Brand Name :
Zebeta, Monocor
Synonyms :
bisoprolol
Class :
Beta-1 Selective, Beta-Blockers
Brand Name :
Zebeta, Monocor
Synonyms :
bisoprolol
Class :
Beta-1 Selective, Beta-Blockers
Dosage Forms & Strengths
Tablet
5mg
10mg
Safety & efficacy not established
Refer to adult dosing
may decrease the bronchodilatory effect
CYP3A strong enhancers of the small intestine may reduce the bioavailability of bisoprolol
may enhance the anti-hypertensive effect when both drugs are combined
may decrease the bronchodilatory effect
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
beta-Blockers may enhance the adverse/toxic effect of cholinergic agonists
beta-Blockers may enhance the adverse/toxic effect of cholinergic agonists
beta-Blockers may enhance the adverse/toxic effect of cholinergic agonists
beta-Blockers may enhance the adverse/toxic effect of cholinergic agonists
beta-Blockers may enhance the adverse/toxic effect of cholinergic agonists
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
May enhance the hypotensive effect of beta-Blockers
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
may enhance the hypoglycemic effect of antidiabetic agents
may enhance the hypoglycemic effect of antidiabetic agents
may enhance the hypoglycemic effect of antidiabetic agents
may enhance the hypoglycemic effect of antidiabetic agents
may enhance the hypoglycemic effect of antidiabetic agents
beta-blockers may increase the hypoglycemic effect of antidiabetic agents
beta-blockers may increase the hypoglycemic effect of antidiabetic agents
beta-blockers may increase the hypoglycemic effect of antidiabetic agents
beta-blockers may increase the hypoglycemic effect of antidiabetic agents
beta-blockers may increase the hypoglycemic effect of antidiabetic agents
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may increase the adverse effect of cholinergic agonists
may increase the adverse effect of cholinergic agonists
may increase the adverse effect of cholinergic agonists
may increase the adverse effect of cholinergic agonists
may increase the adverse effect of cholinergic agonists
may increase the effect of insulins
may increase the effect of insulins
may increase the effect of insulins
may increase the effect of insulins
may increase the effect of insulins
it may increase the bradycardic effect of beta-blockers
it may increase the bradycardic effect of beta-blockers
it may increase the bradycardic effect of Beta-Blockers
it may increase the bradycardic effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
amiodarone may enhance the bradycardic effect of beta-blockers
it may enhance the serum potassium levels
when combined may increase anticoagulation
it enhances the serum potassium levels
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
it increases the effect of bradycardia of Beta-Blockers
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
Beta-Blockers increase the effect of hypoglycemia of insulins
may increase the toxic effect
may enhance the hypotensive effect of beta-blockers
may enhance the hypotensive effect of beta-blockers
may enhance the hypotensive effect of beta-blockers
may enhance the hypotensive effect of beta-blockers
may enhance the hypotensive effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may enhance the bradycardic effect of beta-blockers
may have an increased hypotensive effect when combined with nifedipine
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may reduce the effect of beta-blockers
may reduce the effect of beta-blockers
may reduce the effect of beta-blockers
may reduce the effect of beta-blockers
may reduce the effect of beta-blockers
may enhance the serum concentration when combined with mepivacaine
Actions and Spectrum:
Actions of bisoprolol include:
The spectrum of bisoprolol includes:
Frequency Defined
1-10%
Insomnia (8%-10%)
Dizziness (10%)
Upper respiratory infection (5%)
Rhinitis (4%)
Arthralgia (3%)
Diarrhea (4%)
Cough (3%)
Nausea (2%)
Dyspnea (2%)
Pharyngitis (2%)
Vomiting (2%)
Sinusitis (2%)
<1%
Hypotension
Cold extremities
Depression
Bronchospasm
Dyspepsia
Frequency Not Defined
Decrease HDL
Aggravate CHF
Hypertriglyceridemia
Decreased exercise tolerance
Mask symptoms of hypoglycemia
Black Box Warning
bisoprolol carries a Black Box Warning for its potential to cause serious and potentially life-threatening heart failure in patients with existing heart disease.
Contraindication/Caution:
Contraindications:
Cautions:
Pregnancy warnings:
US FDA pregnancy category: C
Lactation:
Excreted into human milk is unknown.
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
bisoprolol is a beta-blocker medication that works by blocking the action of certain hormones, such as adrenaline, on the heart and blood vessels. This results in a decrease in heart rate and blood pressure.
Pharmacodynamics:
bisoprolol works by binding to beta-1 receptors in the heart and blood vessels, which results in a decrease in heart rate and blood pressure. It also reduces the workload on the heart and improves blood flow to the heart.
Pharmacokinetics:
Absorption
It is rapidly and well absorbed after oral administration. The maximum concentration of the drug in the blood (Cmax) is reached within 1-2 hours. Food does not affect the absorption of bisoprolol.
Distribution
bisoprolol is highly bound to plasma proteins (about 98%) and has a large volume of distribution (about 12L/kg). It also crosses the blood-brain barrier and the placenta.
Metabolism
It is metabolized in the liver by the cytochrome P450 3A4 enzyme. The main metabolite is the inactive 4′-hydroxybisoprolol.
Elimination and excretion
bisoprolol is excreted mainly in the urine, with about 70% of the dose excreted within 24 hours. The elimination half-life of bisoprolol is about 9-12 hours.
Administration:
Oral administration:
Bisoprolol is typically administered as a tablet or extended-release capsule, taken orally once or twice daily. The dosage and frequency of administration will depend on the condition being treated and the patient’s response to the medication.
It is important to take bisoprolol exactly as prescribed by a healthcare provider, and not to change the dosage or frequency without consulting a healthcare professional. Bisoprolol should be taken with food and should be taken at the same time each day to maintain a consistent level of the drug in the bloodstream.
Patients should be advised to swallow the tablet whole, and not to crush or chew it. If a dose is missed, it should be taken as soon as possible, unless it is close to the time for the next dose. In this case, the missed dose should be skipped, and the patient should continue with their regular dosing schedule.
Patients should also be advised to avoid drinking alcohol while taking bisoprolol, as it may increase the risk of side effects such as dizziness or drowsiness. Bisoprolol should also be used with caution in elderly patients, as they may be more sensitive to the drug’s effects.
Patient information leaflet
Generic Name: bisoprolol
Why do we use bisoprolol?
bisoprolol is a beta-blocker medication that is used for several medical conditions, including: