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phenobarbital

Brand Name :

Sezaby

Synonyms :

phenobarbital

Class :

Barbiturates, Anti convulsants





No data available for drug.

Actions and Spectrum: 

  • phenobarbital is a barbiturate drug used as an anticonvulsant and sedative for over a century. Its mechanism of action involves enhancing the activity of the brain’s neurotransmitter GABA (gamma-aminobutyric acid). 
  • GABA is an inhibitory neurotransmitter that helps to regulate the excitability of neurons in the brain. When GABA binds to its receptors, it opens channels in the neuron’s cell membrane, allowing negatively charged ions to flow into the cell. This hyperpolarizes the neuron, making it less likely to fire an action potential and transmit a signal. 
  • phenobarbital enhances the activity of GABA by binding to a specific site on GABA-A receptors, which are ionotropic receptors that mediate the effects of GABA. This binding increases the duration of time that the GABA-A receptor channel is open, allowing more chloride ions to enter the neuron and further inhibiting its activity. 
  • Regarding its spectrum of activity, phenobarbital is primarily used as an anticonvulsant to prevent or control seizures. It is particularly effective in treating partial and generalized tonic-clonic seizures but may also be used to treat other seizure types.  
  • phenobarbital is also a sedative and hypnotic and may be used to treat anxiety, insomnia, and other conditions. However, due to its soothing effects, it is generally not recommended for long-term use as a sleep aid or for anxiety unless other treatments have been ineffective. 

