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glimepiride - medtigo

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glimepiride

Brand Name :

Amaryl

Synonyms :

glimepiride

Class :

Antidiabetics, Sulfonylureas





No data available for drug.

Actions and Spectrum: 

glimepiride works by attaching to the ATP-sensitive potassium channels on the surface of pancreatic beta cells and causing them to close. The cell membrane depolarizes as a result of this closure, which leads to the release of insulin. 

glimepiride’s effect range is rather small; therefore, its main effects are on insulin and blood sugar levels. Other areas of metabolism or body processes are not significantly impacted. I

t is crucial to remember that glimepiride might result in hypoglycaemia (low blood sugar) as an adverse reaction, thus it must be taken carefully and with a doctor’s supervision. 

DRUG INTERACTION

glimepiride

&

  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • rabies immune globulin, human (RIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone (Pending FDA Approval)
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid (Pending FDA Approval)
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitnib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • ketoconazole topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/​linagliptin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
  • posiphen
  • acotiamide
  • triflupromazine
  • pegvisomant
  • pipecuronium
  • regramostim
  • phenserine
  • diethylcarbamazine
  • cinchocaine
  • pancuronium
  • bambuterol
  • hexafluronium
  • aprotinin
  • tyrothricin
  • decamethonium
  • ipidacrine
  • tubocurarine
  • paraoxon
  • ginkgo biloba
  • methanesulfonyl fluoride
  • dichlorvos
  • fenthion
  • metrifonate
  • coumaphos
  • huperzine A
  • distigmine
  • neostigmine
  • isoflurophate
  • tasosartan
  • fimasartan
  • methylthioninium
  • minaprine
  • gallamine triethiodide
  • ambenonium
  • abiraterone
  • mibefradil
  • hydrocortisone (systemic)
  • cetirizine (systemic)
  • Talimogene Laherparepvec
  • Diacerein
  • Magnesium glucoheptonate
  • acyclovir and hydrocortisone
  • acyclovir (ophthalmic)
  • acyclovir (topical)
  • docosanol cream
  • camphor and phenol
  • dolutegravir, abacavir, and lamivudine
  • peramivir
  • lisdexamfetamine
  • ergoloid mesylates
  • memantine/donepezil
  • tranylcypromine
  • isocarboxazid
  • methenamine/sodium salicylate/benzoic acid
  • mometasone topical (Rx)
  • Esketamine intranasal
  • Oracit
  • Shohls Solution
  • sodium lactate
  • sodium citrate
  • lecanemab
  • donepezil (Rx)
  • donepezil transdermal
  • sodium thiosulfate
  • ciclopirox
  • undecylenic acid
  • butenafine
  • calcium and vitamin D
  • zoledronic acid
  • calcitonin salmon
  • pizotifen
  • indoramin
  • salicylic acid acne
  • minoxidil topical
  • adapalene
  • orlistat
  • COVID-19 subunit vaccine
  • amoxicillin /vonoprazan
  • levamlodipine (Rx)
  • Omeprazole, amoxicillin, and clarithromycin
  • simvastatin/ezetimibe
  • amlodipine/atorvastatin
  • amoxicillin and clavulanate potassium
  • lansoprazole, amoxicillin, and clarithromycin
  • noradrenaline
  • carbaryl
  • botulinum toxin
  • atropine
  • artemether/lumefantrine
  • ergonovine
  • bunazosin (Not available in the United States)
  • ibalizumab
  • dolutegravir
  • hydrocodone/pseudoephedrine
  • cetirizine/pseudoephedrine
  • acetaminophen/dextromethorphan/pseudoephedrine/guaifenesin
  • acetaminophen IV/ibuprofen IV (Pending FDA Approval)
  • medroxyprogesterone
  • acetaminophen/caffeine
  • Acetaminophen/magnesium salicylate/pamabrom
  • megestrol
  • pyridoxine (vitamin B6)
  • folic acid-cyanocobalamin-pyridoxine
  • L-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
  • estropipate
  • betamethasone (systemic)
  • dolutegravir and lamivudine
  • zidovudine and lamivudine
