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Brand Name :
N/A
Synonyms :
adenovirus types 4 and 7 live, oral
Class :
Vaccines, Live, Viral
Brand Name :
N/A
Synonyms :
adenovirus types 4 and 7 live, oral
Class :
Vaccines, Live, Viral
Dosage Forms & Strengths
Tablets
Adenovirus type 4 ≥4.5 log10 TCID50
Adenovirus type 7 ≥4.5 log10 TCID50
Single vaccine dose consists of 2 tablets:
Take one tablet each for adenovirus type 4 and adenovirus type 7
Dosing considerations
The effectiveness of the vaccine depends on the live adenovirus given orally multiplying within the intestinal tract; therefore, administer the shot later to anyone experiencing vomiting or diarrhea
Indicated for Adenovirus Active immunization
Single vaccine dose consists of 2 tablets
Take one tablet each for adenovirus type 4 and adenovirus type 7
Not determined
Refer to adult dosing
Actions and Spectrum
The live, oral adenovirus vaccines are designed to induce an immune response against adenovirus types 4 and 7.
The immune system is stimulated to produce antibodies and develop immune memory against these specific adenovirus serotypes.
Frequency defined
>10%
Headache
Cough
Diarrhea
Nasal congestion
Nausea
<1%
Gastritis
Pneumonia
Hematochezia
Hematuria
Gastroenteritis
1-10%
Fever (4.2%)
Pyrexia (1.4%)
Rhinorrhea (4.2%)
Post marketing Reports
Guillain-Barré syndrome
Hypersensitivity reactions
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The virus is modified, and it can replicate and stimulate an immune response but is not capable of causing disease in healthy individuals.
The live virus in the vaccine aims to prompt the immune system to recognize and mount a defense against adenovirus types 4 and 7.
Pharmacodynamics
The live adenovirus vaccines are the stimulation of both humoral and cellular immune responses.
The live, attenuated virus in the vaccine serves as an antigen. Antigens are substances that the immune system recognizes as foreign and against which it mounts a response.
Pharmacokinetics
Limited information available on ADME.
Administration
Adenovirus types 4 and 7 live vaccines are administered orally and available in the form of tablets.
Patient information leaflet
Generic Name: adenovirus types 4 and 7 live, oral
Why do we use adenovirus types 4 and 7 live, oral?
Adenovirus types 4 and 7 are known to cause acute respiratory disease (ARD), particularly in crowded settings like military training camps. The live, oral vaccines have been developed to prevent outbreaks of respiratory illness caused by these specific adenovirus serotypes.
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