Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
Background
A spinal cord injury (SCI) develops when the spinal cord is damaged by preventing signals from being sent among the brain and the other parts of the body. Damage of this kind can cause loss of feeling and movement and in extreme situations it might cause paralysis.Â
There are two main categories of injuries to the spinal cord:Â
Traumatic SCI occurs by a sudden impact on the cervical spine such as a vehicle accident or act of violence. The spinal cord may be harmed by the force of impact by fracturing or dislocating the vertebrae.Â
Non-traumatic SCI frequently caused degenerative disorders of joints, cancer and inflammation.Â
Epidemiology
The incidence rate of spinal cord injury in the US is around 40% incidences/million people or 12,000 new cases each year. Based on statistics from 1990s to 2010 approximately 265,000 individuals were with SCI. In 2005 66.5% White, 26.8% Black, 8.3% Hispanic and 2.0% Asian people are the SCI sufferers.Â
80.7% of reported injuries in men are four times more likely than women to suffer these types of injuries.Â
Anatomy
Pathophysiology
Type and Incidence of SCI: There are around 12,000 new instances of SCI yearly in the United States which are said to be affecting approximately 40 persons per million. After an accident, the level of the damage may change; it usually gets worse in a few days. Vasogenic edema, free radicals and changed blood flow are examples of pathophysiologic processes. SCI is frequently caused by ischemia, direct trauma and compression.Â
Etiology
Total cases of SCI majority are because of a motor vehicle accident (40. 4%). Fall rates are higher in > 45 years with an average of 27. 9 %. It was clearly established that women are more likely to have osteoporosis and are more likely to develop spinal fractures.Â
15% of cases comprise interpersonal violence, bullet shots are the common cause of spinal cord injuries in different regions like several metropolitan areas. Stab and gunshot injuries to spinal cord are usually associated with neurological damage that can be worsen than tissue damage.Â
Sports Injuries 8. 0% are possible cause in diving and explained by 21 of the participants.Â
Genetics
Prognostic Factors
Clinical History
Young children may experience trauma from non-accidental injuries, sports-related accidents or falls and they may show symptoms of spinal cord dysfunction and motor deficiencies. Recreational activities such as sports injuries and car accidents are common causes. It is possible for adolescents to sustain compression injuries, dislocations or fractures. Middle-aged people may experience degenerative spine illnesses due to work-related injuries and auto accidents. Osteoporosis raises the risk of fractures and degenerative spinal disorders such spinal stenosis which make falls more common among older persons.Â
Physical Examination
Neurological examinationÂ
Sensory examinationÂ
Autonomic function assessmentÂ
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Spinal Cord CompressionÂ
Peripheral Nerve InjuryÂ
Guillain-BarrĂ© Syndrome (GBS)Â
Transverse MyelitisÂ
Cauda Equina SyndromeÂ
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Trauma & Critical Care for Spinal Cord InjuryÂ
Diagnostic Imaging:Â
Medical Management:Â
Respiratory Support:Â Â
Surgical Interventions:Â
Rehabilitation:Â
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-a-non-pharmacological-approach-for-treating-spinal-cord-injury
Role of Glucocorticoids in the treatment of Spinal Cord Injury
Methylprednisolone Protocol:  A continuous infusion of methylprednisolone is administered after a high dosage “loading” of the drug. Usually given eight hours after the injury, the loading dosage consists of 15 minutes of 30 mg/kg of methylprednisolone, followed by a 23-hour maintenance infusion of 5.4 mg/kg/hour.Â
Role of GABA Analogs in the treatment of Spinal Cord Injury
Pregabalin: The voltage-gated calcium channel alpha2-delta subunit is bound by it. It is comparable to GABA; however it doesn’t work with GABA receptors directly. The FDA has authorized pregabalin for the treatment of neuropathic pain brought on by spinal cord injuries. It works well to lessen neuronal hyperexcitability and lessen the symptoms of neuropathic pain.Â
use-of-intervention-with-a-procedure-in-treating-spinal-cord-injury
use-of-phases-in-managing
