Not recommended for poisoning now
Presently, the medication of choice is activated charcoal
15-30 ml orally once
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
Gastric lavage should be performed if vomiting doesn’t occur 30-45 minutes later the second dose
Intake of the syrup with 3-4 glasses of water
As soon as possible, administer one spray (2.7 mg) intranasally into the nose.
If the patient does not respond or respiratory depression recurs after an initial reaction, provide extra doses using a fresh nasal spray.
Administer again in 2-5 minutes if necessary until medical help arrives.
Dose Adjustments
Dosage adjustment of partial agonist or a mixed agonist/antagonist
Partial agonists or mixed agonist/antagonist drugs (such as buprenorphine or pentazocine) may only partially reverse respiratory depression, necessitating repeated intranasal administration of nalmefene.
Not recommended for childhood poisoning now
Presently, the medication of choice is activated charcoal
For 6-12 months- 5-10 ml once with half or one cup of water under medical supervision
For 1-12 years- 15 ml orally once with 1-2 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
For more than 12 years- 15-30 ml orally once with 3-4 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
Gastric lavage should be performed if vomiting doesn’t occur 30-45 minutes later the second dose
Intake of the syrup with 3-4 glasses of water
<12 years: Safety and efficacy not established
>12 years:
As soon as possible, administer one spray (2.7 mg) intranasally into the nose.
If the patient does not respond or respiratory depression returns after an initial reaction, provide extra doses using a fresh nasal spray.
Administer again in 2-5 minutes if necessary until medical help arrives.
Dose Adjustments
Dosage adjustment of partial agonist or a mixed agonist/antagonist
Partial agonists or mixed agonist/antagonist drugs (such as buprenorphine or pentazocine) may only partially reverse respiratory depression, necessitating repeated intranasal administration of nalmefene.
Presently, the medication of choice is activated charcoal
For 6-12 months- 5-10 ml once with half or one cup of water under medical supervision
For 1-12 years- 15 ml orally once with 1-2 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
For more than 12 years- 15-30 ml orally once with 3-4 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
Gastric lavage should be performed if vomiting doesn’t occur 30-45 minutes later the second dose
Presently, the medication of choice is activated charcoal
For 6-12 months- 5-10 ml once with half or one cup of water under medical supervision
For 1-12 years- 15 ml orally once with 1-2 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
For more than 12 years- 15-30 ml orally once with 3-4 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
Gastric lavage should be performed if vomiting doesn’t occur 30-45 minutes later the second dose
Presently, the medication of choice is activated charcoal
For 6-12 months- 5-10 ml once with half or one cup of water under medical supervision
For 1-12 years- 15 ml orally once with 1-2 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
For more than 12 years- 15-30 ml orally once with 3-4 glasses of water
Repeat with 15 ml once again if emesis doesn’t occur within 20-30 minutes
Gastric lavage should be performed if vomiting doesn’t occur 30-45 minutes later the second dose
Give as soon as necessary and within 24 hours if methotrexate level is >10-6 M or 48-hour level is >9 x 10-7 M, leucovorin dose should be raised to 100 mg/m2 intravenous every three hours until methotrexate level is below 10-8 M
High Dose of Methotrexate Rescue
10 mg/m2 Intravenous 4 times a day for 10 doses; begins 24 hours following the methotrexate injection
May give orally after 1st intravenous dose
Dose Adjustments
urinary alkalinization of Hydration (3 litres per day) with Na2CO3 solution should be used concomitantly; the dosage of the bicarbonate solution should be adjusted to the urine's pH at 7.0 or higher
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