America’s New 2025–2030 Dietary Guidelines: “Eat Real Food”
January 11, 2026
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
PROPRAZOLAM-M, ALLTOP-P, ZEPRO, ALPRONT-P,ZOPAX PLUS,ZEPRO-M
Synonyms :
alprazolam/propranolol
Class :
Anxiolytics
Brand Name :
PROPRAZOLAM-M, ALLTOP-P, ZEPRO, ALPRONT-P,ZOPAX PLUS,ZEPRO-M
Synonyms :
alprazolam/propranolol
Class :
Anxiolytics
Dosage forms and strengths
alprazolam/propranolol
0.25 mg/20 mg
0.25 mg/10 mg
A recommended initial dosage of 80 mg taken two times daily can be adjusted weekly based on the individual's response
Typically, the prescribed dosage falls within the range of 160 to 320 mg per day
When used in conjunction with diuretics or other medications for hypertension, it can lead to an additional reduction in blood pressure
Indicated for hypertrophic obstructive cardiomyopathy & thyrotoxicosis
A typical recommended dose involves taking 10 to 40 mg of the medication 3-4 times daily to achieve the desired therapeutic effect
Not indicated
Refer adult dosing
Actions and Spectrum:
Action:
alprazolam is a medication primarily classified as a benzodiazepine. Its primary function is to amplify the influence of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain to restrain excessive brain activity. alprazolam increases GABA’s inhibitory effects, leading to a calming and sedative effect on the central nervous system. This makes it useful for the management of anxiety and panic disorders.
propranolol is a beta-blocker medication that primarily works by blocking the effects of adrenaline (epinephrine) on beta-adrenergic receptors. Doing so reduces the heart rate, blood pressure, and force of heart contractions.
Spectrum:
alprazolam
alprazolam finds its primary application in the management of anxiety disorders and panic disorders. Additionally, it is occasionally employed as a supplementary treatment for depression or certain sleep-related conditions. It is not typically prescribed for other medical conditions because of its potential for dependence and withdrawal symptoms when used long-term.
propranolol
Hypertension: It is commonly prescribed to lower high blood pressure.
Angina Pectoris: propranolol can relieve the chest pain associated with angina.
Frequency not defined
Slow heart rate
Tiredness
Drowsiness
Cold extremities
Confusion
Memory impairment
Black Box Warning:
None
Contraindication/Caution:
Severe respiratory issues: The combination may further depress respiration, so it should be avoided in individuals with severe respiratory problems.
Bradycardia or heart block: The combination can slow the heart rate, so it should be used cautiously in individuals with pre-existing heart conditions.
Hypotension: The combination may lead to dangerously low blood pressure, especially in individuals prone to hypotension.
Hypersensitivity: Do not take this combination medication if you are allergic to the medication or any of its ingredients.
Pregnancy and Breastfeeding: This combination of medications is typically discouraged during pregnancy, particularly in the initial trimester, as it could elevate the likelihood of congenital abnormalities.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
alprazolam belongs to the class of drugs known as benzodiazepines; propranolol is a beta-blocker.
Pharmacodynamics:
alprazolam
alprazolam functions by increasing the influence of a neurotransmitter GABA within the brain. GABA, an inhibitory neurotransmitter, diminishes the activity of nerve cells, ultimately resulting in a soothing and sedative outcome. alprazolam attaches itself to distinct receptors in the brain, specifically the GABA-A receptors, thereby augmenting the inhibitory impact of GABA.
propranolol
propranolol functions by inhibiting the actions of adrenaline (also known as epinephrine) and various stress-related hormones on the beta-adrenergic receptors within the body. Doing so reduces heart rate, blood pressure, and the force of heart contractions, making it particularly useful in managing cardiovascular conditions and reducing anxiety symptoms.
Pharmacokinetics:
Absorption
alprazolam is well-absorbed after oral administration.
propranolol is well-absorbed after oral administration.
Distribution
alprazolam is distributed throughout the body, including the brain, due to its lipophilic nature.
propranolol is distributed throughout the body, including the heart and central nervous system.
Metabolism
alprazolam undergoes hepatic metabolism, primarily by the enzyme CYP3A4, forming active metabolites.
propranolol undergoes hepatic metabolism, primarily by the enzyme CYP2D6.
Excretion and Elimination
alprazolam and its metabolites are eliminated primarily through the kidneys.
propranolol is eliminated through the kidneys.
Administration:
The route of administration is oral. A healthcare provider may adjust the dosing based on the patient’s response and tolerance.
The combination should be taken exactly as prescribed by a healthcare professional. It’s important not to exceed or use the recommended dosage longer than prescribed.
Patient information leaflet
Generic Name: alprazolam/propranolol
Why do we use alprazolam/propranolol?
The combination is effective in treating different types of anxiety disorders. alprazolam and propranolol are often prescribed together to relieve the anxiety symptoms and physiological manifestations of anxiety, including tremors, palpitations, and perspiration.
The combination is effective in panic disorder.
propranolol may be recommended with alprazolam to alleviate the physical manifestations of panic attacks, including heightened heart rate and tremors.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
