aluminium chloride hexahydrate

Action and Spectrum

Action and spectrum: 

Actions: 

Aluminum chloride hexahydrate blocks sweat ducts by binding to proteins in keratinocytes, reducing sweat flow and controlling conditions like underarm hyperhidrosis. 

Spectrum: 

Aluminium chloride hexahydrate mainly treats localized excessive sweating, especially in the axillary area. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Prickling sensation  

Transient stinging of the skin  

Burning sensation 

Black Box Warning

Black box warning 

None  

Contraindication / Caution

Contraindications/caution:  

Hypersensitivity   

Irritated Skin  

Kidney Dysfunction 

Pregnancy / Lactation

Pregnancy/Lactation: 

Pregnancy consideration: Insufficient data available  

Lactation: Excretion of the drug in human breast milk is unknown  

Pregnancy category:  

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.  

Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.  

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology:  

Aluminium chloride hexahydrate is used as antiperspirant & Hemostatic agents. 

Pharmacodynamics:  

Aluminium chloride hexahydrate in antiperspirants forms plugs in sweat ducts, reducing sweat flow by blocking them. This alleviates symptoms of hyperhidrosis by decreasing sweat production. 

Pharmacokinetics: 

Absorption  

Aluminium chloride hexahydrate is used in antiperspirants on the skin, with minimal systemic absorption. 

Distribution 

Aluminium chloride hexahydrate is mainly distributed locally and doesn’t spread widely throughout the body. 

Metabolism  

At the application site, skin cells may minimally metabolise aluminium chloride hexahydrate.  

Excretion and Elimination 

Aluminium chloride absorbed may excreted through sweat, but most stays at the application site. 

Adminstartion

Administration: 

Topical Administration:  

It is applied topically to the skin. 

Patient Information Leaflet

Patient information leaflet  

Generic Name: aluminum chloride hexahydrate  

Why do we use Aluminum chloride hexahydrate?  

The main purpose of aluminium chloride hexahydrate in personal care products is to control excessive perspiration, or hyperhidrosis, by virtue of its antiperspirant qualities.