New Long-Read Genetic Test Enables Faster and More Comprehensive Diagnosis of Rare Diseases
November 18, 2025
Background
Varicose veins are dilated, swollen, and coiled veins of the skin that are ordinarily blue or dark purple in appearance. It happens when the valves in veins fail to operate effectively as they should, leading to blood stagnation in the veins. This condition mostly occurs in the legs and particularly in the feet since these are some of the most affected parts of the body when standing or walking.Â
Epidemiology
Prevalence:Â
Anatomy
Pathophysiology
Venous Valve DysfunctionÂ
Venous HypertensionÂ
Venous Wall WeaknessÂ
Genetic PredispositionÂ
Etiology
Genetics
Prognostic Factors
Clinical History
Age Group:Â
Varicose veins may be present in all generational categories but are prevalent in the middle-aged and above 50-year-old population. Women are at a higher risk of getting varicose veins, especially during pregnancy, after menopause, or during their menstrual cycle.Â
Physical Examination
InspectionÂ
PalpitationÂ
Trendelenburg testÂ
Age group
Associated comorbidity
Chronic Venous Insufficiency (CVI)Â
Deep Vein Thrombosis (DVT)Â
PhlebitisÂ
Leg UlcersÂ
LymphedemaÂ
Associated activity
Acuity of presentation
Mild PresentationÂ
Moderate PresentationÂ
Severe PresentationÂ
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Conservative Measures:Â
Minimally Invasive Procedures:Â
Surgical Options (for severe cases):Â
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
use-of-the-non-pharmacological-therapy-in-treating-varicose-veins
Effectiveness of Sclerosing agent in treating varicose veins
role-of-intervention-with-procedure-in-treating-varicose-veins
role-of-management-in-treating-varicose-veins
Conservative Management:Â
Minimally Invasive Procedures:Â
Post-Treatment Care:Â
Medication
There is no sufficient data available
Take about 1½ tablespoons after a meal daily
Telangieactasias (spider veins): 0.1 ml to 0.2 ml for an injection of 0.25%/0.5% solution
Central veins of the telangiectasias: 0.1 ml to 0.2 ml for an injection of 0.25%/0.5%/1% solution
Medium-sized varices: Nearly up to 2 ml for an injection of 2%/3% solution
Reticular and small varices: 0.1 ml to 0.3 ml for an injection of 1% solution
Large varices: Nearly up to 2 ml for an injection of 3% solution
Small saphenous veins: Nearly up to 4 ml for an injection of 2%/3% microfoam
Great saphenous veins: Nearly up to 6 ml for an injection of 2%/3% microfoam
Future Trends
Varicose veins are dilated, swollen, and coiled veins of the skin that are ordinarily blue or dark purple in appearance. It happens when the valves in veins fail to operate effectively as they should, leading to blood stagnation in the veins. This condition mostly occurs in the legs and particularly in the feet since these are some of the most affected parts of the body when standing or walking.Â
Prevalence:Â
Venous Valve DysfunctionÂ
Venous HypertensionÂ
Venous Wall WeaknessÂ
Genetic PredispositionÂ
Age Group:Â
Varicose veins may be present in all generational categories but are prevalent in the middle-aged and above 50-year-old population. Women are at a higher risk of getting varicose veins, especially during pregnancy, after menopause, or during their menstrual cycle.Â
InspectionÂ
PalpitationÂ
Trendelenburg testÂ
Chronic Venous Insufficiency (CVI)Â
Deep Vein Thrombosis (DVT)Â
PhlebitisÂ
Leg UlcersÂ
LymphedemaÂ
Mild PresentationÂ
Moderate PresentationÂ
Severe PresentationÂ
Conservative Measures:Â
Minimally Invasive Procedures:Â
Surgical Options (for severe cases):Â
Dermatology, General
Dermatology, General
Dermatology, General
Dermatology, General
Conservative Management:Â
Minimally Invasive Procedures:Â
Post-Treatment Care:Â
Varicose veins are dilated, swollen, and coiled veins of the skin that are ordinarily blue or dark purple in appearance. It happens when the valves in veins fail to operate effectively as they should, leading to blood stagnation in the veins. This condition mostly occurs in the legs and particularly in the feet since these are some of the most affected parts of the body when standing or walking.Â
Prevalence:Â
Venous Valve DysfunctionÂ
Venous HypertensionÂ
Venous Wall WeaknessÂ
Genetic PredispositionÂ
Age Group:Â
Varicose veins may be present in all generational categories but are prevalent in the middle-aged and above 50-year-old population. Women are at a higher risk of getting varicose veins, especially during pregnancy, after menopause, or during their menstrual cycle.Â
InspectionÂ
PalpitationÂ
Trendelenburg testÂ
Chronic Venous Insufficiency (CVI)Â
Deep Vein Thrombosis (DVT)Â
PhlebitisÂ
Leg UlcersÂ
LymphedemaÂ
Mild PresentationÂ
Moderate PresentationÂ
Severe PresentationÂ
Conservative Measures:Â
Minimally Invasive Procedures:Â
Surgical Options (for severe cases):Â
Dermatology, General
Dermatology, General
Dermatology, General
Dermatology, General
Conservative Management:Â
Minimally Invasive Procedures:Â
Post-Treatment Care:Â

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