DRUG INTERACTION

phenobarbital

&

  • carmellose sodium
  • ibandronic acid
  • cinnarizine and dimenhydrinate
  • ursodeoxycholic acid
  • rhubarb extract/salicylic acid
  • butamirate citrate
  • fumitory
  • taheebo
  • uva ursi
  • vervain
  • coleus
  • coltsfoot
  • crampbark
  • plantain
  • potassium nitrate and silver nitrate
  • gelsemium
  • gentian
  • glucomannan
  • walnut
  • meadowsweet
  • midomafetamine
  • pennyroyal
  • periwinkle
  • betony
  • bitter orange
  • bladderwrack
  • bloodroot
  • emu oil
  • garcinia
  • yellow dock
  • burdock
  • dehydroepiandrosterone
  • aucubin
  • jasmone
  • resacetophenone
  • ecamsule ditriethanolamine
  • feclobuzone
  • fenoprop triethanolamine
  • verdyl acetate
  • caffeic acid
  • cyclamen aldehyde
  • dicetyldimonium chloride
  • wogonin
  • impacarzine
  • laurylpyridinium chloride
  • stepronin
  • matrine
  • sakuranin
  • cannabichromene
  • sandalore
  • sabinene
  • oxypaeoniflora
  • ethylhexyl pelargonate
  • acrylonitrile
  • allyl alcohol
  • dipalmitoylethyl hydroxyethylmonium methosulfate
  • butidrine
  • clothiapine
  • propanediol dicaprylate
  • buchu
  • undecanol
  • enilconazole
  • xymenynic acid
  • angelica
  • nizubaglustat
  • resomelagon
  • ulecaciclib
  • apple cider vinegar
  • bacopa
  • barley grass
  • dandelion
  • deer velvet
  • dolomite
  • bugleweed
  • bupleurum
  • glyceryltrinitrate
  • pociredir
  • asnuciclib
  • actalycabtagene autoleucel
  • butantan–dengue vaccine
  • travoprost/timolol
  • furosemide/potassium chloride
  • amylamine
  • jaborandi
  • patritumab deruxtecan
  • jackfruit
  • sterculia
  • ascorbigen
  • ashitaba
  • androstenetrione
  • andrachne
  • cosibelimab
  • racecadotril
  • neomycin/chlorhexidine
  • octocog alfa
  • cetrimide
  • ispaghula husk
  • polyhexanide
  • octenidine
  • polygeline
  • heparinoid
  • jewelweed
  • boldo
  • anizatrectinib
  • alpinia
  • henbane
  • cynanchum vincetoxicum root and sulfur
  • boditrectinib
  • izumerogant
  • zavondemstat
  • abuta
  • fadogia agrestis
  • fly agaric mushroom
  • meptazinol
  • methoxyflurane
  • tramadol/dexketoprofen
  • betaine/polyhexanide
  • filgotinib
  • inosine acedoben dimepranol
  • alverine citrate
  • hyoscine butylbromide
  • senna+ ispaghula
  • cabbage palm
  • cajeput oil
  • calanus oil
  • calamint
  • canada balsam
  • carnosine
  • alverine citrate/simeticone
  • dihydroartemisinin/piperaquine
  • mebeverine/ispaghula
  • calcipotriol
  • tacalcitol
  • triethyl citrate/ethyl linoleate
  • sodium dilauramidoglutamide lysine
  • fazamorexant
  • avibactam tomilopil and ceftibuten
  • drostanolone
  • tigilanol tiglate
  • isorhynchophylline
  • rhynchophylline
  • crisugabalin
  • epigallocatechin gallate
  • clomocycline
  • corynoxeine
  • isocorynoxeine
  • Culmerciclib
  • Neladenoson
  • ambrein
  • hexylcaine
  • phensuximide
  • resencatinib (investigational)
  • rolusafine
  • pumecitinib
  • arhalofenic acid
  • berdazimer sodium
  • benzquinamide
  • clidinium
  • sulfametopyrazine
  • fulzerasib (Investigational Drug)
  • rovadicitinib (Investigational Drug)
  • Upleganan (Investigational Drug)
  • menthyl ethylamido oxalate
  • quaternium-90 montmorillonite
  • unecritinib (investigational drug)
  • etohexadiol
  • guaiol
  • proximadiol
  • verdinexor
  • sofnobrutinib
  • talbutal
  • ethoxzolamide
  • propiomazine
  • enprofylline
  • phenmetrazine
  • merigolix
  • pralurbactam
  • neracorvir
  • vonifimod
  • apaziquone hydroquinone
  • darizmetinib
  • zandelisib
  • xininurad
  • ritivixibat
  • amiselimod phosphate (investigational drug)
  • emzeltrectinib (investigational drug)
  • ficonalkib
  • cinalukast
  • ulobetasol
  • candoxatril
  • nitrofural
  • acetyldigitoxin
  • bentiromide
  • dextrothyroxine
  • chlorotrianisene
  • remikiren
  • pipobroman
  • vidarabine
  • immune globulin intravenous, human-stwk
  • spermine
  • serine
  • N-acetyl glucosamine
  • valine
  • adenine
  • asparagine
  • citrulline
  • adinazolam
  • interferon alfacon-1
  • interferon alfa-n1
  • felypressin
  • birch triterpenes
  • pyridoxal phosphate
  • technetium Tc-99m arcitumomab
  • beta-alanine
  • dihomo-gamma-linolenic acid
  • urea/hydrocortisone
  • R21/Matrix-M vaccine
  • povidone-iodine (ophthalmic)
  • pheniramine
  • hydrocortisone rectal
  • chloroxylenol/pramoxine/zinc acetate
  • chloroxylenol/pramoxine
  • dextrose/sucrose/vitamin C/zinc sulphate
  • furazolidone/metronidazole/dicyclomine
  • ergocalciferol (vitamin D2)
  • benoxaprofen (discontinued)
  • teicoplanin
  • carbomer
  • chromic chloride / iron (ii) chloride tetrahydrate / potassium iodide / manganese chloride / sodium fluoride / sodium selenite pentahydrate / sodium molybdate dihydrate / zinc chloride/ cupric chloride
  • bufylline
  • lidocaine/prilocaine
  • opium tincture, squill oxymel
  • dibrompropamidine
  • metronidazole/tetracycline/bismuth subsalicylate
  • agnus- castus
  • velaglucerase alfa
  • alendronic acid / colecalciferol
  • bimatoprost / timolol
  • efbemalenograstim alfa
  • dried ferrous sulfate/folic acid
  • dried ferrous sulfate / sodium ascorbate
  • nirogacestat
  • soya-bean oil, medium-chain triglycerides
  • demeclocycline hydrochloride and triamcinolone acetonide
  • fusidic acid / hydrocortisone acetate
  • macrogol
  • storax, benzoin
  • nomegestrol acetate/estradiol
  • flumetasone pivalate/ clioquinol
  • berdazimer topical (Pending FDA Approval)
  • buflomedil
  • butobarbital
  • andexanet alfa
  • methoxypolyethylene glycol-epoetin beta
  • viscum abietis
  • pramoxine vaginal
  • bupivacaine implant
  • cromolyn sodium, inhaled
  • pneumococcal vaccine 20-valent
  • bimatoprost ophthalmic implant
  • tick-borne encephalitis vaccine
  • chloroprocaine ophthalmic
  • travoprost intraocular implant (Pending FDA approval)
  • typhoid polysaccharide vaccine
  • sodium phosphate rectal
  • human papillomavirus vaccine, nonavalent
  • peanut immunotherapy epicutaneous (FDA approval pending)
  • cromolyn sodium, intranasal
  • red blood cells(Blood component)
  • oral mucoadhesive
  • clindamycin vaginal
  • whole blood (Blood Component)
  • fibrinogen/thrombin
  • levothyroxine/liothyronine
  • ipratropium intranasal
  • metronidazole vaginal
  • cyamemazine
  • brinase
  • reviparin
  • ulinastatin
  • saruplase
  • acepromazine
  • emylcamate
  • methionine
  • amino acids and electrolytes in dextrose with calcium
  • slippery elm
  • camostat
  • hemoglobin crosfumaril
  • moperone
  • chlormidazole
  • brilaroxazine
  • palopegteriparatide
  • diazepam buccal
  • benegrastim (pending for FDA approval)
  • COVID-19 vaccine, adjuvanted-Novavax
  • vestronidase alfa-vjbk
  • tebipenem (Pending FDA Approval)
  • tislelizumab (Pending FDA Approval)
  • zolbetuximab (Pending FDA Approval)
  • zoliflodacin (pending FDA approval)
  • zibotentan and dapagliflozin
  • fluorine F18 DCFPyL
  • debamestrocel
  • givinostat
  • amubarvimab and romlusevimab(Pending FDA Approval)
  • sabizabulin(Pending FDA approval)
  • fexapotide(Phase 3 Clinical trial)
  • diatrizoic acid
  • drotaverine
  • diethyl phthalate
  • enclomiphene
  • epalrestat
  • ethamsylate
  • flupirtine
  • imidurea
  • sodium glycolate
  • feracrylum
  • ethacridine
  • furazolidone/metronidazole
  • ozagrel hydrochloride
  • leptazol
  • l-glutamic acid /vitamin B complex
  • etizolam
  • etizolam/propranolol
  • ethoheptazine citrate
  • etophylline and theophylline
  • etophylline
  • finger millet
  • drotaverine/mefenamic acid
  • dichloroxylenol
  • pneumococcal 7-valent vaccine
  • diclofenac and metaxalone
  • dipivefrin ophthalmic
  • enbucrilate
  • potassium citrate and citric acid
  • potassium gluconate
  • aclarubicin
  • alfuzosin/dutasteride
  • adrenochrome monosemicarbazone
  • selenium sulfide topical
  • sertaconazole
  • amorolfine cream
  • amsacrine
  • amylmetacresol
  • sulfonated phenolics in aqueous solution
  • technetium Tc-99m sulfur colloid
  • raltitrexed
  • romiplostim
  • acediasulfone
  • azulene
  • acebrophylline
  • clonazepam/escitalopram oxalate
  • allylestrenol
  • andrographolide
  • artemotil
  • technetium Tc-99m sestamibi
  • rubidium Rb-82
  • somapacitan
  • sodium sulfate, magnesium sulfate and potassium sulfate
  • almitrine
  • gramicidin
  • nikethamide
  • technetium Tc-99m sodium pertechnetate
  • betiatide
  • prilocaine/epinephrine
  • amlexanox
  • acetaminophen/salicylamide/phenyltoloxamine
  • neomycin topical
  • zilucoplan
  • antazoline and xylometazoline
  • toripalimab
  • iron isomaltoside
  • meningococcal A C Y and W polysaccharide tetanus toxoid conjugate vaccine
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • tetradecyl Sulfuric Acid
  • benzoyl peroxide, clindamycin phosphate, adapalene
  • ethylephedrine
  • actarit
  • pyrantel tartrate
  • tenofovir disoproxil fumarate or tenofovir DF
  • melitracen
  • amitriptylinoxide(Phase 4 Clinical Trials)
  • threonine
  • ditiocarb zinc
  • epicriptine
  • levallorphan
  • kinetin
  • laurocapram
  • pentagastrin
  • parthenolide
  • nicoboxil
  • protionamide
  • prulifloxacin
  • proscillaridin
  • tizanidine and rofecoxib
  • tolnaftate, gentamicin, chinoform and betamethasone valerate
  • pine bark extract
  • pipenzolate methylbromide
  • bephenium hydroxynaphthoate
  • niclosamide
  • pyrvinium
  • pipenzolate methylbromide/phenobarbitone
  • piracetam/ginkgo biloba/vinpocetine
  • benzyl benzoate/disulfiram
  • benzyl benzoate
  • loperamide/simethicone
  • piroctone olamine
  • sodium fusidate
  • piroxicam topical/capsaicin/menthol/methyl salicylate
  • sodium metabisulfite
  • sodium lauryl sulfate
  • taspoglutide
  • glyclopyramide
  • tolnaftate, gentamicin, iodochlorohydroxyquinoline, chlorocresol, betamethasone valerate
  • serratiopeptidase
  • sodium antimony gluconate
  • triamterene / benzthiazide
  • tribenoside / lidocaine
  • triclocarban
  • triprolidine/dextromethorphan  
  • vitamins/minerals/omega-3 Fatty acids
  • soyabean oil
  • sucralfate/oxethazaine
  • sucralfate/tinidazole/povidone iodine
  • sodium cromoglycate
  • aloe vera/liquid paraffin/white soft paraffin
  • aloe vera/jojoba oil/vitamin E
  • allantoin/triclosan/vitamin e/zinc oxide
  • alpha-Lipoic acid/minerals/multivitamins
  • alprazolam/paracetamol
  • alprazolam/melatonin
  • azithromycin/ambroxol
  • atorvastatin/clopidogrel/aspirin
  • aceclofenac, paracetamol and serratiopeptidase
  • alfacalcidol, vitamin B-complex, minerals and antioxidants
  • alpha- lipoic acid, vitamin b complex and vitamin c
  • alpha-galactosidase and simethicone
  • alpha-galactosidase, amylase, proteases, lipase and lactase
  • amikacin and cefepime
  • aminophylline, ephedrine and phenobarbitone
  • artesunate, sulphadoxine and pyrimethamine
  • finasteride/tamsulosin
  • flavoxate/ofloxacin
  • fenofibrate/metformin
  • lignocaine, hydrocortisone topical and allantoin
  • linoleic acid and sodium lactate
  • troxerutin
  • meclizine/nicotinic acid
  • mecobalamin/ginkgo Biloba
  • spirulina
  • loperamide and furazolidone
  • ketoconazole/cetrimide
  • ketoconazole/zinc pyrithione
  • lercanidipine/atenolol
  • levocetirizine/montelukast/ambroxol
  • levarterenol
  • levocetirizine/phenylpropanolamine 
  • indapamide/amlodipine
  • itopride/methyl polysiloxane
  • mebendazole/levamisole
  • eberconazole/mometasone
  • gliclazide/metformin/pioglitazone
  • fluconazole/tinidazole
  • haemocoagulase
  • halometasone
  • hesperidin
  • imipramine/chlordiazepoxide
  • idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
  • mecobalamin and piracetam
  • mesterolone
  • mosapride and pantoprazole
  • atorvastatin, co enzyme q10, vitamin e, zinc, and selenium
  • azithromycin and benzalkonium chloride
  • beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12
  • alpha-galactosidase
  • aloe vera gel/vitamin e/lactic acid
  • aloe vera gel/jojoba/vitamin e/glycerine
  • famotidine and domperidone
  • faropenem medoxomil
  • nedosiran
  • fluconazole/ornidazole/azithromycin
  • ebastine/montelukast
  • eberconazole
  • dienogest/estradiol valerate
  • ambroxol/salbutamol
  • benzoic acid/salicylic acid/ichthammol/ triamcinolone acetonide
  • desloratadine/ambroxol
  • dexibuprofen/paracetamol
  • atorvastatin/ramipril
  • diastase
  • diastase and simethicone
  • diazepam and propranolol
  • dexrabeprazole / domperidone
  • dexrabeprazole
  • dexketoprofen /paracetamol
  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel oral/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • elamipretide (Pending FDA approval)
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • tepotinib 
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine, live
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitinib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
phenobarbital + 

