malignant glioma

Updated: July 14, 2022

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

carmustine

7.7 mg 8 wafers i.e., 61.6 mg of total dose implanted intracranially

aminolevulinic acid oral

Take 20 mg/kg orally approximately 3 hours prior to induction of anesthesia
Dosage Modifications Renal impairment: dose modification not known Hepatic impairment: study not conducted
Dosage Considerations Only neurosurgeons who have completed a course on the use of fluorescence in surgery should use it

tovorafenib

Indicated for glioma
Based on BSA the recommended dose for tablet as follows
BSA: ≥ 1.40: Take 600 mg one time a week
1.13-1.39: Take 500 mg one time a week
0.90-1.12: Take 400 mg one time a week
Based on BSA the recommended dose for suspension as follows:
BSA:
≥1.40: Take 600 mg one time a week with dose volume of 24 ml
1.26-1.39: Take 525 mg one time a week with dose volume of 21 ml
1.06-1.25: Take 450 mg one time a week with dose volume of 18 ml
0.90-1.05: Take 275 mg one time a week with dose volume of 15 ml
0.84-0.89: Take 365 mg one time a week with dose volume of 14 ml
0.78-0.83: Take 300 mg one time a week with dose volume of 12 ml
0.64-0.77: Take 275 mg one time a week with dose volume of 11 ml
0.55-0.63: Take 225 mg one time a week with dose volume of 9 ml
0.49-0.54: Take 200 mg one time a week with dose volume of 8 ml
0.43-0.48: Take 175 mg one time a week with dose volume of 7 ml
0.36-0.42: Take 150 mg one time a week with dose volume of 6 ml
0.30-0.35: Take 125 mg one time a week with dose volume of 5 ml