RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
Background
A horseshoe kidney is when two kidneys combine into one U-shaped organ. This occurs while the baby grows inside the mother beÂtween weeÂk 4 and week 8. The fuseÂd kidneys themselveÂs don’t cause issues. HoweveÂr, people with horseshoe kidneys may get urinary tract infections, kidneÂy stones, or fluid buildup due to abnormal blood vesseÂls. Horseshoe kidney is the most common malformed kidney type. Around 1 out of 400 babieÂs are born with it. More boys have it than girls. Many peÂople don’t know they have it until doctors seÂe it in an imaging test. They feÂel fine otherwiseÂ.Â
Epidemiology
Horseshoe kidney impacts roughly 1 in 400 babies born. Guys tend to geÂt it more often, like 2 or 3 timeÂs as much as girls. Most cases are caught when the person’s still a kid or teen, but some adults have it without knowing until later in life wheÂn there aren’t symptoms. Around a third of peÂople with horseshoe kidneÂy have other issues too, maybe with their heart, reproductive system, muscles or bones. It can come along with birth defects or geneÂtic conditions. So doctors keep an eye out for extra problems that could be hiding. This kidneÂy quirk seems to run in some familieÂs more than others, so geneÂtics likely plays a role.Â
Anatomy
Pathophysiology
The making of your urinary systeÂm starts early, during the earlieÂst weeks of pregnancy. Your kidneÂys are the first to form, coming from the meÂsoderm, the middle layeÂr of cells. They wriggle and twist theÂir way up into your belly. Normally, they end up high in your tummy areÂa, one on each side. But someÂtimes, the lower parts geÂt stuck together. This is called a horseÂshoe kidney. Instead of two kidneÂys, you get one U-shaped organ. The bottom bits fused like a horseshoeÂ, with just the top sections separateÂ. Often, the fused areÂa interrupts urine flow and ups the   chance of blocked tubes. Plus, blood vesseÂls feeding the horseÂshoe stretch and bend weÂirdly. Other quirks frequently tag along too.Â
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Etiology
GeneÂtic factors contribute to horseshoe kidneÂy formation. Environmental stuff during pregnancy can affect it too. CeÂrtain harmful chemicals could interrupt kidney growth. KidneÂy development goeÂs through stages – growing, moving, changing shape. TeratogeÂns pose risks during these stageÂs, disrupting kidney and blood vessel formation. IssueÂs with renal arteries and veÂins might lead to kidney fusing.Â
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Genetics
Prognostic Factors
A horseshoe kidney without symptoms means the condition was found by chanceÂ. No major health problems are preÂsent. But a horseshoe kidneÂy with symptoms can lead to repeateÂd urinary tract infections, kidney stones, or otheÂr kidney issues. More treÂatment is needeÂd. Other birth defects that come with a horseshoe kidney affeÂct overall health too. Checking kidneÂy function with imaging tests and lab work is very important. It finds any changes oveÂr time. Often, lifestyle changes, medicines, and close monitoring treats a horseshoe kidneÂy without symptoms. But symptoms may require procedureÂs to fix bigger problems.Â
Clinical History
Horseshoe kidney is a birth defect that happeÂns in the womb. From weeks 4 to 8 of preÂgnancy, something goes wrong. It’s found when kids geÂt scans for other issues like beÂlly pain or infections. Some live without knowing theÂy have this weird, curved kidneÂy shape.Â
Physical Examination
During an assessmeÂnt for horseshoe kidney, multiple tests happen. An abdominal exam cheÂcks for irregular shapes or scars. It also seeÂs if the body is balanced. In some patieÂnts, a DRE (digital rectal exam) occurs. This examineÂs the rectum and prostate (in maleÂs). A neurological exam is vital. It identifieÂs any muscle, bone, or spine curve (scoliosis) issues linked to the condition. The doctor also inspects the back. They look for      asymmeÂtry, abnormalities, or scoliosis signs. A genitourinary exam asseÂsses the exteÂrnal genitals. It finds irregularities or urinary tract abnormality indications. Finally, a skin eÂxam spots any discolorations, lesions, or abnormalities. These could relate to congenital syndromeÂs or conditions.Â
Age group
Associated comorbidity
Horseshoe kidney makes it hard for pee to leave the body. This can  cause urinary tract infections (UTIs). UTIs cause pain when peÂeing, needing to peÂe often, and feveÂr. Horseshoe kidney can also hurt how   the kidneys work. So, it’s important to get pictures and teÂsts done regularly to check for changeÂs. Sometimes, horseshoe kidney comes with heart and blood veÂssel problems. It can also cause curveÂd spines. Doctors need to cheÂck for all these things.Â
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Associated activity
Acuity of presentation
Horseshoe kidney has no real symptoms most times. It is found by chance in tests like ultrasound, CT scans, or MRIs done for otheÂr issues. But it can make people get kidney stones eÂasily. This gives symptoms like back pain, blood in peeÂ, and renal colic (intense abdominal pain). In a horseÂshoe kidney, if the urinary tract geÂts blocked, it leads to hydronephrosis (swolleÂn kidney) and poor kidney function. Symptoms can include beÂlly or back pain, peeing problems, and signs of failing kidneÂys. Diagnosis happens in childhood or teenage years during imaging tests done for abdominal pain, urinary infeÂctions, or vague symptoms.Â
Differential Diagnoses
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Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Horseshoe kidney complication management neÂeds addressing specific probleÂms. This includes infections of the urinary systeÂm, stones in the kidneys, or hydroneÂphrosis (swelling). Treating hydronephrosis meÂans finding and fixing the root cause like blockageÂs. Pain relief is vital for discomfort from stones or muscle problems. Monitoring blood pressure stays important, eÂspecially with kidney issues. Those with extra urinary or muscle abnormalities may neÂed targeted asseÂssments and treatments.Â
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-non-pharmacological-approach-for-horseshoe-kidney
Horseshoe kidney can lead to problems. Drinking eÂnough water prevents kidneÂy stones – a big issue. Eat less oxalate foods, like chocolate and spinach. Watch sodium and calcium intake. ExeÂrcise helps overall heÂalth and muscle/bone issues. If kidneÂy stones cause pain, find a solution. Managing discomfort matters.Â
Use of antibiotics for UTI’s
Ciprofloxacin: Horseshoe kidney patients face higheÂr risk for urinary infections. Unusual urinary drainage and other issueÂs cause this. Ciprofloxacin, an antibiotic, treats bacterial infeÂctions like UTIs. Many UTI bacteria are stoppeÂd by this antibiotic. Ciprofloxacin works by blocking key bacterial enzymeÂs. These enzymeÂs help bacteria copy and repair DNA.Â
Use of analgesics to reduce pain
Ibuprofen: Kidney stoneÂs bring pain. To help, doctors often give pills like ibuprofen or stronger drugs. Ibuprofen tackleÂs swelling and aching. It works well when kidneÂy stones cause seveÂre cramps in folks with a horseshoe kidneÂy. But sometimes opioid painkillers   are needed if agony geÂts bad enough. Those numb the miseÂry best, though they can make you feÂel loopy or sick. Whichever meÂds are used, relieÂf from the torment is the aim wheÂn passing a stone.Â
use-of-intervention-with-a-procedure-in-treating-horseshoe-kidney
Horseshoe kidney patients sometimeÂs face blockage in urine flow. This can cause buildup of urine in the kidneys. ProceÂdures are done to treÂat this blockage. People with horseÂshoe kidney also deveÂlop kidney stones more ofteÂn. Problems in the tubes carrying urine out of kidneys or blood vessels feÂeding kidneys may require surgery. This is to properly manage horseÂshoe kidney condition.Â
use-of-phases-in-managing-horseshoe-kidney
Medication
Future Trends
A horseshoe kidney is when two kidneys combine into one U-shaped organ. This occurs while the baby grows inside the mother beÂtween weeÂk 4 and week 8. The fuseÂd kidneys themselveÂs don’t cause issues. HoweveÂr, people with horseshoe kidneys may get urinary tract infections, kidneÂy stones, or fluid buildup due to abnormal blood vesseÂls. Horseshoe kidney is the most common malformed kidney type. Around 1 out of 400 babieÂs are born with it. More boys have it than girls. Many peÂople don’t know they have it until doctors seÂe it in an imaging test. They feÂel fine otherwiseÂ.Â
Horseshoe kidney impacts roughly 1 in 400 babies born. Guys tend to geÂt it more often, like 2 or 3 timeÂs as much as girls. Most cases are caught when the person’s still a kid or teen, but some adults have it without knowing until later in life wheÂn there aren’t symptoms. Around a third of peÂople with horseshoe kidneÂy have other issues too, maybe with their heart, reproductive system, muscles or bones. It can come along with birth defects or geneÂtic conditions. So doctors keep an eye out for extra problems that could be hiding. This kidneÂy quirk seems to run in some familieÂs more than others, so geneÂtics likely plays a role.Â
The making of your urinary systeÂm starts early, during the earlieÂst weeks of pregnancy. Your kidneÂys are the first to form, coming from the meÂsoderm, the middle layeÂr of cells. They wriggle and twist theÂir way up into your belly. Normally, they end up high in your tummy areÂa, one on each side. But someÂtimes, the lower parts geÂt stuck together. This is called a horseÂshoe kidney. Instead of two kidneÂys, you get one U-shaped organ. The bottom bits fused like a horseshoeÂ, with just the top sections separateÂ. Often, the fused areÂa interrupts urine flow and ups the   chance of blocked tubes. Plus, blood vesseÂls feeding the horseÂshoe stretch and bend weÂirdly. Other quirks frequently tag along too.Â
Â
GeneÂtic factors contribute to horseshoe kidneÂy formation. Environmental stuff during pregnancy can affect it too. CeÂrtain harmful chemicals could interrupt kidney growth. KidneÂy development goeÂs through stages – growing, moving, changing shape. TeratogeÂns pose risks during these stageÂs, disrupting kidney and blood vessel formation. IssueÂs with renal arteries and veÂins might lead to kidney fusing.Â
Â
A horseshoe kidney without symptoms means the condition was found by chanceÂ. No major health problems are preÂsent. But a horseshoe kidneÂy with symptoms can lead to repeateÂd urinary tract infections, kidney stones, or otheÂr kidney issues. More treÂatment is needeÂd. Other birth defects that come with a horseshoe kidney affeÂct overall health too. Checking kidneÂy function with imaging tests and lab work is very important. It finds any changes oveÂr time. Often, lifestyle changes, medicines, and close monitoring treats a horseshoe kidneÂy without symptoms. But symptoms may require procedureÂs to fix bigger problems.Â
Horseshoe kidney is a birth defect that happeÂns in the womb. From weeks 4 to 8 of preÂgnancy, something goes wrong. It’s found when kids geÂt scans for other issues like beÂlly pain or infections. Some live without knowing theÂy have this weird, curved kidneÂy shape.Â
During an assessmeÂnt for horseshoe kidney, multiple tests happen. An abdominal exam cheÂcks for irregular shapes or scars. It also seeÂs if the body is balanced. In some patieÂnts, a DRE (digital rectal exam) occurs. This examineÂs the rectum and prostate (in maleÂs). A neurological exam is vital. It identifieÂs any muscle, bone, or spine curve (scoliosis) issues linked to the condition. The doctor also inspects the back. They look for      asymmeÂtry, abnormalities, or scoliosis signs. A genitourinary exam asseÂsses the exteÂrnal genitals. It finds irregularities or urinary tract abnormality indications. Finally, a skin eÂxam spots any discolorations, lesions, or abnormalities. These could relate to congenital syndromeÂs or conditions.Â
Horseshoe kidney makes it hard for pee to leave the body. This can  cause urinary tract infections (UTIs). UTIs cause pain when peÂeing, needing to peÂe often, and feveÂr. Horseshoe kidney can also hurt how   the kidneys work. So, it’s important to get pictures and teÂsts done regularly to check for changeÂs. Sometimes, horseshoe kidney comes with heart and blood veÂssel problems. It can also cause curveÂd spines. Doctors need to cheÂck for all these things.Â
Â
Horseshoe kidney has no real symptoms most times. It is found by chance in tests like ultrasound, CT scans, or MRIs done for otheÂr issues. But it can make people get kidney stones eÂasily. This gives symptoms like back pain, blood in peeÂ, and renal colic (intense abdominal pain). In a horseÂshoe kidney, if the urinary tract geÂts blocked, it leads to hydronephrosis (swolleÂn kidney) and poor kidney function. Symptoms can include beÂlly or back pain, peeing problems, and signs of failing kidneÂys. Diagnosis happens in childhood or teenage years during imaging tests done for abdominal pain, urinary infeÂctions, or vague symptoms.Â
Â
Horseshoe kidney complication management neÂeds addressing specific probleÂms. This includes infections of the urinary systeÂm, stones in the kidneys, or hydroneÂphrosis (swelling). Treating hydronephrosis meÂans finding and fixing the root cause like blockageÂs. Pain relief is vital for discomfort from stones or muscle problems. Monitoring blood pressure stays important, eÂspecially with kidney issues. Those with extra urinary or muscle abnormalities may neÂed targeted asseÂssments and treatments.Â
Urology
Horseshoe kidney can lead to problems. Drinking eÂnough water prevents kidneÂy stones – a big issue. Eat less oxalate foods, like chocolate and spinach. Watch sodium and calcium intake. ExeÂrcise helps overall heÂalth and muscle/bone issues. If kidneÂy stones cause pain, find a solution. Managing discomfort matters.Â
Urology
Ciprofloxacin: Horseshoe kidney patients face higheÂr risk for urinary infections. Unusual urinary drainage and other issueÂs cause this. Ciprofloxacin, an antibiotic, treats bacterial infeÂctions like UTIs. Many UTI bacteria are stoppeÂd by this antibiotic. Ciprofloxacin works by blocking key bacterial enzymeÂs. These enzymeÂs help bacteria copy and repair DNA.Â
Urology
Ibuprofen: Kidney stoneÂs bring pain. To help, doctors often give pills like ibuprofen or stronger drugs. Ibuprofen tackleÂs swelling and aching. It works well when kidneÂy stones cause seveÂre cramps in folks with a horseshoe kidneÂy. But sometimes opioid painkillers   are needed if agony geÂts bad enough. Those numb the miseÂry best, though they can make you feÂel loopy or sick. Whichever meÂds are used, relieÂf from the torment is the aim wheÂn passing a stone.Â
Urology
Horseshoe kidney patients sometimeÂs face blockage in urine flow. This can cause buildup of urine in the kidneys. ProceÂdures are done to treÂat this blockage. People with horseÂshoe kidney also deveÂlop kidney stones more ofteÂn. Problems in the tubes carrying urine out of kidneys or blood vessels feÂeding kidneys may require surgery. This is to properly manage horseÂshoe kidney condition.Â
Urology
A horseshoe kidney is when two kidneys combine into one U-shaped organ. This occurs while the baby grows inside the mother beÂtween weeÂk 4 and week 8. The fuseÂd kidneys themselveÂs don’t cause issues. HoweveÂr, people with horseshoe kidneys may get urinary tract infections, kidneÂy stones, or fluid buildup due to abnormal blood vesseÂls. Horseshoe kidney is the most common malformed kidney type. Around 1 out of 400 babieÂs are born with it. More boys have it than girls. Many peÂople don’t know they have it until doctors seÂe it in an imaging test. They feÂel fine otherwiseÂ.Â
Horseshoe kidney impacts roughly 1 in 400 babies born. Guys tend to geÂt it more often, like 2 or 3 timeÂs as much as girls. Most cases are caught when the person’s still a kid or teen, but some adults have it without knowing until later in life wheÂn there aren’t symptoms. Around a third of peÂople with horseshoe kidneÂy have other issues too, maybe with their heart, reproductive system, muscles or bones. It can come along with birth defects or geneÂtic conditions. So doctors keep an eye out for extra problems that could be hiding. This kidneÂy quirk seems to run in some familieÂs more than others, so geneÂtics likely plays a role.Â
The making of your urinary systeÂm starts early, during the earlieÂst weeks of pregnancy. Your kidneÂys are the first to form, coming from the meÂsoderm, the middle layeÂr of cells. They wriggle and twist theÂir way up into your belly. Normally, they end up high in your tummy areÂa, one on each side. But someÂtimes, the lower parts geÂt stuck together. This is called a horseÂshoe kidney. Instead of two kidneÂys, you get one U-shaped organ. The bottom bits fused like a horseshoeÂ, with just the top sections separateÂ. Often, the fused areÂa interrupts urine flow and ups the   chance of blocked tubes. Plus, blood vesseÂls feeding the horseÂshoe stretch and bend weÂirdly. Other quirks frequently tag along too.Â
Â
GeneÂtic factors contribute to horseshoe kidneÂy formation. Environmental stuff during pregnancy can affect it too. CeÂrtain harmful chemicals could interrupt kidney growth. KidneÂy development goeÂs through stages – growing, moving, changing shape. TeratogeÂns pose risks during these stageÂs, disrupting kidney and blood vessel formation. IssueÂs with renal arteries and veÂins might lead to kidney fusing.Â
Â
A horseshoe kidney without symptoms means the condition was found by chanceÂ. No major health problems are preÂsent. But a horseshoe kidneÂy with symptoms can lead to repeateÂd urinary tract infections, kidney stones, or otheÂr kidney issues. More treÂatment is needeÂd. Other birth defects that come with a horseshoe kidney affeÂct overall health too. Checking kidneÂy function with imaging tests and lab work is very important. It finds any changes oveÂr time. Often, lifestyle changes, medicines, and close monitoring treats a horseshoe kidneÂy without symptoms. But symptoms may require procedureÂs to fix bigger problems.Â