Severity : Monitor Closely
may enhance the serum concentration of CYP3A4 inhibitors
Severity : Monitor Closely
may have an increased CNS depressant effect when combined with CNS depressants

ethinyl estradiol

may decrease the levels of serum concentration of hormonal contraceptives

etonogestrel

may decrease the levels of serum concentration of hormonal contraceptives

ethinylestradiol

may decrease the levels of serum concentration of hormonal contraceptives

ethynodiol diacetate

may decrease the levels of serum concentration of hormonal contraceptives

acenocoumarol

may increase the metabolism of vitamin K antagonists

fluindione

may increase the metabolism of vitamin K antagonists

phenindione

may increase the metabolism of vitamin K antagonists

phylloquinone

may increase the metabolism of vitamin K antagonists

warfarin

may increase the metabolism of vitamin K antagonists

remifentanil

may have an increased CNS depressive effect when combined with opioid agonists

hydrocodone/pseudoephedrine

may have an increased CNS depressive effect when combined with opioid agonists

codeine

may have an increased CNS depressive effect when combined with opioid agonists

morphine

may have an increased CNS depressive effect when combined with opioid agonists

abiraterone 

may diminish the serum concentration of CYP3A4 Inducers

acalabrutinib 

may diminish the serum concentration of CYP3A4 Inducers

alfentanil 

may diminish the serum concentration of CYP3A4 Inducers

apixaban 

may diminish the serum concentration of CYP3A4 Inducers

aripiprazole 

may diminish the serum concentration of CYP3A4 Inducers

atazanavir 

may diminish the serum concentration of PHENobarbital

atogepant 

may diminish the serum concentration of CYP3A4 Inducers

belumosudil 

may diminish the serum concentration of CYP3A4 Inducers

buprenorphine 

may increase the CNS depressant effect of Phenobarbital

canagliflozin 

may diminish the serum concentration of PHENobarbital

clarithromycin 

may increase serum concentrations of CYP3A4 Inducers

clozapine 

may diminish the serum concentration of CYP3A4 Inducers

codeine 

may increase the CNS depressant effect of PHENobarbital

dasatinib 

may diminish the serum concentration of CYP3A4 Inducers

dexamethasone 

may diminish the serum concentration of CYP3A4 Inducers

dexmedetomidine 

may increase the CNS depressant effect of CNS Depressants

enzalutamide 

may diminish serum concentrations of CYP3A4 Inducers

etoposide 

may diminish the serum concentration of CYP3A4 Inducers

felbamate 

may diminish the serum concentration of phenobarbital

tramadol 

phenobarbital: they may increase the CNS depressant effect of tramadol

protriptyline

may enhance the metabolism when combined with tricyclic antidepressants

zuranolone

may enhance the metabolism when combined with tricyclic antidepressants

5-htp

may enhance the metabolism when combined with tricyclic antidepressants

desvenlafaxine

may enhance the metabolism when combined with tricyclic antidepressants

tranylcypromine

may enhance the metabolism when combined with tricyclic antidepressants

isocarboxazid

may enhance the metabolism when combined with tricyclic antidepressants

epcoritamab

may increase the serum concentration of each other when combined

adagrasib

may increase the serum concentration of each other when combined

imiquimod topical

may increase the serum concentration of each other when combined

fluorouracil topical

may increase the serum concentration of each other when combined

peginterferon alfa-2b

may increase the serum concentration of each other when combined

medroxyprogesterone

may diminish the concentration of serum when combined with hormonal contraceptives

