- March 15, 2022
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Brand Name :
Synthroid, Levoxyl, Unithroid, Thyquidity, Levolet, Levo T, Tirosint
Synonyms :
Class :
thyroid disease and t4 releasing hormone
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Brand Name :
Synthroid, Levoxyl, Unithroid, Thyquidity, Levolet, Levo T, Tirosint
Synonyms :
Class :
thyroid disease and t4 releasing hormone
Dosage Forms & Strengths:
Capsule:
(175, 20, 13, 25, 50, 75, 88, 100, 112, 125, 137, 150) mcg
Solution, Intravenous:
100 mcg/5 ml (5 ml)
Solution, Intravenous [preservative free]:
(100, 200, 500) mcg/5 ml (5 ml)
Solution:
(37.5, 44, 62.5) mcg/ml (1 ml)
Solution, Oral:
Thyquidity: 100 mcg/5 ml
Tirosint: (13, 25, 50, 75, 88, 100, 112, 137, 150, 175, 200) mcg/ml (1 ml)
Tablet, Oral, as sodium:
(25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200) mcg
300 - 500
mcg
Intravenous (IV)
once a day
Or 50-100 mcg once a day until patient can tolerate
1.7
mcg
Orally
once a day
Age: >50 years old or less than 50 years with CV disease
25-50 mcg orally once a day
Or 12.5-25 mcg every 6-8Week
Age: >50 years with CV disease
12.5-25 mcg orally once a day
Or 12.5-25 mcg for every 4-6weeks until the patient becomes euthyroid
Severe Hypothyroidism
12.5-25 mcg orally once a day
Subclinical Hypothyroidism
1 mcg/kg orally once a day
Dosage Forms and Strengths
Capsule:
(175, 20, 13, 25, 50, 75, 88, 100, 112, 125, 137, 150) mcg
Solution, Intravenous:
100 mcg/5 ml (5 ml)
Solution, Intravenous [preservative free]:
(100, 200, 500) mcg/5 ml (5 ml)
Solution:
(37.5, 44, 62.5) mcg/ml (1 ml)
Solution, Oral:
Thyquidity: 100 mcg/5 ml
Tirosint: (13, 25, 50, 75, 88, 100, 112, 137, 150, 175, 200) mcg/ml (1 ml)
Tablet, Oral, as sodium:
(25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200) mcg
Age1-3 months
10-15 mcg/kg orally once a day
5-7.5 mcg/kg IV/IM once a day
For patients' risk of heart failure: 25 mcg/day
start a higher dose (50 mcg/day) as initial if serum T4 is lower than five mcg/dL
Age 3-6 months
8-10 mcg/kg orally OR 25-50 mcg orally once a day
4-7.5 mcg/kg IV/IM once a day
Age: 6-12 months
6-8 mcg/kg orally OR 50-75 mcg orally once a day
3-6 mcg/kg IV/IM once a day
Age: 1-5 years
5-6 mcg/kg orally, OR 75-100 mcg orally once a day
2.5-4.5 mcg/kg IV/IM once a day
Age: 6-12 years
4-5 mcg/kg orally OR 100-125 mcg orally once a day
2-3.75 mcg/kg IV/IM once a day
Age: >12 years
2-3 mcg/kg orally, OR 150 mcg orally once a day
1-2.25 mcg/kg IV/IM once a day
Sucralfate may diminish the serum concentration of levothyroxin
may diminish the serenum concentration of iron preparations
may diminish the serum concentration when combined with levothyroxine
may diminish the serum concentration of magnesium salts
may have a decreased serum concentration when combined with levothyroxine
may have a decreased serum concentration when combined with levothyroxine
may have a decreased serum concentration when combined with levothyroxine
may have a decreased serum concentration when combined with levothyroxine
may have a decreased serum concentration when combined with levothyroxine
may enhance the adverse/toxic effect of sympathomimetics
may enhance the adverse/toxic effect of sympathomimetics
may enhance the adverse/toxic effect of sympathomimetics
may enhance the adverse/toxic effect of sympathomimetics
may enhance the adverse/toxic effect of sympathomimetics
may have an increasingly adverse effect when combined with sympathomimetics
may have an increasingly adverse effect when combined with sympathomimetics
may increase GI absorption of levothyroxine and decrease serum levels
may increase the toxic effect of sympathomimetics
may increase the toxic effect of sympathomimetics
may diminish the serum concentration when combined with levothyroxine
Adverse drug reactions:
Frequency Not Defined
Anxiety
Choking sensation
Cramps
Diarrhea
Nervousness
Emotional lability
Headache
Heat intolerance
Insomnia
Myasthenia
Pseudotumor cerebri
Fever
Myocardial infarction
Palpitations
Arrhythmias
Tachycardia
Tremor
Alopecia
Weight loss
Infertility
Dyspnea
Decreased bone mineral density
Angina pectoris
Arthralgia
Congestive heart failure
Flushing
Increased pulse
Pregnancy warnings:
AU TGA pregnancy category: A
US FDA pregnancy category: Not Assigned
Breastfeeding warnings:
The release of the drug into the human breastmilk is known
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: levothyroxine (Rx)
Why do we use levothyroxine (Rx)?
Levothyroxine is used to treat hypothyroidism. This drug usually helps when there is deficiency of thyroid hormone in our body.
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