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» Home » CAD » Endocrinology » Thyroid » Hypothyroidism
Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
1.7
mcg
Orally
once a day
Age: >50 years old or less than 50 years with CV disease
25-50 mcg orally once a day
Or 12.5-25 mcg every 6-8Week
Age: >50 years with CV disease
12.5-25 mcg orally once a day
Or 12.5-25 mcg for every 4-6weeks until the patient becomes euthyroid
Severe Hypothyroidism
12.5-25 mcg orally once a day
Subclinical Hypothyroidism
1 mcg/kg orally once a day
Initially, 25-75 mcg orally each day
It increases by 25 mcg every 1-2 weeks, do not exceed 100 mcg/day
Maintenance dose- 25-75 mcg orally each day
May also use 10-12.5 mcg triiodothyronine (T3) combined with tetraiodothyronine (T4)
Decrease the T4 dose by 50 mcg
Initially, 25-75 mcg orally each day
It increases by 25 mcg every 1-2 weeks, do not exceed 100 mcg/day
Maintenance dose- 25-75 mcg orally each day
May also use 10-12.5 mcg triiodothyronine (T3) combined with tetraiodothyronine (T4)
Decrease the T4 dose by 50 mcg
1 tablet Thyrolar 1/2 daily, followed by 1 tablet Thyrolar 1/4 every 2 to 3 weeks
In long-standing myxedema, a lower initial dose of 1 tab is recommended, especially if cardiovascular damage is suspected, in which further caution is advised
Maintenance: one tablet of Thyrolar 1 to 1 tablet Thyrolar 2 daily; failure to respond to tab Thyrolar 3 can suggest a lack of compliance and malabsorption.
After necessary clinical laboratory analyses of T4 bound and free TSH blood levels, adjust the dosage within the first four weeks of therapy
Age1-3 months
10-15 mcg/kg orally once a day
5-7.5 mcg/kg IV/IM once a day
For patients' risk of heart failure: 25 mcg/day
start a higher dose (50 mcg/day) as initial if serum T4 is lower than five mcg/dL
Age 3-6 months
8-10 mcg/kg orally OR 25-50 mcg orally once a day
4-7.5 mcg/kg IV/IM once a day
Age: 6-12 months
6-8 mcg/kg orally OR 50-75 mcg orally once a day
3-6 mcg/kg IV/IM once a day
Age: 1-5 years
5-6 mcg/kg orally, OR 75-100 mcg orally once a day
2.5-4.5 mcg/kg IV/IM once a day
Age: 6-12 years
4-5 mcg/kg orally OR 100-125 mcg orally once a day
2-3.75 mcg/kg IV/IM once a day
Age: >12 years
2-3 mcg/kg orally, OR 150 mcg orally once a day
1-2.25 mcg/kg IV/IM once a day
Indicated for Congenital hypothyroidism
Initially 5 mcg orally each day
May increase the dose by 5 mcg every 3-4 days
Maintenance dose
For <1 year: 20 mcg orally each day
For 1-3 years: 50 mcg orally each day
For >3 years: 25-75 mcg orally each day
0 to 6 months: 3.1/12.5 to 6.25/25 orally;
6 to 12 months: 6.25/25 to 9.35/37.5 orally;
1 to 5 yrs: 9.35/37.5 to 12.5/50 mcg orally;
6- to 12 yrs: 12.5/50 to 18.75/75 mcg orally;
Above 12 yrs: more than 18.75/75 mcg orally;
Future Trends
References
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» Home » CAD » Endocrinology » Thyroid » Hypothyroidism
1.7
mcg
Orally
once a day
Age: >50 years old or less than 50 years with CV disease
25-50 mcg orally once a day
Or 12.5-25 mcg every 6-8Week
Age: >50 years with CV disease
12.5-25 mcg orally once a day
Or 12.5-25 mcg for every 4-6weeks until the patient becomes euthyroid
Severe Hypothyroidism
12.5-25 mcg orally once a day
Subclinical Hypothyroidism
1 mcg/kg orally once a day
Initially, 25-75 mcg orally each day
It increases by 25 mcg every 1-2 weeks, do not exceed 100 mcg/day
Maintenance dose- 25-75 mcg orally each day
May also use 10-12.5 mcg triiodothyronine (T3) combined with tetraiodothyronine (T4)
Decrease the T4 dose by 50 mcg
Initially, 25-75 mcg orally each day
It increases by 25 mcg every 1-2 weeks, do not exceed 100 mcg/day
Maintenance dose- 25-75 mcg orally each day
May also use 10-12.5 mcg triiodothyronine (T3) combined with tetraiodothyronine (T4)
Decrease the T4 dose by 50 mcg
1 tablet Thyrolar 1/2 daily, followed by 1 tablet Thyrolar 1/4 every 2 to 3 weeks
In long-standing myxedema, a lower initial dose of 1 tab is recommended, especially if cardiovascular damage is suspected, in which further caution is advised
Maintenance: one tablet of Thyrolar 1 to 1 tablet Thyrolar 2 daily; failure to respond to tab Thyrolar 3 can suggest a lack of compliance and malabsorption.
After necessary clinical laboratory analyses of T4 bound and free TSH blood levels, adjust the dosage within the first four weeks of therapy
Age1-3 months
10-15 mcg/kg orally once a day
5-7.5 mcg/kg IV/IM once a day
For patients' risk of heart failure: 25 mcg/day
start a higher dose (50 mcg/day) as initial if serum T4 is lower than five mcg/dL
Age 3-6 months
8-10 mcg/kg orally OR 25-50 mcg orally once a day
4-7.5 mcg/kg IV/IM once a day
Age: 6-12 months
6-8 mcg/kg orally OR 50-75 mcg orally once a day
3-6 mcg/kg IV/IM once a day
Age: 1-5 years
5-6 mcg/kg orally, OR 75-100 mcg orally once a day
2.5-4.5 mcg/kg IV/IM once a day
Age: 6-12 years
4-5 mcg/kg orally OR 100-125 mcg orally once a day
2-3.75 mcg/kg IV/IM once a day
Age: >12 years
2-3 mcg/kg orally, OR 150 mcg orally once a day
1-2.25 mcg/kg IV/IM once a day
Indicated for Congenital hypothyroidism
Initially 5 mcg orally each day
May increase the dose by 5 mcg every 3-4 days
Maintenance dose
For <1 year: 20 mcg orally each day
For 1-3 years: 50 mcg orally each day
For >3 years: 25-75 mcg orally each day
0 to 6 months: 3.1/12.5 to 6.25/25 orally;
6 to 12 months: 6.25/25 to 9.35/37.5 orally;
1 to 5 yrs: 9.35/37.5 to 12.5/50 mcg orally;
6- to 12 yrs: 12.5/50 to 18.75/75 mcg orally;
Above 12 yrs: more than 18.75/75 mcg orally;
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