Mild dose- 15 mg/day orally divided 3 times daily, depending on the severity of the condition
Moderate- Initially 30-40 mg/day orally divided 3 times daily
Severe- 60 mg/day orally divided 3 times daily
Maintenance dose- 5-30 mg/day orally divided 3 times daily
Thyrotoxicosis
(Off-label)
15-20 mg orally every 4 hours in the initial day as an adjunct
Reduce the frequency to each day or every 12 hours once patient gets stable

300-450 mg orally divided every 8 hours, depending on the severity of the condition
(A dose of 600-900 mg/day maybe required)
Maintenance dose- 100-150 mg orally divided every 8 hours
Thyrotoxic Crisis
(Off-label)
Initially 200-300 mg orally every 4-6 hours on 1st day
Reduce the dose gradually
Maintenance dose- 100-150 mg/day divided 2-3 times daily

4-10 mCi orally (or 148-370 MBq)
Larger doses are required in the case of toxic nodular goiters, and several other severe thyroid conditions

The hyperactive thyroid gland, or hyperthyroidism, is treated with it. Before thyroid surgery or radioactive iodine therapy, it is also used to alleviate the symptoms of hyperthyroidism
This medication functions by reducing the synthesis of thyroxine
First, titrate the dosage against thyroid function until euthyroidism is attained (15–60 mg via oral administration per day in two–three separate doses)
Maintenance: To maintain a euthyroid condition, take 5–15 mg daily (this can be taken in one dose if necessary)
Initial blocking-replacement dosage: 20–60 mg taken once a day along with levothyroxine. Duration of treatment: 6–18 months

Dose Adjustments

Limited data is available

In studies it is effective to treat thyroids and related disorder in adults

Initially 0.5-0.7 mg/kg orally each day or divided 3 times daily
Maintenance dose- 0.2 mg/kg orally each day or divided 3 times daily
Do not exceed more than 30 mg/day
Thyrotoxicosis
(Off-Label)
0.5-1 mg/kg orally divided 3 times daily
Based on the patient’s response, adjust the subsequent doses/duration of treatment

Indicated in children for hyperthyroidism only
For neonates, less than 28 days old: 5-10 mg/kg orally divided 3 times daily
For <6 years: 5-7 mg/kg orally divided 3 times daily
For 6-10 years: 50-150 mg orally divided 3 times daily
For >10 years: 150-300 mg orally divided daily
Maintenance dose: Usually one to two third of the intial dose 2-3 times daily based on the response

Use in kids and teenagers (3 to 17 years old)
The initial daily dosage is typically 15 mg, with adjustments made based on response
Use in young children (two years and under)
It's safety and effectiveness in children under the age of two have not been thoroughly studied. For children under two years old, it is not advised to use this medication

Dose Adjustments

N/A