Brand Name :
Khedezla, pristiq
Synonyms :
Class :
Serotonin-norepinephrine reuptake inhibitors
Dosage Forms & Strengths
Tablet, extended release:
25mg,50mg,100mg
50 - 400
mg
Orally
every day
Tablet
Dose Adjustments
Renal impairment:
Mild (CrCl≥50ml/min): No dosage adjustment is necessary
Moderate (CrCl 30-50ml/min): Do not exceed 50mg/day orally
Severe (CrCl<30ml/min): Do not exceed 25mg/day orally or 50 mg orally
every other day
Hepatic impairment:
Moderate-severe:50mg orally every day
Do not exceed more than 100mg/day
Refer adult dosing
may have an increased tachycardic effect when combined with Alpha-/Beta-Agonists
may have an increased tachycardic effect when combined with alpha-/beta-agonists
may increase the tachycardic effect of Alpha-/Beta-Agonists
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may decrease the therapeutic effect when combined with Iobenguane Radiopharmaceutical Products
may decrease the therapeutic effect when combined with Iobenguane Radiopharmaceutical Products
may decrease the therapeutic effect when combined with Iobenguane Radiopharmaceutical Products
may decrease the therapeutic effect when combined with Iobenguane Radiopharmaceutical Products
may decrease the therapeutic effect when combined with Iobenguane Radiopharmaceutical Products
It may enhance serotonin levels when combined with tramadol
The sympathomimetic (adrenergic) effects of pseudoephedrine are enhanced by desvenlafaxine
may have an increased antiplatelet effect when combined with Abrocitinib
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
may have an increased serotonergic effect when combined with Methylene Blue
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
may decrease the therapeutic effect when combined with Alpha2-Agonists
may decrease the therapeutic effect when combined with Alpha2-Agonists
may decrease the therapeutic effect when combined with Alpha2-Agonists
may decrease the therapeutic effect when combined with Alpha2-Agonists
may decrease the therapeutic effect when combined with Alpha2-Agonists
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may increase the vasopressor effect
may enhance the tachycardic effect
may enhance the tachycardic effect
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
it may diminish the excretion rate when combined with gadofosveset, resulting in an enhanced serum level
it may diminish the excretion rate when combined with pentastarch, resulting in an enhanced serum level
desvenlafaxine has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
may have an increased antiplatelet effect when combined with Aspirin
may have an increased CNS depressant effect when combined with Brexanolone
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
may increase the QTc prolonging effect of QTc prolonging agents
may increase the QTc-prolonging effect of QT-Prolonging Inhalational Anesthetics
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may affecting the metabolism and increase the side effects when combined with kratom
may enhance the QTc-prolonging effect of each other when combined
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
Frequency defined:
>10%
Dizziness
Constipation
Dry mouth
Fatigue
Insomnia
Somnolence
1-10%
Anorgasmia
Anxiety
Blurred vision
Chills
Decreased appetite
Hot flush
Nervousness
Syncope
Urinary retention
Frequency not defined:
Hyponatremia
Elevated blood pressure
Abnormal bleeding
Seizure
Narrow-angle glaucoma
Hypomania
Post marketing reports:
Pancreatitis acute
Stevens-johnson syndrome
Takotsubu cardiomyopathy
Pregnancy consideration: Insufficient data available
Lactation: The excretion of drugs in the human breast milk is unknown
Pregnancy category:
Patient information leaflet
Generic Name: desvenlafaxine
Pronounced: [ des-VEN-la-FAX-een]
Why do we use desvenlafaxine?
It is used to treat depression and it also functions by assisting with the restoration of the brain’s natural chemical equilibrium of serotonin and norepinephrine
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