megestrol

may diminish the concentration of serum when combined with hormonal contraceptives

drospirenone

may diminish the concentration of serum when combined with hormonal contraceptives

dydrogesterone

may diminish the concentration of serum when combined with hormonal contraceptives

nabilone

may diminish the concentration of serum when combined with cannabinoid products

cannabidiol

may diminish the concentration of serum when combined with cannabinoid products

levonorgestrel

CYP3A4 Inducers: they may diminish the serum concentration of hormonal contraceptives

lynestrenol

CYP3A4 Inducers: they may diminish the serum concentration of hormonal contraceptives

hydroxyzine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

levocabastine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

mepyramine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

acrivastine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

alimemazine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

hydrocodone and homatropine

may have an increased CNS depressant effect when combined with opioid agonists

dezocine

may have an increased CNS depressant effect when combined with opioid agonists

buprenorphine

may have an increased CNS depressant effect when combined with opioid agonists

trimebutine

may have an increased CNS depressant effect when combined with opioid agonists

dextropropoxyphene

may have an increased CNS depressant effect when combined with opioid agonists

desogestrel

may diminish the serum concentration when combined with hormonal contraceptives

mestranol

may diminish the serum concentration when combined with hormonal contraceptives

ulipristal

may diminish the serum concentration when combined with hormonal contraceptives

imipramine

may enhance the metabolism when combined with tricyclic antidepressants

protriptyline

may enhance the metabolism when combined with tricyclic antidepressants

trimipramine

may enhance the metabolism when combined with tricyclic antidepressants

indoramin

may increase the action of CNS depressants inducing CNS depression

bunazosin (Not available in the United States)

may increase the action of CNS depressants inducing CNS depression

terazosin

may increase the action of CNS depressants inducing CNS depression

prazosin

may increase the action of CNS depressants inducing CNS depression

alfuzosin

may increase the action of CNS depressants inducing CNS depression

tropisetron

May reduce the plasma concentration of tropisetron

hydroxyzine

hydroxyzine may enhance the CNS depressant effect of CNS depressants

lemborexant

lemborexant may enhance the CNS depressant effect of CNS depressants

methotrimeprazine

CNS depressants may enhance the CNS depressant effect of methotrimeprazine

clofazimine 

may increase the serum concentration of CYP3A4 substrates

buprenorphine 

may increase the CNS depressant effect

daridorexant 

may enhance the CNS depressant effect

dexmedetomidine 

may enhance the CNS depressant effect

droperidol 

may enhance the CNS depressant effect

zolpidem 

may enhance the CNS depressant effect

doravirine 

it decreases by affecting the hepatic enzyme CYP3A4 metabolism

chlormethiazole 

may increase the CNS depressant effect

hydroxyzine 

may increase the CNS depressant effect

nalbuphine 

may increase the depressant effect of opioid agonists

tranylcypromine

may increase the metabolism of tricyclic antidepressants

dextromethorphan/bupropion

may increase the metabolism of tricyclic antidepressants

amitriptyline

may increase the metabolism of tricyclic antidepressants

brexanolone

may increase the metabolism of tricyclic antidepressants

doxepin

may increase the metabolism of tricyclic antidepressants

protriptyline

may increase the metabolism of tricyclic antidepressants

paregoric 

may increase the CNS depressant effect of opioid agonists

rifampin 

may diminish the serum concentration

levorphanol 

may increase the CNS depressant effect

tapentadol 

may increase the CNS depressant of opioid agonists

etomidate 

may increase the risk or severity of hypertension when combined

acalabrutinib 

may diminish the serum concentration

budesonide and formoterol (inhalation) 

may enhance the serum concentration of CYP3A4 inhibitor

buprenorphine and naloxone 

may increase the CNS depressant effect of CNS depressants

abiraterone 

may diminish the serum concentration of CYP3A4 inducers

clarithromycin 

may enhance serum concentrations of CYP3A4 inducers

dasatinib 

may diminish the serum concentration of CYP3A4 inducers

dexamethasone 

may diminish the serum concentration of CYP3A4 inducers

flunitrazepam 

may have an increased CNS depressant effect when combined with flunitrazepam

nifedipine 

may decrease the serum concentration when combined with CYP3A4 Inducers (Strong)

lemborexant 

may have an increased CNS depressive effect when combined with CNS depressants

methotrimeprazine 

may have an increased CNS depressive effect when combined with methotrimeprazine

oxycodone 

may have an increased CNS depressive effect when combined with oxycodone

suvorexant 

may have an increased CNS depressive effect when combined with suvorexant

sparsentan 

may increase or decrease the activity of this enzyme when combined with sparsentan

alfentanil 

may diminish the serum concentration when combined with alfentanil

apixaban 

may diminish the serum concentration when combined with apixaban

aripiprazole 

may diminish the serum concentration when combined with aripiprazole

aripiprazole lauroxil 

may diminish serum concentrations when combined with aripiprazole lauroxil

atogepant 

may diminish the serum concentration when combined with atogepant

belumosudil 

may diminish the serum concentration when combined with belumosudil

brexpiprazole 

may diminish the serum concentration when combined with brexpiprazole

ubrogepant 

may diminish the serum concentration when combined with ubrogepant

fenfluramine 

may diminish the serum concentration when combined with fenfluramine

calcium, magnesium, potassium and sodium oxybate 

may have an increased CNS depressant effect when combined with oxybate salt products

ropeginterferon alfa 2b 

may have an increasingly adverse effect when combined with ropeginterferon alfa-2b