  • mineral oil (oral/rectal)
  • regular insulin
  • dextromethorphan/bupropion
  • diphenhydramine/ibuprofen
  • enfuvirtide
  • doxapram
  • methamphetamine
  • dextroamphetamine
  • ephedrine
  • brompheniramine, dextromethorphan and phenylephrine
  • aspirin, chlorpheniramine, and phenylephrine
  • acetaminophen, pheniramine, and phenylephrine
  • chlorpheniramine and phenylephrine
  • guaifenesin and phenylephrine
  • rivastigmine
  • pyridostigmine
  • arecoline
  • physostigmine
  • abobotulinumtoxinA
  • echothiophate iodide
  • malathion
  • glibenclamide
  • rimabotulinumtoxinB
  • pioglitazone
  • daxibotulinumtoxinA
  • prabotulinumtoxinA
  • mepenzolate
  • trospium
  • modafinil
  • budesonide (oral inhalation)
  • budesonide (nasal)
  • budesonide (Topical)
  • vedolizumab
  • hydrocodone and homatropine
  • homatropine ophthalmic
  • methscopolamine
  • oxandrolone
  • nandrolone
  • fluoxymesterone
  • procyclidine
  • biperiden
  • benztropine
  • oxymetholone
  • ipratropium
  • belladonna/opium
  • pilocarpine
  • nicotine intranasal
  • succinylcholine
  • cromolyn sodium
  • mepolizumab
  • palivizumab
  • reslizumab
  • dupilumab
  • potassium iodide
  • beclomethasone (nasal)
  • tetrahydrozoline nasal
  • fluticasone (topical)
  • tecovirimat
  • entacapone
  • vaccinia immune globulin intravenous (Rx)
  • smallpox (vaccinia) vaccine, live
  • terazosin
  • labetalol 
  • smallpox and monkeypox vaccine (live, nonreplicating) (US: Availability limited to health department/CDC expanded access protocol) (Rx)
  • oxymetazoline
  • xylometazoline
  • meclizine
  • prazosin
  • belinostat
  • nabilone
  • tripelennamine
  • bismuth subcitrate, metronidazole and tetracycline
  • levalbuterol
  • rifaximin
  • cotrimoxazole
  • ethacrynic acid
  • senna
  • bisacodyl
  • sodium picosulfate, citric acid, and magnesium oxide
  • kaolin
  • anastrozole
  • docusate
  • cascara
  • dichlorphenamide
  • bismuth subsalicylate
  • methylcellulose
  • magnesium sulfate 
  • talazoparib
  • diphenoxylate/atropine
  • bacillus clausii
  • psyllium
  • bifidobacterium
  • lactobacillus
  • saccharomyces boulardii
  • lanreotide
  • cyproterone
  • ramucirumab (Rx)
  • fidaxomicin
  • tobramycin (systemic)
  • dacomitinib
  • pembrolizumab
  • amikacin (systemic)
  • panitumumab
  • blinatumomab
  • durvalumab
  • olaratumab
  • necitumumab
  • moxetumomab pasudotox
  • mogamulizumab
  • inotuzumab
  • dinutuximab
  • pentamycin
  • dibekacin
  • cemiplimab
  • gemtuzumab
  • demeclocycline
  • omadacycline
  • tobramycin (ophthalmic)
  • sarecycline
  • cefiderocol
  • valrubicin
  • plicamycin
  • denileukin diftitox
  • decitabine
  • niraparib
  • methacholine
  • carbachol
  • bethanechol
  • acetylcholine
  • atezolizumab
  • raloxifene
  • avelumab
  • leucovorin
  • cladabrine
  • pralatrexate
  • meclofenamate
  • pemetrexed
  • ustekinumab
  • diroximel fumarate
  • daratumumab
  • coccidioidin skin test
  • candida albicans extract
  • brewer’s yeast
  • poliovirus vaccine, live, trivalent
  • elotuzumab
  • trimetrexate
  • l-methyl folate
  • methyclothiazide
  • Influenza virus vaccine
  • acitretin
  • tafamidis
  • sapropterin
  • Pidotimod
  • nitisinone
  • mipomersen
  • levetiracetam
  • Inebilizumab
  • Diethylamine salicylate
  • COVID-19 vaccine
  • Cephalothin
  • alitretinoin
  • Alitretinoin
  • methotrexate
  • verteporfin
  • omacetaxine
  • methyl aminolevulinate topical
  • efgartigimod alfa
  • aminolevulinic acid
  • cetuximab
  • streptozocin
  • zoster vaccine recombinant
  • lyme disease vaccine
  • human papillomavirus vaccine
  • daclizumab
  • lomustiine
  • amitriptyline
  • triptorelin
  • Tedizolid
  • rituximab
  • darolutamide
  • altretamine
  • Varicella-zoster vaccine
  • topotecan
  • ajmaline
  • pneumococcal vaccine
  • poliovirus vaccine
  • adenovirus vaccine type 7
  • adenovirus vaccine type 4
  • brincidofovir
  • lenograstim
  • ofatumumab
  • doxorubicin
  • thioguanine
  • tetanus toxoid
  • primidone
  • lipegfilgrastim
  • pegaspargase
  • monomethyl fumarate
  • ibritumomab
  • dimethyl fumarate
  • varicella-zoster vaccine (recombinant)
  • influenza virus vaccine, h5n1, live
  • carmustine
  • influenza virus vaccine (h5n1), adjuvanted
  • influenza a (h5n1) vaccine
  • eluxadoline
  • influenza virus vaccine quadrivalent, adjuvanted
  • idecabtagene vicleucel
  • adenovirus types 4 and 7 live, oral
  • thiotepa
  • tocilizumab
  • levodopa inhaled
  • efalizumab
  • canakinumab
  • aminoglutethimide
  • ado-trastuzumab emtansine
  • adenovirus vaccine
  • zoster vaccine live
  • typhoid vaccine, live
  • influenza virus vaccine, live, trivalent
  • influenza virus vaccine, h1n1, live
  • delavirdine
  • paclitaxel
  • siltuximab
  • miconazole
  • fludarabine
  • epirubicin
  • vinblastine
  • lomustine
  • risankizumab
  • rilonacept
  • pacritinib
  • linezolid
  • griseofulvin
  • vincristine
  • rufinamide
  • phenobarbital
  • nelarabine
  • mitoxantrone
  • mitomycin
  • mitapivat
  • letermovir
  • lasmiditan
  • idarubicin
  • filgrastim
  • elagolix
  • daunorubicin
  • daclatasvir
  • carfilzomib
  • anakinra
  • alefacept
  • thalidomide
  • teriflunomide
  • rubella virus vaccine
  • ozanimod
  • mumps virus vaccine
  • measles virus vaccine
  • golimumab
  • etanercept
  • certolizumab
  • adalimumab
  • etoposide
  • mechlorethamine
  • adenovirus type 7 vaccine
  • melphalan
  • palifermin
  • pimecrolimus
  • ropeginterferon alfa 2b
  • tacrolimus
  • tofacitinib
  • amphotericin B cholesteryl sulfate
  • amphotericin B deoxycholate
  • amphotericin B liposomal
  • amphotericin B phospholipid complex
  • anthrax vaccine adsorbed
  • denosumab
  • diphtheria & tetanus toxoids
  • echinacea
  • haemophilus influenzae type b vaccine
  • hepatitis A vaccine inactivated
  • hepatitis a/b vaccine
  • hepatitis b vaccine
  • HIV vaccine
  • human papillomavirus vaccine, quadrivalent
  • hydroxyurea
  • influenza virus vaccine (H5N1)
  • influenza virus vaccine trivalent
  • influenza virus vaccine trivalent, adjuvanted
  • influenza virus vaccine trivalent, recombinant
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • meningococcal A C Y and W-135 polysaccharide vaccine combined
  • meningococcal group B vaccine
  • ofatumumab SC
  • pneumococcal vaccine 13-valent
  • pneumococcal vaccine heptavalent
  • pneumococcal vaccine polyvalent
  • poliovirus vaccine inactivated
  • rabies vaccine
  • sipuleucel-T
  • trastuzumab
  • trastuzumab deruxtecan
  • eslicarbazepine acetate
  • vitamin A
  • rifampin
  • belzutifan
  • belimumab
  • belatacept
  • armodafinil
  • amobarbital
  • alemtuzumab
  • ocrelizumab
  • nivolumab
  • natalizumab
  • fingolimod
  • desogestrel
  • butalbital
  • brexanolone
  • zoster vaccine
  • yellow fever vaccine
  • varicella virus vaccine
  • smallpox vaccine
  • rotavirus vaccine
  • rubella vaccine
  • influenza virus vaccine quadrivalent
  • atracurium
  • dengue vaccine
  • tisagenlecleucel
  • lisocabtagene maraleucel
  • ciltacabtagene autoleucel
  • brexucabtagene autoleucel
  • axicabtagene ciloleucel
  • chlorambucil
  • ethinyl estradiol
  • dicumarol
  • atenolol
  • anisindione
  • penicillin G benzathine
  • sequelerin
  • chloramphenicol
  • heparin
  • enoxaparin
  • dalteparin
  • bivalirudin
  • argatroban
  • willow bark
  • bazedoxifene/conjugated estrogens
  • aspirin rectal
  • aspirin/citric acid/sodium bicarbonate
  • aspirin
  • ganaxolone
  • erythromycin stearate
  • erythromycin lactobionate
  • erythromycin ethylsuccinate
  • elbasvir/grazoprevir
  • daridorexant
  • cholera vaccine
  • lumacaftor/ivacaftor
  • dienogest/estradiol valerate
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glimepiride + 

colesevelam 

It may diminish the serum concentration when combined with colesevelam

alogliptin

may increase the hypoglycemic effect

sitagliptin

may increase the hypoglycemic effect

tranylcypromine

may increase the hypoglycaemic effect

isocarboxazid

may increase the hypoglycaemic effect

phenelzine

may increase the hypoglycaemic effect

rasagiline

may increase the hypoglycaemic effect

safinamide

may increase the hypoglycaemic effect

phenindione

may enhance the anticoagulant effect

phylloquinone

may enhance the anticoagulant effect

warfarin

may enhance the anticoagulant effect

acenocoumarol

may enhance the anticoagulant effect

fluindione

may enhance the anticoagulant effect

mipomersen 

It may enhance the toxicity when combined with mipomersen

oxandrolone

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

nandrolone

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

fluoxymesterone

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

nandrolone decanoate

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

danazol

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

levalbuterol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

acebutolol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

betaxolol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

bisoprolol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

carvedilol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

hydrochlorothiazide

may decrease the therapeutic effect

metolazone

may decrease the therapeutic effect

quinethazone

may decrease the therapeutic effect

trichlormethiazide

may decrease the therapeutic effect

alpha-lipoic acid 

it increases the effect of hypoglycemia of antidiabetic agents

nisoldipine 

may enhance the serum concentration of CYP2C9 inhibitors

tranylcypromine

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

isocarboxazid

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

phenelzine

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

rasagiline

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

safinamide

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

acebutolol 

may increase the hypoglycemic effect of beta blockers

carteolol ophthalmic 

may enhance the hypoglycemic effect of beta blockers

levalbuterol

may enhance the effect of sulfonylureas

acebutolol

may enhance the effect of sulfonylureas

penbutolol

may enhance the effect of sulfonylureas

pindolol

may enhance the effect of sulfonylureas

propranolol

may enhance the effect of sulfonylureas

acarbose

may enhance the hypoglycemic effect

miglitol

may enhance the hypoglycemic effect

alogliptin

dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of sulfonylureas

sitagliptin

dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of sulfonylureas

Frequency Defined 

1-10% 

Headache (1.5%) 

Asthenia (1.6%) 

Nausea (1.1%) 

Dizziness (1.7%) 

>10% 

Hypoglycemia (4-20%) 

<1% 

Pruritus 

Urticaria 

Allergic skin reactions 

Erythema 

Morbilliform or maculopapular eruptions 

Diarrhea 

Vomiting 

Agranulocytosis 

Gastrointestinal pain 

Anemia 

Elevation of liver enzyme levels 

Hepatic porphyria reactions 

Leukopenia 

Pancytopenia 

Thrombocytopenia, hemolytic 

Disulfiram-like reactions 

Hyponatremia 

Aplastic anemia 

Cholestasis 

Jaundice (rare) 

Post marketing reports 

Hemolytic anemia in patients with and without G6PD deficiency 

Hepatic impairment (e.g., jaundice, cholestasis), as well as hepatitis, which may progress to liver failure 

Serious hypersensitivity reactions, including angioedema, anaphylaxis, and Stevens- Johnson Syndrome 

Aplastic anemia, pancytopenia, Leukopenia, and agranulocytosis 

Hyponatremia and SIADH, most often in patients on other medications or increase release of antidiuretic hormone or have medical conditions known to cause hyponatremia 

Porphyria cutanea tarda, photosensitivity reactions and allergic vasculitis 

Dysgeusia 

Alopecia 

Thrombocytopenia (including severe cases with platelet count <10,000/mcL) and thrombocytopenic purpura 

Hepatic porphyria reactions and disulfiram-like reactions 

Black Box Warning 

According to the glimepiride black box warning, significant hypoglycaemia (low blood sugar) may occur, which can result in a coma or even death.

When glimepiride is used with certain other drugs, such as insulin or other sulfonylureas, or in those with kidney or liver disease, hypoglycaemia is more likely to happen. 

The warning also advises against using glimepiride in people with type 1 diabetes or diabetic ketoacidosis as the drug is ineffective in these situations. 

Contraindication/Caution: 

Contraindication: 

  • glimepiride or other sulfonylureas hypersensitivity 
  • diabetes type 1 
  • ketoacidosis in diabetics 
  • serious renal or liver illness 

Caution: 

  • glimepiride is not advised to be used during pregnancy or during nursing since it might enter the breast milk and damage the unborn child. 
  • Those over the age of 65 may require a different dosage of glimepiride because they may be more sensitive to its side effects. 
  • glimepiride has the potential to produce hypoglycaemia, especially in people with liver or renal disease and when used with other drugs that drop blood sugar. 
  • glimepiride may need to be temporarily discontinued during surgery or a condition that impairs appetite or raises the risk of hypoglycaemia. 
  • Alcohol should be avoided or consumed in moderation when taking glimepiride as it may increase the risk of hypoglycaemia. 

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology 

A second-generation sulfonylurea anti-diabetic medication called glimepiride increases the amount of insulin that the pancreatic beta cells secrete. It blocks the ATP-sensitive potassium channels (KATP) via binding to the sulfonylurea receptor (SUR) on the surface of pancreatic beta cells, which causes the membrane to depolarize and release insulin. 

Pharmacodynamics 

glimepiride’s effects on the pancreatic beta cells boost insulin production, which lowers blood glucose levels in people with type 2 diabetes mellitus. In reaction to glimepiride, the pancreatic beta cells produce insulin in a glucose-dependent way. As a result, the medication only promotes insulin release when blood glucose levels are high, assisting in the prevention of hypoglycemia. 

Pharmacokinetics 

Absorption  

Orally given glimepiride is quickly absorbed from the digestive tract. Almost 100% of the medication’s dosage is absorbed into the circulation, which indicates that the drug has a high bioavailability. To promote the best absorption, glimepiride should be taken with the first substantial meal of the day. 

Distribution 

More than 99% of glimepiride is protein-bound to serum albumin. It has a substantial volume of distribution, which suggests that it is dispersed among the tissues of the body. 

Metabolism 

The cytochrome P450 enzyme system, CYP2C9, largely metabolizes glimepiride in the liver. The inactive hydroxy derivative is the main metabolite. The carboxyl derivative and the cyclohexyl hydroxy methyl derivative are two further minor metabolites. 

