The medical food stuff is specifically developed for the dietary clinical management of inflammation, pain and sensory loss associated with peripheral neuropathy
Take two capsules orally twice daily
The regular release of capsules
50 mg orally every 8 hours initially
Maintenance: When required, increase to 100 mg orally three times a day within one week; do not exceed more than 300 mg/day
Extended-release tablets
165 mg orally every day initially
Maintenance: Based on the response and the tolerability, increase to 330 mg orally every Day within one week; do not exceed more than 330 mg orally every day
oral solution and Regular-release capsules only
Starting dose: 75 mg orally every 12 hours (150 mg daily); may be increased to 300 mg orally divided every 12 hours within one week
If pain relief is insufficient after 2-3 weeks and the 300 mg daily dose is tolerable, the dose may be increased to 600 mg daily orally divided every 12 hours
Dose Adjustments
Dosage Modifications
Renal impairment (oral solution/capsules)
CrCl 30-60 mL/min
Reduce the dosage by 50% divided twice or thrice a day
CrCl 15-30 mL/min
If given 150 mg/day and have a normal renal function: Reduce the dosage to 25-50 mg/day; give every day or twice a day
If given 300 mg/day and have a normal renal function: Reduce the dosage to 75 mg/day; give every day or twice a day
If given 450 mg/day and have a normal renal function: Reduce the dosage to 100-150 mg/day; give every day or twice a day
If given 600 mg/day and have a normal renal function: Reduce the dosage to 150 mg/day; give every day or twice a day
CrCl <15 mL/min
If given 150 mg/day and have a normal renal function: Reduce the dosage to 25 mg/day; every day
If given 300 mg/day and have a normal renal function: Reduce the dosage to 25-50 mg/day; every day
If given 450 mg/day and have a normal renal function: Reduce the dosage to 50-75 mg/day; every day
If given 600 mg/day and have a normal renal function: Reduce the dosage to 75 mg/day; every day
Supplemental dosage following hemodialysis
25 mg daily regimen: Take one 25 mg or 50 mg supplementary dosage every day
25-50 mg daily regimen: Take one 50 mg or 75 mg supplementary dosage every day
50-75 mg daily regimen: Take one 75 mg or 100 mg supplementary dosage every day
75 mg daily regimen: Take one 100 mg or 150 mg supplementary dosage every day
Renal impairment (oral solution)
CrCl 30-60 mL/min
If given 165 mg/day and have a normal renal function: Reduce the dosage to 82.5 mg/day
If given 330 mg/day and have a normal renal function: Reduce the dosage to 165 mg/day
If given 495 mg/day and have a normal renal function: Reduce the dosage to 247.5 mg/day
If given 660 mg/day and have a normal renal function: Reduce the dosage to 330 mg/day
hemodialysis or CrCl <30 mL/min
Usually not recommended
Only capsules or oral solutions should be given to patients
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