Injection Drug Use

Updated: December 26, 2024

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Background

Injection drug use involves using a syringe to administer drugs into the bloodstream.

Injecting drug use causes numerous complications and increases risks of infectious disease transmission through sharing needles.

Recent UN reports estimate 14.2 million cases worldwide engage in injectable drug use thus it is raising health-related concerns due to associated risks.

The commonly injected drugs are heroin, amphetamines, benzodiazepines, buprenorphine, barbiturates, and cocaine injected.

Injection drug use surged with 19th century injectable drug development.

It expanded with synthetic opioids and stimulants in urban areas lacking addiction treatment and harm reduction services.

Epidemiology

UNODC’s 2021 World Drug Report states that 269 million people used illicit drugs in 2018.

Injecting drug use is prevalent in Eastern Europe, Central Asia, Transcaucasia, and North America, exceeding global averages

Injection drug users have an estimated annual mortality of 3 to 4%.

Concerns arise that the number of people who inject drugs has increased during and potentially after the pandemic.

Anatomy

Pathophysiology

Injecting a drug intravenously delivers a rapid and powerful high through a bolus.

Drug effects start in 15 to 30 seconds intravenously and 3 to 5 minutes intramuscularly or subcutaneously.

Substance injection leads to medical issues from pathogens and contaminants due to shared needles and improper techniques.

The injected substance can cause life-threatening outcomes with heroin overdose causes respiratory depression, coma, and pulmonary edema.

Etiology

The causes of injection drug use are:

Biological Factor

Psychological Factors

Social and Environmental Factors

Transition to Injection

Genetics

Prognostic Factors

Longer durations cause poorer outcomes including chronic conditions, addiction, social disconnection, and worsened prognosis from complications.

Strong social networks and stable housing improve recovery outcomes through enhanced support and engagement in programs.

Early and sustained participation in evidence-based interventions positively influences prognosis and outcomes.

Needle exchange programs and supervised injection sites reduce infectious disease and overdose risks.

Clinical History

Collect details including chief complaint, history of present illness, and past medical history to understand clinical history of patient.

Physical Examination

Skin Examination

Cardiovascular Examination

Respiratory Examination

Gastrointestinal Examination

Neurological Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Acute symptoms are:

Respiratory depression, cyanosis, unresponsiveness, agitation, tachycardia, seizures, hyperthermia

Chronic symptoms are:

Persistent pain, scarring, collapsed veins

Differential Diagnoses

Cellulitis

Pneumonia

Histoplasmosis

Pulmonary Embolism

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

Medical care for injection drug users must prioritize to manage local and systemic complications.

Patients face challenges including inadequate insurance and unstable housing, substance use, and mental examinations with thorough histories.

These individuals experienced poorly coordinated medical, mental health, and dependency of treatments.

Evaluating individuals in emergency departments for acute illness is challenging due to various complicating factors.

Localities can legally hold intoxicated individuals in emergency departments until they are stabilized for safe discharge.

Referrals for chemical dependency treatment follow stabilization of withdrawal symptoms.

The product provides 0.4 mg for IM or SC administration in the thigh, with visual and voice instructions to seek emergency care post-use.

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

use-of-non-pharmacological-approach-for-injection-drug-use

Ensure recovery housing programs and trained shelter staff in harm reduction and trauma care.

Integrated care models provide comprehensive treatment in one location.

Mobile health units deliver care to remote communities effectively.

Share harm reduction information, safe practices, treatment options, and advocate for systemic policy changes.

Proper awareness about injection drug use should be provided and its related causes with management strategies.

Appointments with a psychiatrist and preventing recurrence of disorder is an ongoing life-long effort.

Use of Opioid replacement therapy

Methadone:

It inhibits ascending pain pathways to diminish the perception and response to pain.

Buprenorphine:

It exerts agonistic effects at mu and delta opioid receptors in CNS.

Use of Opioid Reversal Agents

Naltrexone:

It is opioid competitive receptor antagonist that shows highest affinity.

Naloxone:

It is a short-acting and pure opioid antagonist is used to reverse opioid intoxication.

use-of-intervention-with-a-procedure-in-treating-injection-drug-use

Procedural interventions address both acute medical complications and long-term management including central line placement, joint aspiration, chest tube placement, and venous thrombectomy.

use-of-phases-in-managing-injection-drug-use

In the acute diagnosis phase, the focus is to address life-threatening conditions and stabilize the patient clinically.

Pharmacologic therapy is effective in the treatment phase as it includes the use of opioid replacement therapy and opioid reversal agents.

In supportive care and management phase, patients should receive required attention such as lifestyle modification and surgical interventional therapies.