Elimination and excretion 

glimepiride and its byproducts are eliminated in the feces (40%) and urine (60%) respectively. The medicine has an elimination half-life of around 5 to 9 hours, and total elimination happens 4 to 5 days following the last dose. 

Administration: 

glimepiride pills are taken orally to provide the medication. To achieve the best absorption, it is normally taken once daily with the first large meal of the day.

The pills should not be chewed, crushed, or broken and should be consumed whole with a glass of water. glimepiride dose is tailored to the patient’s glycaemic control and should be progressively increased to reach the desired blood glucose level. 

Patient information leaflet 

Generic Name: glimepiride 

Why do we use glimepiride? 

glimepiride is used to treat type 2 diabetes mellitus, a disease where the body has trouble using insulin properly and has high blood sugar levels as a result. By encouraging the secretion of insulin from the pancreas, the medication is used to assist in lowering blood glucose levels. 

ADVERTISEMENT 

glimepiride

Brand Name :

Amaryl

Synonyms :

glimepiride

Class :

Antidiabetics, Sulfonylureas




No data available for drug.

Dosage Forms & Strengths   

Tablet 

1 mg 

2 mg 

4 mg 

Dosage Forms & Strengths   

Safety and efficacy not determined 

Refer to adult dosing 

DRUG INTERACTION

glimepiride

&

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  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitnib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • ketoconazole topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/​linagliptin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
  • posiphen
  • acotiamide
  • triflupromazine
  • pegvisomant
  • pipecuronium
  • regramostim
  • phenserine
  • diethylcarbamazine
  • cinchocaine
  • pancuronium
  • bambuterol
  • hexafluronium
  • aprotinin
  • tyrothricin
  • decamethonium
  • ipidacrine
  • tubocurarine
  • paraoxon
  • ginkgo biloba
  • methanesulfonyl fluoride
  • dichlorvos
  • fenthion
  • metrifonate
  • coumaphos
  • huperzine A
  • distigmine
  • neostigmine
  • isoflurophate
  • tasosartan
  • fimasartan
  • methylthioninium
  • minaprine
  • gallamine triethiodide
  • ambenonium
  • abiraterone
  • mibefradil
  • hydrocortisone (systemic)
  • cetirizine (systemic)
  • Talimogene Laherparepvec
  • Diacerein
  • Magnesium glucoheptonate
  • acyclovir and hydrocortisone
  • acyclovir (ophthalmic)
  • acyclovir (topical)
  • docosanol cream
  • camphor and phenol
  • dolutegravir, abacavir, and lamivudine
  • peramivir
  • lisdexamfetamine
  • ergoloid mesylates
  • memantine/donepezil
  • tranylcypromine
  • isocarboxazid
  • methenamine/sodium salicylate/benzoic acid
  • mometasone topical (Rx)
  • Esketamine intranasal
  • Oracit
  • Shohls Solution
  • sodium lactate
  • sodium citrate
  • lecanemab
  • donepezil (Rx)
  • donepezil transdermal
  • sodium thiosulfate
  • ciclopirox
  • undecylenic acid
  • butenafine
  • calcium and vitamin D
  • zoledronic acid
  • calcitonin salmon
  • pizotifen
  • indoramin
  • salicylic acid acne
  • minoxidil topical
  • adapalene
  • orlistat
  • COVID-19 subunit vaccine
  • amoxicillin /vonoprazan
  • levamlodipine (Rx)
  • Omeprazole, amoxicillin, and clarithromycin
  • simvastatin/ezetimibe
  • amlodipine/atorvastatin
  • amoxicillin and clavulanate potassium
  • lansoprazole, amoxicillin, and clarithromycin
  • noradrenaline
  • carbaryl
  • botulinum toxin
  • atropine
  • artemether/lumefantrine
  • ergonovine
  • bunazosin (Not available in the United States)
  • ibalizumab
  • dolutegravir
  • hydrocodone/pseudoephedrine
  • cetirizine/pseudoephedrine
  • acetaminophen/dextromethorphan/pseudoephedrine/guaifenesin
  • acetaminophen IV/ibuprofen IV (Pending FDA Approval)
  • medroxyprogesterone
  • acetaminophen/caffeine
  • Acetaminophen/magnesium salicylate/pamabrom
  • megestrol
  • pyridoxine (vitamin B6)
  • folic acid-cyanocobalamin-pyridoxine
  • L-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
  • estropipate
  • betamethasone (systemic)
  • dolutegravir and lamivudine
