DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Adverse drug reactions  

Frequency Defined  

>10%  

Hypotension (1-11%)  

Elevated Uric Acid (15%)  

Cough (1.9-35%)  

1-10%  

Hyperkalemia (5.3%)  

Syncope (5.9%)  

Dizziness (1.3-2.3%)  

Hypocalcemia (4.7%)  

Bradycardia (1-5%)  

Stroke (3.8%)  

Frequency Not Defined  

ARF if renal artery stenosis  

Angioedema  

Pregnancy warnings:     

AU TGA pregnancy category: D
US FDA pregnancy category: D 

Lactation: 

Excreted into human milk is unknown 

Pregnancy Categories:       

Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.       

Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women       

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women       

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.       

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.       

Category N: There is no data available for the drug under this category 

  

Patient Information Leaflet    

Generic Name: trandolapril  

Why do we use trandolapril? 

trandolapril is an ACE Inhibitors used to treat Post MI, Hypertension, and CHF.