The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Tanzeum
Synonyms :
albiglutide
Class :
Antidiabetics, Glucagon-like Peptide-1 Agonists
Brand Name :
Tanzeum
Synonyms :
albiglutide
Class :
Antidiabetics, Glucagon-like Peptide-1 Agonists
Dosage Forms & StrengthsÂ
Lyophilized Powder for ReconstitutionÂ
30mg/penÂ
50mg/penÂ
Single-use pen as injectionÂ
30 mg subcutaneously once a week
If the glycemic response is inadequate, increase to 50 mg once a week
30 mg subcutaneously once a week
Not indicated to treat severe gastric disease, type 1 diabetes mellitus, or diabetic ketoacidosis
Safety and efficacy are not seen in pediatricsÂ
Refer to the adult dosingÂ
may have an increased risk of hypoglycemia when combined with albiglutide
may increase the toxic effects
may increase the toxic effects
may increase the toxic effects
may increase the toxic effects
may increase the toxic effects
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
it may diminish the effects when combined with estradiol valerate by pharmacodynamic antagonism
When medrysone is used in conjunction with albiglutide, the risk or seriousness of hyperglycemia can rise
When used with levobetaxolol, albiglutide's therapeutic effectiveness may be improved
It may enhance the risk of bleeding when combined with nimesulide
When albiglutide is used together with polythiazide, this leads to a reduction in the therapeutic effectiveness of albiglutide
albiglutide: it may decrease the therapeutic efficacy of piperazine
the efficacy of albiglutide can be raised when used in combination with sulfametopyrazine
the potential or intensity of hyperglycemia can be heightened when flurandrenolide is combined with albiglutide
When helometasone is used together with albiglutide, this leads to elevated risk or seriousness of hyperglycemia
When albiglutide is used together with diazoxide, this leads to reduction in therapeutic effectiveness of albiglutide
methylprednisolone hemisuccinateÂ
When methylprednisolone hemisuccinate is aided with albiglutide, this leads to elevated hyperglycemia risk
when both drugs are combined, there may be a reduced therapeutic efficacy of albiglutide  
may decrease the effects of the other by pharmacodynamic antagonism
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
insulin degludec/insulin aspartÂ
may enhance the effects of the other by pharmacodynamic synergism
the risk of hyperglycemia may be increased
the therapeutic activity of albiglutide may be increased
the anti-diabetic efficacy of albiglutide can be reduced with mometasone furoate
the hypoglycemic efficiency of albiglutide can be increased
Actions and Spectrum:Â
albiglutide helps regulate blood glucose levels by stimulating insulin release from beta cells of pancreas in response to elevated blood glucose.Â
albiglutide enhances the incretin effect, increasing insulin release and decreasing glucagon secretion in response to food intake.Â
albiglutide can influence appetite and satiety, promoting a feeling of fullness and potentially reducing food intake.Â
albiglutide improves glycemic control by reducing fasting and postprandial blood glucose levels, helping to achieve target HbA1c levels.Â
albiglutide is associated with weight loss or stabilization in individuals with type 2 diabetes, potentially aiding in weight management.Â
albiglutide has been studied for its cardiovascular effects, showing a reduction in major cardiovascular events in individuals with type 2 diabetes and cardiovascular risk factors.Â
Frequency definedÂ
>10%Â
Diarrhea (10.5%)Â
Upper respiratory tract infection (13%)Â
1-10%Â
Injection site reaction (2.1%)Â
Nausea (9.6%)Â
Black Box Warning:Â
albiglutide causes C-cell thyroid tumors in rodents. Risk in humans is undetermined.Â
The drug is contraindicated in patients with a medullary thyroid carcinoma family history.
Contraindication/Caution:Â
Contraindications:Â
Cautions:Â
Pregnancy consideration:Â Â
Pregnancy Category: CÂ
Breastfeeding warnings:Â Â
The secretion of drugs in breast milk is unknown.Â
Pregnancy category:Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â Â
Pharmacodynamics:Â
By enhancing insulin secretion and reducing glucagon release, albiglutide helps regulate blood glucose levels, preventing hyperglycemia (high blood sugar).Â
albiglutide slows down the emptying of the stomach, leading to slower absorption of nutrients, including glucose. This helps control postprandial (after-meal) blood glucose levels.Â
Activation of GLP-1 receptors can influence appetite centers in the brain, resulting in reduced food intake and increased satiety.Â
Pharmacokinetics:Â
AbsorptionÂ
The peak plasma concentration is achieved in 3-5 daysÂ
The peak plasma concentration is 1.74 mcg/mLÂ
The area under the curve is 465 mcg•h/mLÂ
The steady-state concentration is achieved in 4-5 weeksÂ
DistributionÂ
The volume of distribution is 11 LÂ
The protein-bound is not assessedÂ
MetabolismÂ
The drug is catabolized in the vascular endothelium, following a path similar to native human serum albumin.Â
Elimination and ExcretionÂ
The half-life is 5 days.Â
Administration:Â
Patient information leafletÂ
Generic Name: albiglutideÂ
Pronounced as: [al-bi-GLOO-tide]Â
Why do we use albiglutide?Â
albiglutide is used primarily for the treatment of type 2 diabetes mellitus. It is also used for blood glucose control, HbA1c reduction, weight management, cardiovascular benefits, and convenient dosage.Â
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