  • zidovudine and lamivudine
  • mineral oil (oral/rectal)
  • regular insulin
  • dextromethorphan/bupropion
  • diphenhydramine/ibuprofen
  • enfuvirtide
  • doxapram
  • methamphetamine
  • dextroamphetamine
  • ephedrine
  • brompheniramine, dextromethorphan and phenylephrine
  • aspirin, chlorpheniramine, and phenylephrine
  • acetaminophen, pheniramine, and phenylephrine
  • chlorpheniramine and phenylephrine
  • guaifenesin and phenylephrine
  • rivastigmine
  • pyridostigmine
  • arecoline
  • physostigmine
  • abobotulinumtoxinA
  • echothiophate iodide
  • malathion
  • glibenclamide
  • rimabotulinumtoxinB
  • pioglitazone
  • daxibotulinumtoxinA
  • prabotulinumtoxinA
  • mepenzolate
  • trospium
  • modafinil
  • budesonide (oral inhalation)
  • budesonide (nasal)
  • budesonide (Topical)
  • vedolizumab
  • hydrocodone and homatropine
  • homatropine ophthalmic
  • methscopolamine
  • oxandrolone
  • nandrolone
  • fluoxymesterone
  • procyclidine
  • biperiden
  • benztropine
  • oxymetholone
  • ipratropium
  • belladonna/opium
  • pilocarpine
  • nicotine intranasal
  • succinylcholine
  • cromolyn sodium
  • mepolizumab
  • palivizumab
  • reslizumab
  • dupilumab
  • potassium iodide
  • beclomethasone (nasal)
  • tetrahydrozoline nasal
  • fluticasone (topical)
  • tecovirimat
  • entacapone
  • vaccinia immune globulin intravenous (Rx)
  • smallpox (vaccinia) vaccine, live
  • terazosin
  • labetalol 
  • smallpox and monkeypox vaccine (live, nonreplicating) (US: Availability limited to health department/CDC expanded access protocol) (Rx)
  • oxymetazoline
  • xylometazoline
  • meclizine
  • prazosin
  • belinostat
  • nabilone
  • tripelennamine
  • bismuth subcitrate, metronidazole and tetracycline
  • levalbuterol
  • rifaximin
  • cotrimoxazole
  • ethacrynic acid
  • senna
  • bisacodyl
  • sodium picosulfate, citric acid, and magnesium oxide
  • kaolin
  • anastrozole
  • docusate
  • cascara
  • dichlorphenamide
  • bismuth subsalicylate
  • methylcellulose
  • magnesium sulfate 
  • talazoparib
  • diphenoxylate/atropine
  • bacillus clausii
  • psyllium
  • bifidobacterium
  • lactobacillus
  • saccharomyces boulardii
  • lanreotide
  • cyproterone
  • ramucirumab (Rx)
  • fidaxomicin
  • tobramycin (systemic)
  • dacomitinib
  • pembrolizumab
  • amikacin (systemic)
  • panitumumab
  • blinatumomab
  • durvalumab
  • olaratumab
  • necitumumab
  • moxetumomab pasudotox
  • mogamulizumab
  • inotuzumab
  • dinutuximab
  • pentamycin
  • dibekacin
  • cemiplimab
  • gemtuzumab
  • demeclocycline
  • omadacycline
  • tobramycin (ophthalmic)
  • sarecycline
  • cefiderocol
  • valrubicin
  • plicamycin
  • denileukin diftitox
  • decitabine
  • niraparib
  • methacholine
  • carbachol
  • bethanechol
  • acetylcholine
  • atezolizumab
  • raloxifene
  • avelumab
  • leucovorin
  • cladabrine
  • pralatrexate
  • meclofenamate
  • pemetrexed
  • ustekinumab
  • diroximel fumarate
  • daratumumab
  • coccidioidin skin test
  • candida albicans extract
  • brewer’s yeast
  • poliovirus vaccine, live, trivalent
  • elotuzumab
  • trimetrexate
  • l-methyl folate
  • methyclothiazide
  • Influenza virus vaccine
  • acitretin
  • tafamidis
  • sapropterin
  • Pidotimod
  • nitisinone
  • mipomersen
  • levetiracetam
  • Inebilizumab
  • Diethylamine salicylate
  • COVID-19 vaccine
  • Cephalothin
  • alitretinoin
  • Alitretinoin
  • methotrexate
  • verteporfin
  • omacetaxine
  • methyl aminolevulinate topical
  • efgartigimod alfa
  • aminolevulinic acid
  • cetuximab
  • streptozocin
  • zoster vaccine recombinant
  • lyme disease vaccine
  • human papillomavirus vaccine
  • daclizumab
  • lomustiine
  • amitriptyline
  • triptorelin
  • Tedizolid
  • rituximab
  • darolutamide
  • altretamine
  • Varicella-zoster vaccine
  • topotecan
  • ajmaline
  • pneumococcal vaccine
  • poliovirus vaccine
  • adenovirus vaccine type 7
  • adenovirus vaccine type 4
  • brincidofovir
  • lenograstim
  • ofatumumab
  • doxorubicin
  • thioguanine
  • tetanus toxoid
  • primidone
  • lipegfilgrastim
  • pegaspargase
  • monomethyl fumarate
  • ibritumomab
  • dimethyl fumarate
