1-2 g IV or IM was given once a day or in equally divided doses 2x a day
maximum duration of therapy is 4-14 days
prolonged treatment recommends for complicated infections
At least treatment given ten days for diseases due to streptococcus
For mild infection of bones and joints, a dose of 500 mg orally every 12 hours or 400 mg intravenously every 12 hours is indicated for 4-6 weeks
For severe infection of bones and joints, a dose of 750 mg orally every 12 hours or 400 mg intravenously every 8 hours is indicated for 4-6 weeks
For mild infection of bones and joints, a dose of 500 mg orally every 12 hours or 400 mg intravenously every 12 hours is indicated for 4-6 weeks
For severe infection of bones and joints, a dose of 750 mg orally every 12 hours or 400 mg intravenously every 8 hours is indicated for 4-6 weeks
For mild infection of bones and joints, a dose of 500 mg orally every 12 hours or 400 mg intravenously every 12 hours is indicated for 4-6 weeks
For severe infection of bones and joints, a dose of 750 mg orally every 12 hours or 400 mg intravenously every 8 hours is indicated for 4-6 weeks
The usual dose for the treatment of joint infection is 1 to 4 g via Intravenous or Intramuscular administration twice or thrice a day for up to 3 or 4 weeks. The duration of the treatment depends on the severity and the nature of the infections
In the case of prosthetic joint infection, therapy is prolonged for up to 6 weeks
If the infection is severe, the dose can be increased up to 12 g per day
Dose Adjustments
Renal Dose Adjustment In case of renal insufficiency, the usual dose of ceftizoxime depends on the CrCl. If the CrCl is below 5 mL/min, then 0.25-0.5 g a day or 0.5-1 g via IV or IM in 2 days after undergoing dialysis. Loading dose is standard in renal insufficiency, which is 0.5-1 g. 0.25 -1g twice a day if CrCl falls between 5 and 49 mL/min and 0.5 – 1.5 g thrice a day if CrCl is between 50 and 79 mL/min
IDSA Recommends a dose of 1.5-2 g per day given IV every 4-6hrs
3g IV every 4 hours for 3 to 4 weeks, depending on the severity of the infection
For prosthetic joint infections, longer therapy may be given of up to 6 weeks
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