurobiological Factors:Â
Psychological Factors:Â
Cognitive Factors:Â
Environmental Factors:Â
Etiology
Genetic Factors:Â
Neurobiological Factors:Â
Psychological Factors:Â
Behavioral Factors:Â
Environmental Factors:Â
Genetics
Prognostic Factors
Clinical History
Age Group:Â
Children and Adolescents:Â
Adults:Â
Physical Examination
Hair Loss Patterns:Â
Bald Patches:Â
Hair Regrowth:Â
Skin Examination:Â
Examination of Eyebrows and Eyelashes:Â
Scalp Examination:Â
Age group
Associated comorbidity
Anxiety Disorders:Â
Depression:Â
Obsessive-Compulsive Disorder (OCD):Â
Body-Focused Repetitive Behaviors (BFRBs):Â
Associated activity
Acuity of presentation
Chronic Presentation:Â
Episodic or Acute Presentation:Â
Cyclic Patterns:Â
Differential Diagnoses
Alopecia Areata:Â
Tinea Capitis:Â
Telogen Effluvium:Â
Body-Focused Repetitive Behaviors (BFRBs):Â
Obsessive-Compulsive Disorder (OCD):Â
Psychogenic Excoriation (Dermatillomania):Â
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Behavioral Therapies:Â
Cognitive-Behavioral Therapy (CBT): For the treatment of trichotillomania, cognitive behavioral therapy is seen to be the best option. Its main goal is to pinpoint and alter the ideas and actions that lead to hair pulling. Components of CBT for Trichotillomania may include:Â
Pharmacotherapy:Â
Mindfulness-Based Approaches:Â
Support Groups:Â
Psychoeducation:Â
Family Therapy:Â
Dermatological Support:Â
Occupational Therapy:Â
Relapse Prevention:Â
Gradual Exposure and Response Prevention (ERP):Â
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-a-non-pharmacological-approach-for-treating-hair-pulling-disorder
Cognitive-Behavioral Therapy (CBT):Â
Comprehensive Behavioral Intervention for Tics (CBIT):Â
Mindfulness-Based Approaches:Â
Acceptance and Commitment Therapy (ACT):Â
Psychoeducation:Â
Exposure and Response Prevention (ERP):Â
Support Groups:Â
Family Therapy:Â
Hypnotherapy:Â
Occupational Therapy:Â
Use of Selective Serotonin Reuptake Inhibitors in the treatment of Hair-Pulling Disorder
They are commonly used in the treatment of Hair-Pulling Disorder (Trichotillomania). SSRIs are a class of antidepressant medications that primarily affect the levels of serotonin, a neurotransmitter, in the brain. While their primary indication is for depressive and anxiety disorders, SSRIs have shown efficacy in addressing impulse control disorders, including Trichotillomania. Inhibiting serotonin reuptake results in elevated serotonin levels in the synaptic cleft, which is how they act. Serotonin is involved in regulating emotions, mood and behavioral patterns. The modulation of serotonin levels is believed to have an impact on impulse control and obsessive-compulsive behaviors.Â
Use of Antioxidants in the treatment of Hair-Pulling Disorder
Antioxidants, including N-acetylcysteine (NAC), have been explored in the treatment of Hair-Pulling Disorder (Trichotillomania) due to their potential to address oxidative stress and modulate neurotransmitter systems. The antioxidant properties of NAC may contribute to its therapeutic effects by neutralizing free radicals. Antioxidants may help restore balance and reduce oxidative damage in the brain.Â
N-acetylcysteine: It has been explored as a potential treatment for Hair-Pulling Disorder (Trichotillomania). Cysteine (a precursor amino acid) is produced by the supplement and drug NAC. It has antioxidant properties and is believed to modulate glutamate levels in the brain, which may contribute to its therapeutic effects. Glutamate is a neurotransmitter in the brain associated with excitatory signaling. Dysregulation of glutamate levels has been implicated in certain psychiatric conditions, including impulse control disorders.Â
The dosage of NAC used in the treatment of Trichotillomania can vary. Typically, doses ranging from 1200 mg to 3600 mg per day have been studied.Â
Use of Tricyclic Antidepressants’ in the treatment of Hair-Pulling Disorder
