RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
it has been widely used as an insecticide to protect crops, manage insects in houses, and manage internal and external parasites in domestic animals and livestock
It has been widely used as an insecticide to protect crops, manage insects in houses, and manage internal and external parasites in domestic animals and livestock
Insect repellent (off-label)
Applied directly to the skin or garments
Guide for In Vitro Use:
CHO (Chinese Hamster ovary) cells (HGPT locus) were subjected to a forward gene mutation assay with a dose range of 1.0-4.5 mg/ml
Although this usually doesn't cause skin irritation, it can cause chemical conjunctivitis
It works as a typical insect repellent for mosquitoes, black flies, chiggers, and other biting ins:
Dose Adjustments
N/A
(off-label):
It is not for human use Inhalation LC50 in rats over dose of 1.2 mg/L indicates category III with slight toxicity potential.
for veterinary use only
for Flea infestations
Administer dose of 15 mg/kg to dogs in month
Administer dose of 25 mg/kg to cats in month
Future Trends
References

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