  • varicella-zoster vaccine (recombinant)
  • influenza virus vaccine, h5n1, live
  • carmustine
  • influenza virus vaccine (h5n1), adjuvanted
  • influenza a (h5n1) vaccine
  • eluxadoline
  • influenza virus vaccine quadrivalent, adjuvanted
  • idecabtagene vicleucel
  • adenovirus types 4 and 7 live, oral
  • thiotepa
  • tocilizumab
  • levodopa inhaled
  • efalizumab
  • canakinumab
  • aminoglutethimide
  • ado-trastuzumab emtansine
  • adenovirus vaccine
  • zoster vaccine live
  • typhoid vaccine, live
  • influenza virus vaccine, live, trivalent
  • influenza virus vaccine, h1n1, live
  • delavirdine
  • paclitaxel
  • siltuximab
  • miconazole
  • fludarabine
  • epirubicin
  • vinblastine
  • lomustine
  • risankizumab
  • rilonacept
  • pacritinib
  • linezolid
  • griseofulvin
  • vincristine
  • rufinamide
  • phenobarbital
  • nelarabine
  • mitoxantrone
  • mitomycin
  • mitapivat
  • letermovir
  • lasmiditan
  • idarubicin
  • filgrastim
  • elagolix
  • daunorubicin
  • daclatasvir
  • carfilzomib
  • anakinra
  • alefacept
  • thalidomide
  • teriflunomide
  • rubella virus vaccine
  • ozanimod
  • mumps virus vaccine
  • measles virus vaccine
  • golimumab
  • etanercept
  • certolizumab
  • adalimumab
  • etoposide
  • mechlorethamine
  • adenovirus type 7 vaccine
  • melphalan
  • palifermin
  • pimecrolimus
  • ropeginterferon alfa 2b
  • tacrolimus
  • tofacitinib
  • amphotericin B cholesteryl sulfate
  • amphotericin B deoxycholate
  • amphotericin B liposomal
  • amphotericin B phospholipid complex
  • anthrax vaccine adsorbed
  • denosumab
  • diphtheria & tetanus toxoids
  • echinacea
  • haemophilus influenzae type b vaccine
  • hepatitis A vaccine inactivated
  • hepatitis a/b vaccine
  • hepatitis b vaccine
  • HIV vaccine
  • human papillomavirus vaccine, quadrivalent
  • hydroxyurea
  • influenza virus vaccine (H5N1)
  • influenza virus vaccine trivalent
  • influenza virus vaccine trivalent, adjuvanted
  • influenza virus vaccine trivalent, recombinant
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • meningococcal A C Y and W-135 polysaccharide vaccine combined
  • meningococcal group B vaccine
  • ofatumumab SC
  • pneumococcal vaccine 13-valent
  • pneumococcal vaccine heptavalent
  • pneumococcal vaccine polyvalent
  • poliovirus vaccine inactivated
  • rabies vaccine
  • sipuleucel-T
  • trastuzumab
  • trastuzumab deruxtecan
  • eslicarbazepine acetate
  • vitamin A
  • rifampin
  • belzutifan
  • belimumab
  • belatacept
  • armodafinil
  • amobarbital
  • alemtuzumab
  • ocrelizumab
  • nivolumab
  • natalizumab
  • fingolimod
  • desogestrel
  • butalbital
  • brexanolone
  • zoster vaccine
  • yellow fever vaccine
  • varicella virus vaccine
  • smallpox vaccine
  • rotavirus vaccine
  • rubella vaccine
  • influenza virus vaccine quadrivalent
  • atracurium
  • dengue vaccine
  • tisagenlecleucel
  • lisocabtagene maraleucel
  • ciltacabtagene autoleucel
  • brexucabtagene autoleucel
  • axicabtagene ciloleucel
  • chlorambucil
  • ethinyl estradiol
  • dicumarol
  • atenolol
  • anisindione
  • penicillin G benzathine
  • sequelerin
  • chloramphenicol
  • heparin
  • enoxaparin
  • dalteparin
  • bivalirudin
  • argatroban
  • willow bark
  • bazedoxifene/conjugated estrogens
  • aspirin rectal
  • aspirin/citric acid/sodium bicarbonate
  • aspirin
  • ganaxolone
  • erythromycin stearate
  • erythromycin lactobionate
  • erythromycin ethylsuccinate
  • elbasvir/grazoprevir
  • daridorexant
  • cholera vaccine
  • lumacaftor/ivacaftor
  • dienogest/estradiol valerate
  • zafirlukast
  • urofollitropin
  • tralokinumab
  • torsemide
  • tazarotene
  • pseudoephedrine
  • propoxiphene napsylate
  • propoxiphene hydrochloride
  • oxyphencyclimine hydrochloride
  • oxymetazoline hydrochloride
  • naxitamab
  • nandrolone decanoate
  • methylphenidate
  • methocarbamol
  • idoxuridine
  • hyaluronidase
  • hyaluronic acid
  • gonadoreline hydrochloride
  • glycopyrrolate
  • ganirelix acetate
  • gallium citrate
  • fulvestrant
  • fexofenadine hydrochloride
  • fenefluramine hydrochloride
  • febuxostat
  • famciclovir
