World’s First Human Implant of a 3D-Printed Cornea Restores Sight
December 15, 2025
Background
Injection drug use involves using a syringe to administer drugs into the bloodstream.
Injecting drug use causes numerous complications and increases risks of infectious disease transmission through sharing needles.
Recent UN reports estimate 14.2 million cases worldwide engage in injectable drug use thus it is raising health-related concerns due to associated risks.
The commonly injected drugs are heroin, amphetamines, benzodiazepines, buprenorphine, barbiturates, and cocaine injected.
Injection drug use surged with 19th century injectable drug development.
It expanded with synthetic opioids and stimulants in urban areas lacking addiction treatment and harm reduction services.
Epidemiology
UNODC’s 2021 World Drug Report states that 269 million people used illicit drugs in 2018.
Injecting drug use is prevalent in Eastern Europe, Central Asia, Transcaucasia, and North America, exceeding global averages
Injection drug users have an estimated annual mortality of 3 to 4%.
Concerns arise that the number of people who inject drugs has increased during and potentially after the pandemic.
Anatomy
Pathophysiology
Injecting a drug intravenously delivers a rapid and powerful high through a bolus.
Drug effects start in 15 to 30 seconds intravenously and 3 to 5 minutes intramuscularly or subcutaneously.
Substance injection leads to medical issues from pathogens and contaminants due to shared needles and improper techniques.
The injected substance can cause life-threatening outcomes with heroin overdose causes respiratory depression, coma, and pulmonary edema.
Etiology
The causes of injection drug use are:
Biological Factor
Psychological Factors
Social and Environmental Factors
Transition to Injection
Genetics
Prognostic Factors
Longer durations cause poorer outcomes including chronic conditions, addiction, social disconnection, and worsened prognosis from complications.
Strong social networks and stable housing improve recovery outcomes through enhanced support and engagement in programs.
Early and sustained participation in evidence-based interventions positively influences prognosis and outcomes.
Needle exchange programs and supervised injection sites reduce infectious disease and overdose risks.
Clinical History
Collect details including chief complaint, history of present illness, and past medical history to understand clinical history of patient.
Physical Examination
Skin Examination
Cardiovascular Examination
Respiratory Examination
Gastrointestinal Examination
Neurological Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Acute symptoms are:
Respiratory depression, cyanosis, unresponsiveness, agitation, tachycardia, seizures, hyperthermia
Chronic symptoms are:
Persistent pain, scarring, collapsed veins
Differential Diagnoses
Cellulitis
Pneumonia
Histoplasmosis
Pulmonary Embolism
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Medical care for injection drug users must prioritize to manage local and systemic complications.
Patients face challenges including inadequate insurance and unstable housing, substance use, and mental examinations with thorough histories.
These individuals experienced poorly coordinated medical, mental health, and dependency of treatments.
Evaluating individuals in emergency departments for acute illness is challenging due to various complicating factors.
Localities can legally hold intoxicated individuals in emergency departments until they are stabilized for safe discharge.
Referrals for chemical dependency treatment follow stabilization of withdrawal symptoms.
The product provides 0.4 mg for IM or SC administration in the thigh, with visual and voice instructions to seek emergency care post-use.
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-non-pharmacological-approach-for-injection-drug-use
Ensure recovery housing programs and trained shelter staff in harm reduction and trauma care.
Integrated care models provide comprehensive treatment in one location.
Mobile health units deliver care to remote communities effectively.
Share harm reduction information, safe practices, treatment options, and advocate for systemic policy changes.
Proper awareness about injection drug use should be provided and its related causes with management strategies.
Appointments with a psychiatrist and preventing recurrence of disorder is an ongoing life-long effort.
Use of Opioid replacement therapy
Methadone:
It inhibits ascending pain pathways to diminish the perception and response to pain.
Buprenorphine:
It exerts agonistic effects at mu and delta opioid receptors in CNS.
Use of Opioid Reversal Agents
Naltrexone:
It is opioid competitive receptor antagonist that shows highest affinity.
Naloxone:
It is a short-acting and pure opioid antagonist is used to reverse opioid intoxication.
use-of-intervention-with-a-procedure-in-treating-injection-drug-use
Procedural interventions address both acute medical complications and long-term management including central line placement, joint aspiration, chest tube placement, and venous thrombectomy.
use-of-phases-in-managing-injection-drug-use
In the acute diagnosis phase, the focus is to address life-threatening conditions and stabilize the patient clinically.
Pharmacologic therapy is effective in the treatment phase as it includes the use of opioid replacement therapy and opioid reversal agents.
