Brand Name :
Xywav
Synonyms :
Class :
Sedative and hypnotic
Dosage Forms & Strengths
Oral solution-500mg/ml (calcium oxybate-234mg/ml, magnesium oxybate 96mg/ml, potassium oxybate-13mg/ml, and sodium oxybate-4mg/ml)
4.5
g
Orally
Once a day in the night
Tablet
divided into two doses- 2.25g half strength and 2.25g taken 2.5-4
hours
later
increase up to 1.5g/night at weekly intervals
Twice-nightly regimen:
Initial dose: ≤4.5 g orally in two doses
Maximum dose: ≤9g orally in two doses
Once-nightly regimen:
Initial dose: ≤3 g orally half strength
Maximum dose:6 g orally half strength
Dosage Forms & Strengths
Oral solution-500mg/ml (calcium oxybate-234mg/ml, magnesium oxybate 96mg/ml, potassium oxybate-13mg/ml, and sodium oxybate-4mg/ml)
<7 years: Safety and efficacy not established
≥7 years
<20 kgs: Start with the lower dose
20 to <30kgs:
Initial dose-2g orally/day, divided into two doses
Maintenance dose- increase by 1g orally/night
Maximum dose-6g/day
30 to <45kgs:
Initial dose-3g orally/day, divided into two doses
Maintenance dose-increase by 1g orally/night
Maximum dose- 7.5g/day
>45 kgs:
Initial dose- 4.5g orally/day, divided into two doses
Maintenance dose-increase by 1.5g orally/night
Maximum dose-9g/day
<7 years: Safety and efficacy not established
≥7 years
<20 kgs: Start with the lower dose
20 to <30kgs:
Initial dose-2g orally/day, divided into two doses
Maintenance dose- increase by 1g orally/night
Maximum dose-6g/day
30 to <45kgs:
Initial dose-3g orally/day, divided into two doses
Maintenance dose-increase by 1g orally/night
Maximum dose-7.5g/day
>45 kgs:
Initial dose-4.5g orally/day, divided into two doses
Maintenance dose-increase by 1.5g orally/night
Maximum dose-9g/day
Refer adult dosing
may have an increased CNS depressant effect when combined with oxybate salt products
may have an increased CNS depressant effect when combined with oxybate salt products
may have an increased CNS depressant effect when combined with oxybate salt products
may have an increased CNS depressant effect when combined with oxybate salt products
may have an increased CNS depressant effect when combined with oxybate salt products
may enhance the serum concentration
may increase the CNS depressant effect of CNS Depressants
may diminish the calcium salts excretion
may diminish the calcium salts excretion
may diminish the calcium salts excretion
may diminish the calcium salts excretion
Frequency defined:
Narcolepsy
>10%
Adults
Nausea
Headache
Pediatrics
Headache
Nausea
Vomiting
Enuresis
1-10%
Adults
Anxiety
Dry mouth
Enuresis
Dizziness
Irritability
Tremor
Muscle spasm
Paresthesia
Parasomnia
Pediatrics
Dizziness
Decreased appetite
Idiopathic hypersomnia
>10%
Anxiety
Nausea
Headache
1-10%
Balance disorder
Bruxism
Confusional state
Dry mouth
Fatigue
Fall
Muscle spasm
Snoring
Parasomnia
Tremor
Pregnancy consideration: N/A
Lactation: Insufficient data available
Pregnancy category:
Patient information leaflet
Generic Name: Calcium, magnesium, potassium, and sodium oxybates
Pronounced: [ KAL-see-um, mag-NEE-zee-um, Poe-TAS-ee-um, and-SOE-dee-um-OX-i-bate]
Why do we use Calcium, magnesium, potassium, and sodium oxybates?
It is used to treat cataplexy or to reduce daytime sleepiness caused by narcolepsy and idiopathic hypersomnia.
ADVERTISEMENT
Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
USA – BOSTON
60 Roberts Drive, Suite 313
North Adams, MA 01247
INDIA – PUNE
7, Shree Krishna, 2nd Floor, Opp Kiosk Koffee, Shirole Lane, Off FC Road, Pune 411004, Maharashtra
Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
MASSACHUSETTS – USA
60 Roberts Drive, Suite 313,
North Adams, MA 01247
MAHARASHTRA – INDIA
7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