remifentanil

may have an increased CNS depressant effect when combined with opioid agonists

hydrocodone/pseudoephedrine

may have an increased CNS depressant effect when combined with opioid agonists

codeine

may have an increased CNS depressant effect when combined with opioid agonists

morphine

may have an increased CNS depressant effect when combined with opioid agonists

methohexital 

may increase the CNS depressant effect of CNS depressants

cholestyramine 

they may diminish the serum concentration when combined with rosiglitazone

artemether/lumefantrine 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

atazanavir 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

cariprazine 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

cobimetinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

darunavir 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

dienogest/estradiol valerate 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

elbasvir/grazoprevir 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism

rilpivirine 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

vandetanib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

voriconazole 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

nalmefene 

nalmefene: they may decrease the therapeutic effect of Opioid Agonists

brivaracetam 

CYP2C19 Inducers: they may diminish the serum concentration of brivaracetam

cabozantinib 

cabozantinib :they may diminish the serum concentration of CYP3A4 Inducers

clopidogrel 

clopidogrel: they may enhance serum concentrations of CYP2C19 Inducers

cyclosporine 

cyclosporin: they may diminish the serum concentration of CYP3A4 Inducers

diltiazem 

diltiazem: they may diminish the serum concentration of CYP3A4 Inducers

enzalutamide 

enzalutamide: they may diminish serum concentrations of the active metabolites of CYP3A4 inducers

eravacycline 

CYP3A4 inducers: they may diminish the serum concentration of eravacycline

erlotinib 

erlotinib: they may diminish the serum concentration of CYP3A4 inducers

etoposide 

etoposide: they may diminish the serum concentration of CYP3A4 inducers

exemestane 

exemestane: they may diminish the serum concentration of CYP3A4 Inducers

felodipine 

felodipine: they may diminish the serum concentration of CYP3A4 Inducers

ganaxolone 

CYP3A4 inducers: they may diminish the serum concentration of ganaxolone

buprenorphine buccal 

may increase the CNS depressant effect of Buprenorphine

buprenorphine buccal 

may increase the CNS depressant effect of Buprenorphine

sotorasib 

may diminish the serum concentration of zanubrutnib

drospirenone/ethinyl estradiol/levomefolate 

may diminish the serum concentration of Hormonal Contraceptives

buprenorphine,long-acting injection 

may increase the CNS depressant effect of Buprenorphine

voxelotor 

may diminish the serum concentration of Voxelotor

brigatinib 

brigatinib: they may diminish the serum concentration of CYP3A4 Inducers

daclatasvir 

daclatasvir: they may diminish the serum concentration of CYP3A4 Inducers

guanfacine 

guanfacine: they may diminish the serum concentration of CYP3A4 Inducers

larotrectinib 

CYP3A4 Inducers: they may diminish the serum concentration of larotrectinib

lefamulin 

lefamulin: they may diminish the serum concentration of CYP3A4 Inducers

lorlatinib 

lorlatinib: they may increase the hepatotoxic effect of CYP3A4 Inducers

lurasidone 

lurasidone: they may diminish the serum concentration of CYP3A4 Inducers

maraviroc 

maraviroc: they may diminish the serum concentration of CYP3A4 Inducers

mitapivat 

mitapivat: they may diminish the serum concentration of CYP3A4 Inducers

perampanel 

perampanel: they may diminish the serum concentration of CYP3A4 Inducers

pirtobrutinib 

pirtobrutinib: they may diminish the serum concentration of CYP3A4 Inducers

praziquantel 

praziquantel: they may diminish the serum concentration of CYP3A4 Inducers

ripretinib 

ripretinib: they may diminish the serum concentration of CYP3A4 Inducers

zanubrutinib 

zanubrutinib: they may diminish the serum concentration of CYP3A4 Inducers

methylprednisolone 

may diminish the concentration of serum when combined with methylprednisolone

etonogestrel 

may diminish the serum concentration of Hormonal Contraceptives

etonogestrel/ethinyl estradiol 

may diminish the serum concentration of Hormonal Contraceptives

medroxyprogesterone

may diminish the concentration of serum when combined with hormonal contraceptives

megestrol

may diminish the concentration of serum when combined with hormonal contraceptives

drospirenone

may diminish the concentration of serum when combined with hormonal contraceptives

dydrogesterone

may diminish the concentration of serum when combined with hormonal contraceptives

indinavir 

may diminish the concentration of serum when combined with indinavir

ketazolam 

may increase the risk of CNS depression when combined with 1,2-Benzodiazepine

dexmethylphenidate 

dexmedetomidine: they may increase the CNS depressant effect of CNS Depressants

oxolamine 

oxolamine: they may increase the CNS depressant effect of CNS Depressants

ranolazine 

ranolazine: they may enhance the serum concentration of CYP3A4 Inducers

sirolimus 

sirolimus: they may enhance the serum concentration of CYP3A4 Inducers

triazolam 

triazolam: they may enhance the serum concentration of CYP3A4 Inducers

desogestrel

may diminish the serum concentration when combined with hormonal contraceptives

mestranol

may diminish the serum concentration when combined with hormonal contraceptives

ulipristal

may diminish the serum concentration when combined with hormonal contraceptives

clozapine 

clozapine: they may increase the CNS depressant effect of CNS Depressants

nitrazepam 

nitrazepam: they may increase the CNS depressant effect of CNS Depressants

obinutuzumab 

obinutuzumab: they may increase the CNS depressant effect of CNS Depressants

secretin 

secretin: they may increase the CNS depressant effect of CNS Depressants

cimetropium 

cimetropium: they may increase the CNS depressant effect of CNS Depressants

guanethidine 

guanethidine: they may increase the CNS depressant effect of CNS Depressants

potassium phosphate 

potassium phosphate: they may increase the CNS depressant effect of CNS Depressants

amisulpride 

amisulpride: they may increase the CNS depressant effect of CNS Depressants

tiotropium 

tiotropium: they may increase the CNS depressant effect of CNS Depressants

nitroglycerin 

nitroglycerin: they may increase the CNS depressant effect of CNS Depressants

ramosetron 

ramosetron: they may increase the CNS depressant effect of CNS Depressants

norethisterone 

decrease in activity of norethisterone may be observed when taken with phenobarbital

