Premature Labor

Updated: July 17, 2023

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

hydroxyprogesterone caproate

Indicated for Premature Labor
Treatment should start between 16.0 to 20.6 weeks of gestation. Intramuscularly (IM): 250 mg IM one time a week in the upper outer quadrant of gluteus maximus.
Subcutaneously: 275 mg SC one time a week in the back of either upper arm.
Duration: Continue administration one time a week until week 37 of gestation or delivery, whichever occurs first.

hexoprenaline

Slowly Inject 10 mcg hexoprenaline sulfate as a loading dose intravenously for 5 to 10 minutes
Initial infusion should be injected at a rate of 0.3 mcg/minute
In cases where there is no alteration in cervical condition, prolonged infusion should be given at a rate of 0.075mcg/minute

allylestrenol

Indicated for premature labour prevention
Take 10-40 mg orally daily for seven days

terbutaline

2.5-5 mcg/min IV initially;
Increase after 20–30-minute intervals; effective dose is between 17.5-30 mcg/min IV; In some cases, require doses up to 70-80 mcg/min
Continue 12 hr; should not exceed more than 48-72 hr
Orally use or prolonged IV use is not recommended.

Dose Adjustments

Renal Impairment
reduce dose by 50%, if GFR <50 mL/min
Dose adjustment is not necessary, if GFR >50mL/min

atosiban

6.75mg/0.9ml is given intravenously once a day

Future Trends