In supportive care and management phase, patients should receive required attention such as lifestyle modification and surgical interventional therapies.
The regular follow-up visits with the psychiatrist are scheduled to check the improvement of patients along with treatment response.
Medication
Future Trends
Injection drug use involves using a syringe to administer drugs into the bloodstream.
Injecting drug use causes numerous complications and increases risks of infectious disease transmission through sharing needles.
Recent UN reports estimate 14.2 million cases worldwide engage in injectable drug use thus it is raising health-related concerns due to associated risks.
The commonly injected drugs are heroin, amphetamines, benzodiazepines, buprenorphine, barbiturates, and cocaine injected.
Injection drug use surged with 19th century injectable drug development.
It expanded with synthetic opioids and stimulants in urban areas lacking addiction treatment and harm reduction services.
UNODC’s 2021 World Drug Report states that 269 million people used illicit drugs in 2018.
Injecting drug use is prevalent in Eastern Europe, Central Asia, Transcaucasia, and North America, exceeding global averages
Injection drug users have an estimated annual mortality of 3 to 4%.
Concerns arise that the number of people who inject drugs has increased during and potentially after the pandemic.
Injecting a drug intravenously delivers a rapid and powerful high through a bolus.
Drug effects start in 15 to 30 seconds intravenously and 3 to 5 minutes intramuscularly or subcutaneously.
Substance injection leads to medical issues from pathogens and contaminants due to shared needles and improper techniques.
The injected substance can cause life-threatening outcomes with heroin overdose causes respiratory depression, coma, and pulmonary edema.
The causes of injection drug use are:
Biological Factor
Psychological Factors
Social and Environmental Factors
Transition to Injection
Longer durations cause poorer outcomes including chronic conditions, addiction, social disconnection, and worsened prognosis from complications.
Strong social networks and stable housing improve recovery outcomes through enhanced support and engagement in programs.
Early and sustained participation in evidence-based interventions positively influences prognosis and outcomes.
Needle exchange programs and supervised injection sites reduce infectious disease and overdose risks.
Collect details including chief complaint, history of present illness, and past medical history to understand clinical history of patient.
Skin Examination
Cardiovascular Examination
Respiratory Examination
Gastrointestinal Examination
Neurological Examination
Acute symptoms are:
Respiratory depression, cyanosis, unresponsiveness, agitation, tachycardia, seizures, hyperthermia
Chronic symptoms are:
Persistent pain, scarring, collapsed veins
Cellulitis
Pneumonia
Histoplasmosis
Pulmonary Embolism
Medical care for injection drug users must prioritize to manage local and systemic complications.
Patients face challenges including inadequate insurance and unstable housing, substance use, and mental examinations with thorough histories.
These individuals experienced poorly coordinated medical, mental health, and dependency of treatments.
Evaluating individuals in emergency departments for acute illness is challenging due to various complicating factors.
Localities can legally hold intoxicated individuals in emergency departments until they are stabilized for safe discharge.
Referrals for chemical dependency treatment follow stabilization of withdrawal symptoms.
The product provides 0.4 mg for IM or SC administration in the thigh, with visual and voice instructions to seek emergency care post-use.
Psychiatry/Mental Health
Ensure recovery housing programs and trained shelter staff in harm reduction and trauma care.
Integrated care models provide comprehensive treatment in one location.
Mobile health units deliver care to remote communities effectively.
Share harm reduction information, safe practices, treatment options, and advocate for systemic policy changes.
Proper awareness about injection drug use should be provided and its related causes with management strategies.
Appointments with a psychiatrist and preventing recurrence of disorder is an ongoing life-long effort.
Psychiatry/Mental Health
Methadone:
It inhibits ascending pain pathways to diminish the perception and response to pain.
Buprenorphine:
It exerts agonistic effects at mu and delta opioid receptors in CNS.
Psychiatry/Mental Health
Naltrexone:
It is opioid competitive receptor antagonist that shows highest affinity.
Naloxone:
It is a short-acting and pure opioid antagonist is used to reverse opioid intoxication.
Psychiatry/Mental Health
Procedural interventions address both acute medical complications and long-term management including central line placement, joint aspiration, chest tube placement, and venous thrombectomy.
Psychiatry/Mental Health
In the acute diagnosis phase, the focus is to address life-threatening conditions and stabilize the patient clinically.
Pharmacologic therapy is effective in the treatment phase as it includes the use of opioid replacement therapy and opioid reversal agents.
In supportive care and management phase, patients should receive required attention such as lifestyle modification and surgical interventional therapies.