cocaine 

cocaine: they may increase the CNS depressant effect of CNS Depressants

linezolid 

linezolid: they may increase the CNS depressant effect of CNS Depressants

oxychlorosene 

oxychlorosene: they may increase the CNS depressant effect of CNS Depressants

epcoritamab

may diminish the serum concentration of each other when combined

adagrasib

may diminish the serum concentration of each other when combined

imiquimod topical

may diminish the serum concentration of each other when combined

fluorouracil topical

may diminish the serum concentration of each other when combined

peginterferon alfa-2b

may diminish the serum concentration of each other when combined

abiraterone

may diminish the serum concentration of each other when combined

cyproterone

may diminish the serum concentration of each other when combined

darolutamide

may diminish the serum concentration of each other when combined

dienogest/estradiol valerate

may diminish the serum concentration of each other when combined

flutamide

may diminish the serum concentration of each other when combined

abciximab 

abciximab: it may decrease the excretion rate of abacavir CNS depressant

propoxiphene hydrochloride 

combining CNS depressants with propoxyphene may result in an additive CNS depression

rimonabant 

rimonabant has the potential to intensify the effects of additional central nervous system depressants, including alcohol, benzodiazepines, and opioids, resulting in heightened sedation or respiratory depression

benorilate 

benorilate: it may increase the risk of CNS depression

benoxaprofen 

benoxaprofen: it may increase the risk of CNS depression

alpelisib 

alpelisib: it may increase the risk of CNS depression

alogliptin 

alogliptin: it may increase the risk of CNS depression

albendazole 

albendazole: it may increase the risk of CNS depression

acyclovir 

acyclovir: it may increase the risk of CNS depression

benzydamine 

benzydamine: it may increase the risk of CNS depression

cannabidiol 

cannabidiol: it may increase the risk of CNS depression

capsaicin 

capsaicin: it may increase the risk of CNS depression

captopril 

captopril: it may increase the risk of CNS depression

bupivacaine 

bupivacaine: it may increase the risk of methemoglobinemia agents

benzyl alcohol 

benzyl alcohol: it may increase the risk of methemoglobinemia agents

capecitabine 

capecitabine: it may increase the risk of methemoglobinemia agents

capsaicin 

capsaicin: it may increase the risk of methemoglobinemia agents

diphenhydramine 

diphenhydramine: it may increase the risk of methemoglobinemia agents

dyclonine 

dyclonine: it may increase the risk of methemoglobinemia agents

estetrol 

estetrol: it may increase the risk of methemoglobinemia agents

furosemide 

furosemide: it may increase the risk of methemoglobinemia agents

levobupivacaine 

levobupivacaine: it may increase the risk of methemoglobinemia agents

lidocaine 

lidocaine: it may increase the risk of methemoglobinemia agents

mepivacaine 

mepivacaine: it may increase the risk of methemoglobinemia agents

nedaplatin 

nedaplatin: it may increase the risk of methemoglobinemia agents

acemetacin 

acemetacin: it may increase the risk of methemoglobinemia agents

acetazolamide 

acetazolamide: it may increase the risk of methemoglobinemia agents

acetylsalicylic acid 

acetylsalicyclic acid: it may increase the risk of methemoglobinemia agents

amiloride 

amiloride: it may increase the risk of methemoglobinemia agents

amitriptyline 

amitriptyline: it may increase the risk of methemoglobinemia agents

ammonium chloride 

ammonium chloride: it may increase the risk of methemoglobinemia agents

benorilate 

benorilate: it may increase the risk of methemoglobinemia agents

benserazide 

benserazide: it may increase the risk of methemoglobinemia agents

benzatropine 

benzatropine: it may increase the risk of methemoglobinemia agents

bepotastine 

bepotastine: it may increase the risk of methemoglobinemia agents

bismuth subgallate 

bismuth subgallate: it may increase the risk of methemoglobinemia agents

bisoxatin 

bisoxatin: it may increase the risk of methemoglobinemia agents

amobarbital 

amobarbital: it may decreased the serum concentration of CNS depressants

pheneticillin 

pheneticillin: it may increase the risk of methemoglobinemia associated agents

cinchocaine 

cinchocaine: it may increase the risk of methemoglobinemia associated agents

doxycycline 

doxycycline: it may increase the risk of methemoglobinemia associated agents

enoxacin 

enoxacin: it may increase the risk of methemoglobinemia associated agents

eravacycline 

eravacycline: it may increase the risk of methemoglobinemia associated agents

moricizine 

moricizine: it may increase the risk of methemoglobinemia associated agents

oxybuprocaine 

oxybuprocaine: it may increase the risk of methemoglobinemia associated agents

piperazine 

piperazine: it may increase the risk of methemoglobinemia associated agents

promazine 

promazine: it may increase the risk of methemoglobinemia associated agents

spirapril 

spirapril: it may increase the risk of methemoglobinemia associated agents

carvedilol 

carvedilol: it may increase the risk of methemoglobinemia associated agents

adagrasib 

may decrease the serum concentration of CYP3A4 Inducers

asunaprevir 

may decrease the serum concentration of CYP3A4 Inducers

avacopan 

may decrease the serum concentration of CYP3A4 Inducers

avanafil 

may decrease the serum concentration of CYP3A4 Inducers

avapritinib 

may decrease the serum concentration of CYP3A4 Inducers

azelastine 

may increase the CNS depressant effect of CNS Depressants

lumateperone 

It may diminish the effect when combined with lumateperone by affecting CYP3A4 metabolism

ribavirin

may diminish the concentration of serum when combined with antihepaciviral products

diphenoxylate/atropine

may increase the harmful effects of CNS depressants

phenobarbital

may increase the harmful effects of CNS depressants

apomorphine

may increase the harmful effects of CNS depressants

flurazepam

may increase the harmful effects of CNS depressants

perphenazine

may increase the harmful effects of CNS depressants

alpelisib

when both drugs are combined, there may be a decreased level of serum concentration of alpelisib   

abemaciclib

when both drugs are combined, there may be a reduced effect of abemaciclib by affecting hepatic or intestinal enzyme cyp3a4 metabolism

ixazomib

phenobarbital decreases the effect of ixazomib by altering intestinal/hepatic CYP3A4 enzyme metabolism

fedratinib

phenobarbital decreases the effect of fedratinib by altering the intestinal/hepatic CYP3A4 enzyme metabolism