Tricyclic antidepressants (TCAs) have been considered in the treatment of Hair-Pulling Disorder (Trichotillomania). However, their use is not as common as other medications like selective serotonin reuptake inhibitors (SSRIs) or N-acetylcysteine (NAC). A class of antidepressant drugs known as TCAs modifies the brain’s levels of neurotransmitters like norepinephrine and serotonin.TCAs mainly improve neurotransmission by preventing serotonin and norepinephrine from being reabsorbed into the brain. The modulation of these neurotransmitters is believed to influence mood and potentially impact impulse control behaviors.Â
Clomipramine:Â
Nortriptyline:Â
use-of-intervention-with-a-procedure-in-treating-hair-pulling-disorder
Scalp Injections:Â
Hair Transplantation:Â
Scalp Micropigmentation (SMP):Â
Behavioral Modification Techniques:Â
Electroconvulsive Therapy (ECT):Â
use-of-phases-in-managing-hair-pulling-disorder
Assessment Phase:Â
Psychoeducation Phase:Â
Behavioral Strategies Phase:Â
Cognitive Restructuring Phase:Â
Maintenance and Relapse Prevention Phase:Â
Follow-Up and Monitoring Phase:Â
Medication
Future Trends
References
Trichotillomania, a clinical term for hair-pulling disorder, is a mental illness marked by persistent, compulsive urges to remove hair from the eyebrows, lashes on the eyes, or other regions of the body, which causes visible hair loss. This falls under the heading of Obsessive and Related Disorders in the DSM-5 (the Diagnostic and Statistical Handbook of Mental Disorders, Fifth Edition).Â
Trichotillomania affects individuals of all ages and genders, although it typically begins in adolescence or early adulthood. Underreporting and misinterpretation make it difficult to pinpoint the precise prevalence, however it is thought to impact 1% to 2% of the population. Significant distress and functional impairment in social, vocational, and other domains can result from trichotillomania.Â
It may result in noticeable hair loss, bald patches, and skin damage. Individuals may also experience negative emotions, such as depression, anxiety, or low self-esteem, related to their hair-pulling behaviors.Â
Prevalence:Â
Comorbidity and Associated Factors:Â
Genetic Factors:Â
Neurobiological Factors:Â
Psychological Factors:Â
Cognitive Factors:Â
Environmental Factors:Â
Genetic Factors:Â
Neurobiological Factors:Â
Psychological Factors:Â
Behavioral Factors:Â
Environmental Factors:Â
Age Group:Â
Children and Adolescents:Â
Adults:Â
Hair Loss Patterns:Â
Bald Patches:Â
Hair Regrowth:Â
Skin Examination:Â
Examination of Eyebrows and Eyelashes:Â
Scalp Examination:Â
Anxiety Disorders:Â
Depression:Â
Obsessive-Compulsive Disorder (OCD):Â
Body-Focused Repetitive Behaviors (BFRBs):Â
Chronic Presentation:Â
Episodic or Acute Presentation:Â
Cyclic Patterns:Â
Alopecia Areata:Â
Tinea Capitis:Â
Telogen Effluvium:Â
Body-Focused Repetitive Behaviors (BFRBs):Â
Obsessive-Compulsive Disorder (OCD):Â
Psychogenic Excoriation (Dermatillomania):Â
Behavioral Therapies:Â
Cognitive-Behavioral Therapy (CBT): For the treatment of trichotillomania, cognitive behavioral therapy is seen to be the best option. Its main goal is to pinpoint and alter the ideas and actions that lead to hair pulling. Components of CBT for Trichotillomania may include:Â
Pharmacotherapy:Â
Mindfulness-Based Approaches:Â
Support Groups:Â
Psychoeducation:Â
Family Therapy:Â
Dermatological Support:Â
Occupational Therapy:Â
Relapse Prevention:Â
Gradual Exposure and Response Prevention (ERP):Â
Family Medicine
Cognitive-Behavioral Therapy (CBT):Â
Comprehensive Behavioral Intervention for Tics (CBIT):Â
Mindfulness-Based Approaches:Â
Acceptance and Commitment Therapy (ACT):Â
Psychoeducation:Â
Exposure and Response Prevention (ERP):Â
Support Groups:Â
Family Therapy:Â
Hypnotherapy:Â
Occupational Therapy:Â
Psychiatry/Mental Health
They are commonly used in the treatment of Hair-Pulling Disorder (Trichotillomania). SSRIs are a class of antidepressant medications that primarily affect the levels of serotonin, a neurotransmitter, in the brain. While their primary indication is for depressive and anxiety disorders, SSRIs have shown efficacy in addressing impulse control disorders, including Trichotillomania. Inhibiting serotonin reuptake results in elevated serotonin levels in the synaptic cleft, which is how they act. Serotonin is involved in regulating emotions, mood and behavioral patterns. The modulation of serotonin levels is believed to have an impact on impulse control and obsessive-compulsive behaviors.Â