The regular follow-up visits with the psychiatrist are scheduled to check the improvement of patients along with treatment response.

Medication

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Injection Drug Use

Updated : December 26, 2024

Mail Whatsapp PDF Image



Injection drug use involves using a syringe to administer drugs into the bloodstream.

Injecting drug use causes numerous complications and increases risks of infectious disease transmission through sharing needles.

Recent UN reports estimate 14.2 million cases worldwide engage in injectable drug use thus it is raising health-related concerns due to associated risks.

The commonly injected drugs are heroin, amphetamines, benzodiazepines, buprenorphine, barbiturates, and cocaine injected.

Injection drug use surged with 19th century injectable drug development.

It expanded with synthetic opioids and stimulants in urban areas lacking addiction treatment and harm reduction services.

UNODC’s 2021 World Drug Report states that 269 million people used illicit drugs in 2018.

Injecting drug use is prevalent in Eastern Europe, Central Asia, Transcaucasia, and North America, exceeding global averages

Injection drug users have an estimated annual mortality of 3 to 4%.

Concerns arise that the number of people who inject drugs has increased during and potentially after the pandemic.

Injecting a drug intravenously delivers a rapid and powerful high through a bolus.

Drug effects start in 15 to 30 seconds intravenously and 3 to 5 minutes intramuscularly or subcutaneously.

Substance injection leads to medical issues from pathogens and contaminants due to shared needles and improper techniques.

The injected substance can cause life-threatening outcomes with heroin overdose causes respiratory depression, coma, and pulmonary edema.

The causes of injection drug use are:

Biological Factor

Psychological Factors

Social and Environmental Factors

Transition to Injection

Longer durations cause poorer outcomes including chronic conditions, addiction, social disconnection, and worsened prognosis from complications.

Strong social networks and stable housing improve recovery outcomes through enhanced support and engagement in programs.

Early and sustained participation in evidence-based interventions positively influences prognosis and outcomes.

Needle exchange programs and supervised injection sites reduce infectious disease and overdose risks.

Collect details including chief complaint, history of present illness, and past medical history to understand clinical history of patient.

Skin Examination

Cardiovascular Examination

Respiratory Examination

Gastrointestinal Examination

Neurological Examination

Acute symptoms are:

Respiratory depression, cyanosis, unresponsiveness, agitation, tachycardia, seizures, hyperthermia

Chronic symptoms are:

Persistent pain, scarring, collapsed veins

Cellulitis

Pneumonia

Histoplasmosis

Pulmonary Embolism

Medical care for injection drug users must prioritize to manage local and systemic complications.

Patients face challenges including inadequate insurance and unstable housing, substance use, and mental examinations with thorough histories.

These individuals experienced poorly coordinated medical, mental health, and dependency of treatments.

Evaluating individuals in emergency departments for acute illness is challenging due to various complicating factors.

Localities can legally hold intoxicated individuals in emergency departments until they are stabilized for safe discharge.

Referrals for chemical dependency treatment follow stabilization of withdrawal symptoms.

The product provides 0.4 mg for IM or SC administration in the thigh, with visual and voice instructions to seek emergency care post-use.

Psychiatry/Mental Health

Ensure recovery housing programs and trained shelter staff in harm reduction and trauma care.

Integrated care models provide comprehensive treatment in one location.

Mobile health units deliver care to remote communities effectively.

Share harm reduction information, safe practices, treatment options, and advocate for systemic policy changes.

Proper awareness about injection drug use should be provided and its related causes with management strategies.

Appointments with a psychiatrist and preventing recurrence of disorder is an ongoing life-long effort.

Psychiatry/Mental Health

Methadone:

It inhibits ascending pain pathways to diminish the perception and response to pain.

Buprenorphine:

It exerts agonistic effects at mu and delta opioid receptors in CNS.

Psychiatry/Mental Health

Naltrexone:

It is opioid competitive receptor antagonist that shows highest affinity.

Naloxone:

It is a short-acting and pure opioid antagonist is used to reverse opioid intoxication.

Psychiatry/Mental Health

Procedural interventions address both acute medical complications and long-term management including central line placement, joint aspiration, chest tube placement, and venous thrombectomy.

Psychiatry/Mental Health

In the acute diagnosis phase, the focus is to address life-threatening conditions and stabilize the patient clinically.

Pharmacologic therapy is effective in the treatment phase as it includes the use of opioid replacement therapy and opioid reversal agents.

In supportive care and management phase, patients should receive required attention such as lifestyle modification and surgical interventional therapies.

The regular follow-up visits with the psychiatrist are scheduled to check the improvement of patients along with treatment response.

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