DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Frequency defined:  

>10% 

Renal insufficiency  

Jaundice  

Elevated liver function test values  

1-10% 

Dizziness  

Dyspepsia  

Epigastric pain  

Indigestion  

Nausea 

Constipation  

Depression  

Diarrhea  

Fatigue  

<1% 

Angioedema 

Aplastic anemia 

Asthma 

Bone marrow depression 

Congestive heart failure 

Pulmonary edema 

Thrombocytopenic purpura 

Ulcerative stomatitis 

Leukopenia 

Macular and morbilliform eruptions 

Post-marketing Reports 

Pancreatitis 

 

 

Pregnancy consideration: C 

Lactation: The drug is excreted in the human breast milk  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Patient information leaflet 

Generic Name: indomethacin 

Pronounced: (in doe meth’ a sin) 

Why do we use indomethacin? 

Indomethacin is used to treat mild to moderate acute pain and relieves symptoms of gout and arthritis.