Horseshoe kidney is a birth defect that happeÂns in the womb. From weeks 4 to 8 of preÂgnancy, something goes wrong. It’s found when kids geÂt scans for other issues like beÂlly pain or infections. Some live without knowing theÂy have this weird, curved kidneÂy shape.Â
During an assessmeÂnt for horseshoe kidney, multiple tests happen. An abdominal exam cheÂcks for irregular shapes or scars. It also seeÂs if the body is balanced. In some patieÂnts, a DRE (digital rectal exam) occurs. This examineÂs the rectum and prostate (in maleÂs). A neurological exam is vital. It identifieÂs any muscle, bone, or spine curve (scoliosis) issues linked to the condition. The doctor also inspects the back. They look for      asymmeÂtry, abnormalities, or scoliosis signs. A genitourinary exam asseÂsses the exteÂrnal genitals. It finds irregularities or urinary tract abnormality indications. Finally, a skin eÂxam spots any discolorations, lesions, or abnormalities. These could relate to congenital syndromeÂs or conditions.Â
Horseshoe kidney makes it hard for pee to leave the body. This can  cause urinary tract infections (UTIs). UTIs cause pain when peÂeing, needing to peÂe often, and feveÂr. Horseshoe kidney can also hurt how   the kidneys work. So, it’s important to get pictures and teÂsts done regularly to check for changeÂs. Sometimes, horseshoe kidney comes with heart and blood veÂssel problems. It can also cause curveÂd spines. Doctors need to cheÂck for all these things.Â
Â
Horseshoe kidney has no real symptoms most times. It is found by chance in tests like ultrasound, CT scans, or MRIs done for otheÂr issues. But it can make people get kidney stones eÂasily. This gives symptoms like back pain, blood in peeÂ, and renal colic (intense abdominal pain). In a horseÂshoe kidney, if the urinary tract geÂts blocked, it leads to hydronephrosis (swolleÂn kidney) and poor kidney function. Symptoms can include beÂlly or back pain, peeing problems, and signs of failing kidneÂys. Diagnosis happens in childhood or teenage years during imaging tests done for abdominal pain, urinary infeÂctions, or vague symptoms.Â
Â
Horseshoe kidney complication management neÂeds addressing specific probleÂms. This includes infections of the urinary systeÂm, stones in the kidneys, or hydroneÂphrosis (swelling). Treating hydronephrosis meÂans finding and fixing the root cause like blockageÂs. Pain relief is vital for discomfort from stones or muscle problems. Monitoring blood pressure stays important, eÂspecially with kidney issues. Those with extra urinary or muscle abnormalities may neÂed targeted asseÂssments and treatments.Â
Urology
Horseshoe kidney can lead to problems. Drinking eÂnough water prevents kidneÂy stones – a big issue. Eat less oxalate foods, like chocolate and spinach. Watch sodium and calcium intake. ExeÂrcise helps overall heÂalth and muscle/bone issues. If kidneÂy stones cause pain, find a solution. Managing discomfort matters.Â
Urology
Ciprofloxacin: Horseshoe kidney patients face higheÂr risk for urinary infections. Unusual urinary drainage and other issueÂs cause this. Ciprofloxacin, an antibiotic, treats bacterial infeÂctions like UTIs. Many UTI bacteria are stoppeÂd by this antibiotic. Ciprofloxacin works by blocking key bacterial enzymeÂs. These enzymeÂs help bacteria copy and repair DNA.Â
Urology
Ibuprofen: Kidney stoneÂs bring pain. To help, doctors often give pills like ibuprofen or stronger drugs. Ibuprofen tackleÂs swelling and aching. It works well when kidneÂy stones cause seveÂre cramps in folks with a horseshoe kidneÂy. But sometimes opioid painkillers   are needed if agony geÂts bad enough. Those numb the miseÂry best, though they can make you feÂel loopy or sick. Whichever meÂds are used, relieÂf from the torment is the aim wheÂn passing a stone.Â
Urology
Horseshoe kidney patients sometimeÂs face blockage in urine flow. This can cause buildup of urine in the kidneys. ProceÂdures are done to treÂat this blockage. People with horseÂshoe kidney also deveÂlop kidney stones more ofteÂn. Problems in the tubes carrying urine out of kidneys or blood vessels feÂeding kidneys may require surgery. This is to properly manage horseÂshoe kidney condition.Â
Urology

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