Neurology
Psychiatry/Mental Health
Antioxidants, including N-acetylcysteine (NAC), have been explored in the treatment of Hair-Pulling Disorder (Trichotillomania) due to their potential to address oxidative stress and modulate neurotransmitter systems. The antioxidant properties of NAC may contribute to its therapeutic effects by neutralizing free radicals. Antioxidants may help restore balance and reduce oxidative damage in the brain.Â
N-acetylcysteine: It has been explored as a potential treatment for Hair-Pulling Disorder (Trichotillomania). Cysteine (a precursor amino acid) is produced by the supplement and drug NAC. It has antioxidant properties and is believed to modulate glutamate levels in the brain, which may contribute to its therapeutic effects. Glutamate is a neurotransmitter in the brain associated with excitatory signaling. Dysregulation of glutamate levels has been implicated in certain psychiatric conditions, including impulse control disorders.Â
The dosage of NAC used in the treatment of Trichotillomania can vary. Typically, doses ranging from 1200 mg to 3600 mg per day have been studied.Â
Neurology
Psychiatry/Mental Health
Tricyclic antidepressants (TCAs) have been considered in the treatment of Hair-Pulling Disorder (Trichotillomania). However, their use is not as common as other medications like selective serotonin reuptake inhibitors (SSRIs) or N-acetylcysteine (NAC). A class of antidepressant drugs known as TCAs modifies the brain’s levels of neurotransmitters like norepinephrine and serotonin.TCAs mainly improve neurotransmission by preventing serotonin and norepinephrine from being reabsorbed into the brain. The modulation of these neurotransmitters is believed to influence mood and potentially impact impulse control behaviors.Â
Clomipramine:Â
Nortriptyline:Â
Family Medicine
Scalp Injections:Â
Hair Transplantation:Â
Scalp Micropigmentation (SMP):Â
Behavioral Modification Techniques:Â
Electroconvulsive Therapy (ECT):Â
Family Medicine
Assessment Phase:Â
Psychoeducation Phase:Â
Behavioral Strategies Phase:Â
Cognitive Restructuring Phase:Â
Maintenance and Relapse Prevention Phase:Â
Follow-Up and Monitoring Phase:Â
Trichotillomania, a clinical term for hair-pulling disorder, is a mental illness marked by persistent, compulsive urges to remove hair from the eyebrows, lashes on the eyes, or other regions of the body, which causes visible hair loss. This falls under the heading of Obsessive and Related Disorders in the DSM-5 (the Diagnostic and Statistical Handbook of Mental Disorders, Fifth Edition).Â
Trichotillomania affects individuals of all ages and genders, although it typically begins in adolescence or early adulthood. Underreporting and misinterpretation make it difficult to pinpoint the precise prevalence, however it is thought to impact 1% to 2% of the population. Significant distress and functional impairment in social, vocational, and other domains can result from trichotillomania.Â
It may result in noticeable hair loss, bald patches, and skin damage. Individuals may also experience negative emotions, such as depression, anxiety, or low self-esteem, related to their hair-pulling behaviors.Â
Prevalence:Â
Comorbidity and Associated Factors:Â
Genetic Factors:Â
Neurobiological Factors:Â
Psychological Factors:Â
Cognitive Factors:Â
Environmental Factors:Â
Genetic Factors:Â
Neurobiological Factors:Â
Psychological Factors:Â
Behavioral Factors:Â
Environmental Factors:Â
Age Group:Â
Children and Adolescents:Â
Adults:Â
Hair Loss Patterns:Â
Bald Patches:Â
Hair Regrowth:Â
Skin Examination:Â
Examination of Eyebrows and Eyelashes:Â
Scalp Examination:Â
Anxiety Disorders:Â
Depression:Â
Obsessive-Compulsive Disorder (OCD):Â