Phases of Spinal Cord Injury ManagementÂ
Acute Phase:Â
phase-of-rehabilitation
Medication
Acute (Off-label) :
1st hour: 30 mg/kg intravenous over the 15 minutes
Next 23 hours: 5.4 mg/kg/hr Intravenous by continuous infusion
methylprednisolone hemisuccinateÂ
Indicated for acute spinal cord injury
Initial dose: Administer 30mg/kg for 15 minutes intravenously
After 45 minutes give 5.4mg/kg/hour of continuous infusion for 24 hours
Motor recovery was higher and consistent in patients who started the treatment within 3 to 8 hours of injury to receive the same regimen uninterrupted for up to 48 hours
methylprednisolone hemisuccinateÂ
In children and infants, dosage can be decreased to ensure the efficacy of volume dosages as per the need of each case
It should be based on severity and response of individuals, but not on age or weight
The pediatric dosage should not be less than 0.5mg/kg every 24 hours
Future Trends
References
A spinal cord injury (SCI) develops when the spinal cord is damaged by preventing signals from being sent among the brain and the other parts of the body. Damage of this kind can cause loss of feeling and movement and in extreme situations it might cause paralysis.Â
There are two main categories of injuries to the spinal cord:Â
Traumatic SCI occurs by a sudden impact on the cervical spine such as a vehicle accident or act of violence. The spinal cord may be harmed by the force of impact by fracturing or dislocating the vertebrae.Â
Non-traumatic SCI frequently caused degenerative disorders of joints, cancer and inflammation.Â
The incidence rate of spinal cord injury in the US is around 40% incidences/million people or 12,000 new cases each year. Based on statistics from 1990s to 2010 approximately 265,000 individuals were with SCI. In 2005 66.5% White, 26.8% Black, 8.3% Hispanic and 2.0% Asian people are the SCI sufferers.Â
80.7% of reported injuries in men are four times more likely than women to suffer these types of injuries.Â
Type and Incidence of SCI: There are around 12,000 new instances of SCI yearly in the United States which are said to be affecting approximately 40 persons per million. After an accident, the level of the damage may change; it usually gets worse in a few days. Vasogenic edema, free radicals and changed blood flow are examples of pathophysiologic processes. SCI is frequently caused by ischemia, direct trauma and compression.Â
Total cases of SCI majority are because of a motor vehicle accident (40. 4%). Fall rates are higher in > 45 years with an average of 27. 9 %. It was clearly established that women are more likely to have osteoporosis and are more likely to develop spinal fractures.Â
15% of cases comprise interpersonal violence, bullet shots are the common cause of spinal cord injuries in different regions like several metropolitan areas. Stab and gunshot injuries to spinal cord are usually associated with neurological damage that can be worsen than tissue damage.Â
Sports Injuries 8. 0% are possible cause in diving and explained by 21 of the participants.Â
Young children may experience trauma from non-accidental injuries, sports-related accidents or falls and they may show symptoms of spinal cord dysfunction and motor deficiencies. Recreational activities such as sports injuries and car accidents are common causes. It is possible for adolescents to sustain compression injuries, dislocations or fractures. Middle-aged people may experience degenerative spine illnesses due to work-related injuries and auto accidents. Osteoporosis raises the risk of fractures and degenerative spinal disorders such spinal stenosis which make falls more common among older persons.Â
Neurological examinationÂ
Sensory examinationÂ
Autonomic function assessmentÂ
Spinal Cord CompressionÂ
Peripheral Nerve InjuryÂ
Guillain-BarrĂ© Syndrome (GBS)Â
Transverse MyelitisÂ
Cauda Equina SyndromeÂ
Trauma & Critical Care for Spinal Cord InjuryÂ
Diagnostic Imaging:Â
Medical Management:Â
Respiratory Support:Â Â
Surgical Interventions:Â
Rehabilitation:Â
Psychiatry/Mental Health
Methylprednisolone Protocol:  A continuous infusion of methylprednisolone is administered after a high dosage “loading” of the drug. Usually given eight hours after the injury, the loading dosage consists of 15 minutes of 30 mg/kg of methylprednisolone, followed by a 23-hour maintenance infusion of 5.4 mg/kg/hour.Â
Neurology
