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Brand Name :
Xerac AC, Hypercare, Certain Dri Roll-On, Drysol
Synonyms :
aluminium chloride hexahydrate
Class :
Antiperspirants, Hemostatic Agent
Brand Name :
Xerac AC, Hypercare, Certain Dri Roll-On, Drysol
Synonyms :
aluminium chloride hexahydrate
Class :
Antiperspirants, Hemostatic Agent
Dosage Forms & Strengths
Solution Drysol (20%)
35 mL
37.5 mL 6
0 mL
Xerac AC (6.25%)
35ml
60ml
Hypercare (15%)
35ml
60ml
Apply topically every day at bedtime; if excessive perspiration has subsided, reduce to one or two times weekly, or as required
Do a morning wash on the treated area
Minor bleeding; granulation tissue development
Safety and efficacy not established
Action and spectrum:
Actions:
Aluminum chloride hexahydrate blocks sweat ducts by binding to proteins in keratinocytes, reducing sweat flow and controlling conditions like underarm hyperhidrosis.
Spectrum:
Aluminium chloride hexahydrate mainly treats localized excessive sweating, especially in the axillary area.
Frequency not defined
Prickling sensation
Transient stinging of the skin
Burning sensation
Black box warning
None
Contraindications/caution:
Hypersensitivity
Irritated Skin
Kidney Dysfunction
Pregnancy/Lactation:
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Aluminium chloride hexahydrate is used as antiperspirant & Hemostatic agents.
Pharmacodynamics:
Aluminium chloride hexahydrate in antiperspirants forms plugs in sweat ducts, reducing sweat flow by blocking them. This alleviates symptoms of hyperhidrosis by decreasing sweat production.
Pharmacokinetics:
Absorption
Aluminium chloride hexahydrate is used in antiperspirants on the skin, with minimal systemic absorption.
Distribution
Aluminium chloride hexahydrate is mainly distributed locally and doesn’t spread widely throughout the body.
Metabolism
At the application site, skin cells may minimally metabolise aluminium chloride hexahydrate.
Excretion and Elimination
Aluminium chloride absorbed may excreted through sweat, but most stays at the application site.
Patient information leaflet
Generic Name: aluminum chloride hexahydrate
Why do we use Aluminum chloride hexahydrate?
The main purpose of aluminium chloride hexahydrate in personal care products is to control excessive perspiration, or hyperhidrosis, by virtue of its antiperspirant qualities.
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