amino acid mixture d / calcium chloride dihydrate / glucose monohydrate / glycine / magnesium chloride hexahydrate / olive oil / potassium chloride / sodium acetate trihydrate / sodium glycerophosphate pentahydrate / soya-bean oil

Action and Spectrum

Actions and Spectrum: 

Actions: 

OLICLINOMEL is an IV nutritional supplement. It gives you essential amino acids, glucose, and lipids. This meets many patient needs. The balanced formula helps make proteins. It also makes energy and stops nitrogen waste buildup. It has eight essential amino acids, L-histidine,    refined olive oil, and soybean oil. These make it work better at helping you heal. OLICLINOMEL can be used in many ways. It helps improve how you feel and slows disease progress. Whether you take it by mouth or IV; it goes where it needs to go. It absorbs well and turns into what your body needs. This includes making proteins, making energy, and getting rid of waste. OLICLINOMEL plays a big part in caring for patients for many medical reasons. 

Spectrum: 

OLICLINOMEL is for IV nutrition. It has amino acids, glucose, and lipids that help patients. The amino acids come from protein. Glucose gives you energy. Lipids help your body function. OLICLINOMEL is a balanced supplement. It supports protein building and energy making and prevents fearful nitrogen buildup: histidine and eight other essential amino acids are in OLICLINOMEL. The lipid part has olive oil and soybean oil. These ingredients make OLICLINOMEL work well. Your body absorbs and uses OLICLINOMEL efficiently. It plays an important role. It aids protein creation, energy production, and waste removal. In short, OLICLINOMEL helps patients get better and slows disease progression. It contributes to comprehensive care. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Headache 

Allergic reactions 

Abnormal blood tests for hepatic function 

Diarrhea 

Raised TG 

Fluid accumulation at the site of infusion 

Infusion site swelling and pain 

Fever 

Airway constriction 

Tremor 

Breathing sounds 

Wheezing sounds 

Bronchospasm 

Vomiting 

Excessive sweating 

Hepatomegaly 

Erythema 

Reduction in platelet count 

Nausea 

Chest pain 

Exremity pain 

Abdominal pain 

Back pain 

Jaundice 

Hyperglycemia 

Necrosis 

Ulcer  

Fat overload syndrome 

Respiratory distress 

Pulmanry vascular precipitates 

Decreased WBC and platelets in children 

Black Box Warning

Black Box Warning: 

OLICLINOMEL does not usually affect coumarin derivatives when it contains vitamin K within recommended doses. However, be careful when using it with ceftriaxone. Taking them together with calcium-containing solutions could cause ceftriaxone-calcium salt to form. To avoid this, give them one after the other using separate lines or flush the line thoroughly between infusions. Be extra careful with patients taking potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, or immunosuppressants. The potassium in OLICLINOMEL could cause high potassium levels. The lipids in the emulsion may affect some lab tests for 5 to 6 hours after giving OLICLINOMEL. Giving it with blood could cause clotting     problems and destabilize the lipid emulsion. Low pH and incorrect divalent cation levels can also destabilize it. Keep calcium and phosphate levels balanced to prevent calcium phosphate             precipitation. Check if other solutions mix safely with OLICLINOMEL. Never mix ceftriaxone and calcium solutions together or give them simultaneously, as precipitation may occur. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity (amino acids, 
• Premature baby, child or an infant < 2 years 
• Hyperlipidemia 
• Abnormal increase in high electrolytes 
• Severe raise is blood sugar levels 

Cautions 

• Renal impairment 
• Abnormal symptoms and signs of any allergic reactions 
• Breathing difficulty (pulmonary vascular precipitates 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Abnormal TG levels 
• Bactericemia 
• Septicemia 
• Pediatrics 
• Cardiovascular disorders 
• Coma 
• Metabolic acidosis 
• Fat overload syndrome 
• Malnutrition 
• Infection at infusion site 
• Breastfeeding 
• Blood clotting disorders 
• Adrenal insufficiency 
• De-and hyper-hydration 
• DM 
• Pulmonary disroders 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Eight essential amino acids plus L-histidine are given to renal failure patients in amino acid therapy (Oliclinomel N4-550E/OliClinomel N7-1000E). The body can make non-essential amino acids from urea nitrogen when there’s enough    energy. This helps build proteins and stops waste nitrogen from building up. 

Pharmacodynamics: 

Simple substances make this mix. It has acids called amino acids, glucose, and fatty acids. OliClinome­l N4-550E contains glucose at 80 g/l. However, OliClinome­l N7-1000E has a higher amount of 160 g/l. These fatty acids assist in making things using unsaturated fats from olive oil, which is rich in vitamin E. 

Pharmacokinetics: 

Limited data is available 

Adminstartion

Administration: 

The dose of OLICLINOMEL depends on things like how much energy the patient needs, their health, weight, and how well their body works. You should choose the bag size based on whether they’re are also getting food by mouth or feeding tube. The infusion time can be longer if needed, but don’t give more than the maximum daily dose for adults and kids. Since the bag has fixed amounts; it might not give all the nutrients ideally so that adjustments may be needed for some conditions. The max doses are usually 17 g/kg/day for glucose, 3 g/kg/day for amino acids and lipids each, and 100 mL/kg/day for fluid, except in exceptional cases. Use OLICLINOMEL bags once only. The infusion usually runs 12 to 24 hours. Adjust the IV rate based on the dose, mix details, total daily volume, and duration. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: amino acid mixture d / calcium chloride dihydrate / glucose monohydrate / glycine / magnesium chloride hexahydrate / olive oil / potassium chloride / sodium acetate trihydrate / sodium glycerophosphate pentahydrate / soya-bean oil 

Pronounced: uh-MEE-no AS-id MIKS-cher D / KAL-see-um KLOR-ide dye-HIE-drate / GLOO-kose MAH-no-HIE-drate / GLY-seen / mag-NEE-zee-um KLOR-ide HEK-suh-HIE-drate / AH-live OYL / puh-TAS-ee-um KLOR-ide / SOH-dee-um AS-uh-tate try-HIE-drate / SOH-dee-um glahy-ser-foh-fos-feyt pen-tuh-HIE-drate / SOY-uh-been OYL 

Why do we use amino acid mixture d / calcium chloride dihydrate / glucose monohydrate / glycine / magnesium chloride hexahydrate / olive oil / potassium chloride / sodium acetate trihydrate / sodium glycerophosphate pentahydrate / soya-bean oil? 

The combination has many uses in medicine, diet, and pharmacy. It works for things like IV vitamins for people who can’t take food by mouth. It’s also used in drug solutions or fluids that go into the body. It’s used for nutrition needs when eating is hard, hydration and getting electrolytes balanced in medical conditions, and nutrition therapy, with parts that help heal wounds and fix tissues. How it’s used depends on what each patient needs and wants to get better.