azelastine

it increases the effect of CNS depressants

bromperidol

it increases the effect of CNS depressants

kratom

it increases the effect of CNS depressants

olopatadine

it increases the effect of CNS depressants

orphenadrine

CNS depressants increase the effect of orphenadrine

oxomemazine

it increases the effect of CNS depressants

paraldehyde

CNS depressants increase the effect of paraldehyde

bromeperidol

it increases the effect of CNS depressants

bromeperidol 

may increase the CNS depressant effect

thalidomide 

may increase the CNS depressant effect

olopatadine 

may increase the CNS depressant effect

fexinidazole 

it increases the concentration of CYP3A4 substrates in the serum

fusidic acid 

it increases the concentration of CYP3A4 substrates in serum

edoxaban 

may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter

doravirine 

they decrease the concentration of doravirine in the serum

eluxadoline 

may increase the constipation effect of opioid agonist

kratom 

may increase the CNS depressant effect

flunarizine 

CNS depressants increase the effect of flunarizine

orphenadrine 

CNS depressants increase the effect of orphenadrine

oxomemazine 

it increases the effect of CNS depressants

paraldehyde 

CNS depressants increase the CNS depressing effect of paraldehyde

nirmatelvir/ritonavir 

may diminish the serum concentration

hemin 

may reduce the therapeutic effect of hemin

ledipasvir/sofosbuvir 

may decrease the serum concentration

nisoldipine 

may diminish the serum concentration

rilpivirine 

they decrease the concentration of rilpivirine

azelastine/fluticasone intranasal 

may increase the CNS depressant effect

macimorelin 

may decrease the serum concentration of macimorelin

avapritinib 

may enhance the serum concentration

lenacapavir 

may decrease the serum concentration of lenacapavir

buprenorphine 

they decrease the concentration of buprenorphine in the serum

activated charcoal 

may decrease the serum concentration of activated charcoal

abemaciclib 

may reduce the level of serum concentration of abemaciclib

methyldopa/hydrochlorothiazide 

may increase the hypotensive effect of blood pressure-lowering agents

adagrasib 

may diminish the serum concentration of CYP3A4 inducers

alpelisib 

may diminish the serum concentration of CYP3A4 inducers

apremilast 

may diminish the serum concentration of CYP3A4 inducers

asunaprevir 

may diminish the serum concentration of CYP3A4 inducers

avanafil 

may diminish the serum concentration of CYP3A4 inducers

bedaquiline 

may diminish serum concentrations of CYP3A4 inducers

bortezomib 

may diminish the serum concentration of CYP3A4 inducers

deflazacort 

may diminish serum concentrations of CYP3A4 inducers

glasdegib 

they decrease the concentration of glasdegib in the serum

infigratinib 

they decrease the concentration of active metabolites of infigratinib in the serum

elbasvir/​grazoprevir 

may enhance the serum concentration of elbasvir/grazoprevir

flibanserin 

may increase the CNS depressant effect of flibanserin

buspirone 

it increases the concentration of CYP3A4 substrates in the serum

tolvaptan 

may diminish the serum concentration when combined with tolvaptan

abemaciclib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

acalabrutinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

apixaban 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

bivalirudin 

It may diminish the effect when combined with phenobarbital by enhancing metabolism

bosutinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

brigatinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

cabozantinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

capmatinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

ceritinib 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

cobicistat 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

dronedarone 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

deflazacort 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

elacestrant 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

everolimus 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

flurazepam 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

tetracycline 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

ulipristal 

It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4

abrocitinib 

abrocitinib: they may diminish the serum concentration of CYP2C19 Inducers

capmatinib 

CYP3A4 Inducers: they may diminish the serum concentration of capmatinib

ceritinib 

ceritinib: they may diminish the serum concentration of CYP3A4 Inducers

crizotinib 

crizotinib: they may diminish the serum concentration of CYP3A4 Inducers

duvelisib 

duvelisib: they may diminish the serum concentration of CYP3A4 Inducers

avacopan 

The serum concentration of Avacopan may be decreased by strong CYP3A4 inducers

lurbinectedin 

they decrease the concentration of lurbinectedin in the serum

lemborexant 

may diminish the concentration of serum when combined with lemborexant

pacritinib 

may enhance the concentration of serum when combined with CYP3A4 substrates

treosulfan 

may enhance the concentration of serum when combined with CYP3A4 substrates

naxitamab 

naxitinib: they may diminish the serum concentration of CYP3A4 Inducers

bosutinib 

bosutinib: they may diminish the serum concentration of CYP3A4 Inducers

cariprazine 

cariprazine: they may diminish the serum concentration of CYP3A4 Inducers

cobimetinib 

cobimetinib: they may diminish the serum concentration of CYP3A4 Inducers

daridorexant 

daridorexant: they may diminish the serum concentration of CYP3A4 Inducers

elacestrant 

CYP3A4 Inducers: they may diminish the serum concentration of elacestrant

fedratinib 

fedratinib: they may diminish the serum concentration of CYP3A4 Inducers

finerenone (Rx) 

finerenone: they may diminish the serum concentration of CYP3A4 Inducers

flibanserin 

flibanserin: they may diminish the serum concentration of CYP3A4 Inducers

ibrexafungerp 

ibrexafungerp: they may diminish the serum concentration of CYP3A4 Inducers

ivabradine 

ivabradine: they may diminish the serum concentration of CYP3A4 Inducers

leniolisib 

leniolisib: they may diminish the serum concentration of CYP3A4 Inducers

mavacamten 

mavacamten: they may diminish the serum concentration of CYP3A4 Inducers

neratinib 

neratinib: they may diminish the serum concentration of CYP3A4 Inducers

olaparib 

olaparib: they may diminish the serum concentration of CYP3A4 Inducers

olutasidenib 

olutasidenib: they may diminish the serum concentration of CYP3A4 Inducers

omaveloxolone 

omaveloxolone: they may diminish the serum concentration of CYP3A4 Inducers

pemigatinib 

pemigatinib: they may diminish the serum concentration of CYP3A4 Inducers

rimegepant 

rimegepant: they may diminish the serum concentration of CYP3A4 Inducers

selumetinib 

selumetinib: they may diminish the serum concentration of CYP3A4 Inducers

sertraline 

sertraline: they may diminish the serum concentration of CYP3A4 Inducers

tazemetostat 

tazemetostat: they may diminish the serum concentration of CYP3A4 Inducers

ulipristal 

ulipristal: they may diminish the serum concentration of CYP3A4 Inducers

venetoclax 

venetoclax: they may diminish the serum concentration of CYP3A4 Inducers

voclosporin 

voclosporin: they may diminish the serum concentration of CYP3A4 Inducers

vonoprazan fumarate 

vonoprazan fumarate: they may enhance the serum concentration of CYP3A4 Inducers

vorapaxar 

vorapaxar: they may diminish the serum concentration of CYP3A4 Inducers

isavuconazonium sulfate 

may diminish the concentration of serum when combined with isavuconazonium sulfate

macitentan and tadalafil 

may diminish the serum concentration when combined

ribavirin

may diminish the concentration of serum when combined with antihepaciviral products

axitinib 

may diminish the concentration of serum when combined with axitinib

dasabuvir 

may diminish the concentration of serum when combined with dasabuvir

entrectinib 

may diminish the concentration of serum when combined with entrectinib

tamoxifen 

they decrease the concentration of active metabolites of tamoxifen in serum

olopatadine intranasal 

olopatadine (Nasal): they may increase the CNS depressant effect of CNS Depressants

azelaic acid 

azelaic acid: they may increase the CNS depressant effect of CNS Depressants

ipratropium 

ipratropium: they may increase the CNS depressant effect of CNS Depressants

levosalbutamol 

levosalbutamol: they may increase the CNS depressant effect of CNS Depressants

naltrexone 

naltrexone: they may increase the CNS depressant effect of CNS Depressants

furosemide 

furosemide: it may increase the CNS depressant effect of CNS Depressants

aclidinium 

aclidinium: they may increase the CNS depressant effect of CNS Depressants

mequitazine 

mequitazine: they may increase the CNS depressant effect of CNS Depressants

glycopyrrolate 

glycopyrrolate: they may increase the CNS depressant effect of CNS Depressants

chlorthalidone 

chlorthalidone: they may increase the CNS depressant effect of CNS Depressants

revefenacin 

revefenacin: they may increase the CNS depressant effect of CNS Depressants

pitolisant 

pitolisant: they may increase the CNS depressant effect of CNS Depressants

betahistine 

betahistine: they may increase the CNS depressant effect of CNS Depressants

chloral hydrate 

chloral hydrate: they may increase the CNS depressant effect of CNS Depressants

doxofylline 

doxofylline: they may increase the CNS depressant effect of CNS Depressants

talazoparib

may diminish the serum concentration of each other when combined

niraparib

may diminish the serum concentration of each other when combined

brompheniramine

may increase the efficacy of each other when combined

alogliptin 

alogliptin: it may increase the risk of methemoglobinemia agents

alvimopan 

alvimopan: it may increase the risk of methemoglobinemia agents

balsalazide 

balsalazide: it may increase the risk of methemoglobinemia agents

remimazolam

may increase the harmful effects of CNS depressants

primidone

may increase the harmful effects of CNS depressants

phenobarbital

may increase the harmful effects of CNS depressants

amobarbital

may increase the harmful effects of CNS depressants

butalbital

may increase the harmful effects of CNS depressants

levodopa

methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics

bupivacaine

methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics

levobupivacaine

methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics

lidocaine

methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics

procaine benzylpenicillin

methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics

mibefradil

Barbiturates may enhance the hypotensive effect of Blood Pressure Lowering Agents

indoramin

Barbiturates may enhance the hypotensive effect of Blood Pressure Lowering Agents

amlodipine/atorvastatin

Barbiturates may enhance the hypotensive effect of Blood Pressure Lowering Agents

terazosin

Barbiturates may enhance the hypotensive effect of Blood Pressure Lowering Agents

atenolol

Barbiturates may enhance the hypotensive effect of Blood Pressure Lowering Agents

acenocoumarol

may increase the metabolism of Vitamin K Antagonists

fluindione

may increase the metabolism of Vitamin K Antagonists

phenindione

may increase the metabolism of Vitamin K Antagonists

phylloquinone

may increase the metabolism of Vitamin K Antagonists

warfarin

may increase the metabolism of Vitamin K Antagonists

diphenoxylate/atropine

CNS depressants increase the toxicity of CNS depressants

phenobarbital

CNS depressants increase the toxicity of CNS depressants

clozapine

CNS depressants increase the toxicity of CNS depressants

ketamine

CNS depressants increase the toxicity of CNS depressants

propofol

CNS depressants increase the toxicity of CNS depressants

nabilone

may increase the CNS depressant effect of cannabinoid-containing products

cannabidiol

may increase the CNS depressant effect of cannabinoid-containing products

hydrocodone/pseudoephedrine

may increase the CNS depressant effect of opioid agonists

codeine

may increase the CNS depressant effect of opioid agonists

morphine

may increase the CNS depressant effect of opioid agonists

diphenoxylate/atropine

may increase the risk of adverse effect of other CNS depressants

phenobarbital

may increase the risk of adverse effect of other CNS depressants

estazolam

may increase the risk of adverse effect of other CNS depressants

oxazepam

may increase the risk of adverse effect of other CNS depressants

tiagabine

may increase the risk of adverse effect of other CNS depressants

mibefradil

may increase the hypotensive effect

indoramin

may increase the hypotensive effect

amlodipine/atorvastatin

may increase the hypotensive effect

terazosin

may increase the hypotensive effect

atenolol

may increase the hypotensive effect

apomorphine

may enhance the adverse/toxic effect of other CNS depressants

flurazepam

may enhance the adverse/toxic effect of other CNS depressants

perphenazine

may enhance the adverse/toxic effect of other CNS depressants

diazepam

may enhance the risk of adverse/toxic effect of other CNS depressants

methadone

may enhance the risk of adverse/toxic effect of other CNS depressants

secobarbital

may enhance the risk of adverse/toxic effect of other CNS depressants

tranylcypromine

barbiturates may increase the metabolism of tricyclic antidepressants

dextromethorphan/bupropion

barbiturates may increase the metabolism of tricyclic antidepressants

amitriptyline

barbiturates may increase the metabolism of tricyclic antidepressants

brexanolone

barbiturates may increase the metabolism of tricyclic antidepressants

mirtazapine

barbiturates may increase the metabolism of tricyclic antidepressants

remifentanil

may enhance the CNS depressant effect of Opioid Agonists

hydrocodone/pseudoephedrine

may enhance the CNS depressant effect of Opioid Agonists

codeine

may enhance the CNS depressant effect of Opioid Agonists

morphine

may enhance the CNS depressant effect of Opioid Agonists

estropipate

may reduce the level of serum concentration of estrogen drugs

bazedoxifene/conjugated estrogens

may reduce the level of serum concentration of estrogen drugs

conjugated estrogens

may reduce the level of serum concentration of estrogen drugs

diethylstilbestrol

may reduce the level of serum concentration of estrogen drugs

esterified estrogens

may reduce the level of serum concentration of estrogen drugs

clorazepic acid

they increase the toxicity of other CNS depressants

isoflurane

they increase the toxicity of other CNS depressants