Body-Focused Repetitive Behaviors (BFRBs):Â
Chronic Presentation:Â
Episodic or Acute Presentation:Â
Cyclic Patterns:Â
Alopecia Areata:Â
Tinea Capitis:Â
Telogen Effluvium:Â
Body-Focused Repetitive Behaviors (BFRBs):Â
Obsessive-Compulsive Disorder (OCD):Â
Psychogenic Excoriation (Dermatillomania):Â
Behavioral Therapies:Â
Cognitive-Behavioral Therapy (CBT): For the treatment of trichotillomania, cognitive behavioral therapy is seen to be the best option. Its main goal is to pinpoint and alter the ideas and actions that lead to hair pulling. Components of CBT for Trichotillomania may include:Â
Pharmacotherapy:Â
Mindfulness-Based Approaches:Â
Support Groups:Â
Psychoeducation:Â
Family Therapy:Â
Dermatological Support:Â
Occupational Therapy:Â
Relapse Prevention:Â
Gradual Exposure and Response Prevention (ERP):Â
Family Medicine
Cognitive-Behavioral Therapy (CBT):Â
Comprehensive Behavioral Intervention for Tics (CBIT):Â
Mindfulness-Based Approaches:Â
Acceptance and Commitment Therapy (ACT):Â
Psychoeducation:Â
Exposure and Response Prevention (ERP):Â
Support Groups:Â
Family Therapy:Â
Hypnotherapy:Â
Occupational Therapy:Â
Psychiatry/Mental Health
They are commonly used in the treatment of Hair-Pulling Disorder (Trichotillomania). SSRIs are a class of antidepressant medications that primarily affect the levels of serotonin, a neurotransmitter, in the brain. While their primary indication is for depressive and anxiety disorders, SSRIs have shown efficacy in addressing impulse control disorders, including Trichotillomania. Inhibiting serotonin reuptake results in elevated serotonin levels in the synaptic cleft, which is how they act. Serotonin is involved in regulating emotions, mood and behavioral patterns. The modulation of serotonin levels is believed to have an impact on impulse control and obsessive-compulsive behaviors.Â
Neurology
Psychiatry/Mental Health
Antioxidants, including N-acetylcysteine (NAC), have been explored in the treatment of Hair-Pulling Disorder (Trichotillomania) due to their potential to address oxidative stress and modulate neurotransmitter systems. The antioxidant properties of NAC may contribute to its therapeutic effects by neutralizing free radicals. Antioxidants may help restore balance and reduce oxidative damage in the brain.Â
N-acetylcysteine: It has been explored as a potential treatment for Hair-Pulling Disorder (Trichotillomania). Cysteine (a precursor amino acid) is produced by the supplement and drug NAC. It has antioxidant properties and is believed to modulate glutamate levels in the brain, which may contribute to its therapeutic effects. Glutamate is a neurotransmitter in the brain associated with excitatory signaling. Dysregulation of glutamate levels has been implicated in certain psychiatric conditions, including impulse control disorders.Â
The dosage of NAC used in the treatment of Trichotillomania can vary. Typically, doses ranging from 1200 mg to 3600 mg per day have been studied.Â
Neurology
Psychiatry/Mental Health
Tricyclic antidepressants (TCAs) have been considered in the treatment of Hair-Pulling Disorder (Trichotillomania). However, their use is not as common as other medications like selective serotonin reuptake inhibitors (SSRIs) or N-acetylcysteine (NAC). A class of antidepressant drugs known as TCAs modifies the brain’s levels of neurotransmitters like norepinephrine and serotonin.TCAs mainly improve neurotransmission by preventing serotonin and norepinephrine from being reabsorbed into the brain. The modulation of these neurotransmitters is believed to influence mood and potentially impact impulse control behaviors.Â
Clomipramine:Â
Nortriptyline:Â
Family Medicine
Scalp Injections:Â
Hair Transplantation:Â
Scalp Micropigmentation (SMP):Â
Behavioral Modification Techniques:Â
Electroconvulsive Therapy (ECT):Â
Family Medicine
Assessment Phase:Â
Psychoeducation Phase:Â
Behavioral Strategies Phase:Â
Cognitive Restructuring Phase:Â
Maintenance and Relapse Prevention Phase:Â
Follow-Up and Monitoring Phase:Â

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