Pregabalin: The voltage-gated calcium channel alpha2-delta subunit is bound by it. It is comparable to GABA; however it doesn’t work with GABA receptors directly. The FDA has authorized pregabalin for the treatment of neuropathic pain brought on by spinal cord injuries. It works well to lessen neuronal hyperexcitability and lessen the symptoms of neuropathic pain.Â
Orthopaedic Surgery
Neurosurgery
Phases of Spinal Cord Injury ManagementÂ
Acute Phase:Â
A spinal cord injury (SCI) develops when the spinal cord is damaged by preventing signals from being sent among the brain and the other parts of the body. Damage of this kind can cause loss of feeling and movement and in extreme situations it might cause paralysis.Â
There are two main categories of injuries to the spinal cord:Â
Traumatic SCI occurs by a sudden impact on the cervical spine such as a vehicle accident or act of violence. The spinal cord may be harmed by the force of impact by fracturing or dislocating the vertebrae.Â
Non-traumatic SCI frequently caused degenerative disorders of joints, cancer and inflammation.Â
The incidence rate of spinal cord injury in the US is around 40% incidences/million people or 12,000 new cases each year. Based on statistics from 1990s to 2010 approximately 265,000 individuals were with SCI. In 2005 66.5% White, 26.8% Black, 8.3% Hispanic and 2.0% Asian people are the SCI sufferers.Â
80.7% of reported injuries in men are four times more likely than women to suffer these types of injuries.Â
Type and Incidence of SCI: There are around 12,000 new instances of SCI yearly in the United States which are said to be affecting approximately 40 persons per million. After an accident, the level of the damage may change; it usually gets worse in a few days. Vasogenic edema, free radicals and changed blood flow are examples of pathophysiologic processes. SCI is frequently caused by ischemia, direct trauma and compression.Â
Total cases of SCI majority are because of a motor vehicle accident (40. 4%). Fall rates are higher in > 45 years with an average of 27. 9 %. It was clearly established that women are more likely to have osteoporosis and are more likely to develop spinal fractures.Â
15% of cases comprise interpersonal violence, bullet shots are the common cause of spinal cord injuries in different regions like several metropolitan areas. Stab and gunshot injuries to spinal cord are usually associated with neurological damage that can be worsen than tissue damage.Â
Sports Injuries 8. 0% are possible cause in diving and explained by 21 of the participants.Â
Young children may experience trauma from non-accidental injuries, sports-related accidents or falls and they may show symptoms of spinal cord dysfunction and motor deficiencies. Recreational activities such as sports injuries and car accidents are common causes. It is possible for adolescents to sustain compression injuries, dislocations or fractures. Middle-aged people may experience degenerative spine illnesses due to work-related injuries and auto accidents. Osteoporosis raises the risk of fractures and degenerative spinal disorders such spinal stenosis which make falls more common among older persons.Â
Neurological examinationÂ
Sensory examinationÂ
Autonomic function assessmentÂ
Spinal Cord CompressionÂ
Peripheral Nerve InjuryÂ
Guillain-BarrĂ© Syndrome (GBS)Â
Transverse MyelitisÂ
Cauda Equina SyndromeÂ
Trauma & Critical Care for Spinal Cord InjuryÂ
Diagnostic Imaging:Â
Medical Management:Â
Respiratory Support:Â Â
Surgical Interventions:Â
Rehabilitation:Â
Psychiatry/Mental Health
Methylprednisolone Protocol:  A continuous infusion of methylprednisolone is administered after a high dosage “loading” of the drug. Usually given eight hours after the injury, the loading dosage consists of 15 minutes of 30 mg/kg of methylprednisolone, followed by a 23-hour maintenance infusion of 5.4 mg/kg/hour.Â
Neurology
Pregabalin: The voltage-gated calcium channel alpha2-delta subunit is bound by it. It is comparable to GABA; however it doesn’t work with GABA receptors directly. The FDA has authorized pregabalin for the treatment of neuropathic pain brought on by spinal cord injuries. It works well to lessen neuronal hyperexcitability and lessen the symptoms of neuropathic pain.Â
Orthopaedic Surgery
Neurosurgery
Phases of Spinal Cord Injury ManagementÂ
Acute Phase:Â

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