The regular follow-up visits with the psychiatrist are scheduled to check the improvement of patients along with treatment response.
Injection drug use involves using a syringe to administer drugs into the bloodstream.
Injecting drug use causes numerous complications and increases risks of infectious disease transmission through sharing needles.
Recent UN reports estimate 14.2 million cases worldwide engage in injectable drug use thus it is raising health-related concerns due to associated risks.
The commonly injected drugs are heroin, amphetamines, benzodiazepines, buprenorphine, barbiturates, and cocaine injected.
Injection drug use surged with 19th century injectable drug development.
It expanded with synthetic opioids and stimulants in urban areas lacking addiction treatment and harm reduction services.
UNODC’s 2021 World Drug Report states that 269 million people used illicit drugs in 2018.
Injecting drug use is prevalent in Eastern Europe, Central Asia, Transcaucasia, and North America, exceeding global averages
Injection drug users have an estimated annual mortality of 3 to 4%.
Concerns arise that the number of people who inject drugs has increased during and potentially after the pandemic.
Injecting a drug intravenously delivers a rapid and powerful high through a bolus.
Drug effects start in 15 to 30 seconds intravenously and 3 to 5 minutes intramuscularly or subcutaneously.
Substance injection leads to medical issues from pathogens and contaminants due to shared needles and improper techniques.
The injected substance can cause life-threatening outcomes with heroin overdose causes respiratory depression, coma, and pulmonary edema.
The causes of injection drug use are:
Biological Factor
Psychological Factors
Social and Environmental Factors
Transition to Injection
Longer durations cause poorer outcomes including chronic conditions, addiction, social disconnection, and worsened prognosis from complications.
Strong social networks and stable housing improve recovery outcomes through enhanced support and engagement in programs.
Early and sustained participation in evidence-based interventions positively influences prognosis and outcomes.
Needle exchange programs and supervised injection sites reduce infectious disease and overdose risks.
Collect details including chief complaint, history of present illness, and past medical history to understand clinical history of patient.
Skin Examination
Cardiovascular Examination
Respiratory Examination
Gastrointestinal Examination
Neurological Examination
Acute symptoms are:
Respiratory depression, cyanosis, unresponsiveness, agitation, tachycardia, seizures, hyperthermia
Chronic symptoms are:
Persistent pain, scarring, collapsed veins
Cellulitis
Pneumonia
Histoplasmosis
Pulmonary Embolism
Medical care for injection drug users must prioritize to manage local and systemic complications.
Patients face challenges including inadequate insurance and unstable housing, substance use, and mental examinations with thorough histories.
These individuals experienced poorly coordinated medical, mental health, and dependency of treatments.
Evaluating individuals in emergency departments for acute illness is challenging due to various complicating factors.
Localities can legally hold intoxicated individuals in emergency departments until they are stabilized for safe discharge.
Referrals for chemical dependency treatment follow stabilization of withdrawal symptoms.
The product provides 0.4 mg for IM or SC administration in the thigh, with visual and voice instructions to seek emergency care post-use.
Psychiatry/Mental Health
Ensure recovery housing programs and trained shelter staff in harm reduction and trauma care.
Integrated care models provide comprehensive treatment in one location.
Mobile health units deliver care to remote communities effectively.
Share harm reduction information, safe practices, treatment options, and advocate for systemic policy changes.
Proper awareness about injection drug use should be provided and its related causes with management strategies.
Appointments with a psychiatrist and preventing recurrence of disorder is an ongoing life-long effort.
Psychiatry/Mental Health
Methadone:
It inhibits ascending pain pathways to diminish the perception and response to pain.
Buprenorphine:
It exerts agonistic effects at mu and delta opioid receptors in CNS.
Psychiatry/Mental Health
Naltrexone:
It is opioid competitive receptor antagonist that shows highest affinity.
Naloxone:
It is a short-acting and pure opioid antagonist is used to reverse opioid intoxication.
Psychiatry/Mental Health
Procedural interventions address both acute medical complications and long-term management including central line placement, joint aspiration, chest tube placement, and venous thrombectomy.
Psychiatry/Mental Health
In the acute diagnosis phase, the focus is to address life-threatening conditions and stabilize the patient clinically.
Pharmacologic therapy is effective in the treatment phase as it includes the use of opioid replacement therapy and opioid reversal agents.
In supportive care and management phase, patients should receive required attention such as lifestyle modification and surgical interventional therapies.
The regular follow-up visits with the psychiatrist are scheduled to check the improvement of patients along with treatment response.

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