  • ergocalciferol
  • divalproex sodium
  • diclorfenamide
  • dezocine
  • desmopressin acetate
  • demeclocycline hydrochloride
  • defibrotide sodium
  • deferiprone
  • deferasirox
  • daunorubicin hydrochloride
  • darunavir
  • darifenacin hydrobromide
  • daptomycin
  • dapsone
  • dantrolene sodium
  • danazol
  • dalafampridine
  • dalbavancin Hydrochloride
  • daclatasvir dihydrochloride
  • dactinomycin
  • dacitabine
  • cefiderocol sulfate tosylate
  • butoconazole nitrate
  • benralizumab (Rx)
  • albuterol
  • acetylcysteine
  • acebutolol
  • acam2000
  • abrocitinib
  • abatacept
  • abametapir
  • abaloparatide
  • chloroquine
  • ferric maltol
  • lorlatinib
  • piracetam
  • timolol
  • chlorothiazide
  • ferric pyrophosphate citrate
  • lornoxicam
  • piretanide
  • tinidazole
  • chloroxylenol
  • ferric sulfate
  • lorpiprazole
  • pirfenidone
  • tiopronin
  • chlorpheniramine
  • ferrous bisglycinate
  • losartan
  • piroxicam
  • tiotropium
  • chlorpromazine
  • ferrous fumarate
  • lovastatin
  • pitavastatin
  • tipranavir
  • chlorpropamide
  • ferrous gluconate
  • loxoprofen
  • pitolisant
  • tirofiban
  • chlorprothixene
  • ferrous succinate
  • lubiprostone
  • pivampicillin
  • tisotumab vedotin
  • chlorthalidone
  • ferrous sulfate anhydrous
  • lumateperone
  • pivmecillinam
  • tixocortol
  • chlorzoxazone
  • ferumoxides
  • lumefantrine
  • plazomicin
  • tizanidine
  • abiraterone
  • cholecalciferolc
  • ferumoxsil
  • lumiracoxib
  • plerixafor
  • tobramycin (oral inhalation)
  • acalabrutinib
  • choline c 11
  • ferumoxytol
  • lurasidone
  • polatuzumab vedotin
  • tocainide
  • acarbose
  • choline magnesium trisalicylate
  • fesoterodine
  • lurbinectedin
  • polythiazide
  • tocofersolan
  • aceclofenac
  • choline salicylate
  • fexinidazole
  • lynestrenol
  • pomalidomide
  • tocopherol
  • acemetacin
  • chondroitin sulfate
  • finasteride
  • macimorelin
  • ponatinib
  • acenocoumarol
  • chromic chloride
  • finerenone (Rx)
  • macitentan
  • ponesimod
  • tolazamide
  • acetaminophen
  • chromic nitrate
  • fish oil
  • magaldrate
  • posaconazole
  • tolbutamide
  • acetazolamide
  • chromium
  • flavoxate
  • magnesium
  • potassium
  • tolcapone
  • acetohexamide
  • chromium gluconate
  • flecainide
  • magnesium carbonate
  • potassium acetate
  • tolfenamic acid
  • acetylsalicylic acid
  • chromium nicotinate
  • flibanserin
  • magnesium chloride
  • potassium bicarbonate
  • tolmetin
  • acipimox
  • chromous sulfate
  • floctafenine
  • magnesium citrate
  • potassium cation
  • tolterodine
  • aclidinium
  • ciclesonide
  • florbetaben (18f)
  • magnesium gluconate
  • potassium chloride
  • tolvaptan
  • acrivastine
  • cidofovir
  • florbetapir (18f)
  • magnesium hydroxide
  • potassium citrate
  • topiramate
  • acyclovir
  • cilazapril
  • floxuridine
  • magnesium oxide
  • potassium nitrate
  • adefovir dipivoxil
  • cilostazol
  • flucloxacillin
  • magnesium silicate
  • potassium perchlorate
  • torasemide
  • adenosine
  • cimetidine
  • fluconazole
  • potassium sulfate
  • toremifene
  • agomelatine
  • cinacalcet
  • flucytosine
  • magnesium trisilicate
  • tositumomab
  • albendazole
  • cinnarizine
  • fludeoxyglucose (18f)
  • mangafodipir
  • pralidoxime
  • trabectedin
  • albiglutide
  • cinoxacin
  • fludrocortisone
  • manidipine
  • pralsetinib
  • tramadol
  • albutrepenonacog alfa
  • ciprofibrate
  • fluindione
  • mannitol
  • pramipexole
  • trametinib
  • alclofenac
  • cisapride
  • flumazenil
  • maprotiline
  • pramlintide
  • trandolapril
  • aldesleukin
  • cisplatin
  • flumethasone
  • maraviroc
  • prasugrel
  • trastuzumab emtansine
  • alectinib
  • citalopram
  • flunarizine
  • maribavir
  • pravastatin
  • trazodone
  • alendronic acid
  • cladribine
  • flunisolide
  • mebeverine
  • prazepamb
  • treprostinil
  • alfentanil
  • clarithromycin
  • flunitrazepam
  • mecamylamine
  • praziquantel
  • tretinoin
  • alfuzosin
  • clemastine
  • fluocinolone acetonide
  • mecasermin
  • prednisolone
  • triamcinolone
  • alimemazine
  • clevidipine
  • fluocinonide
  • meclofenamic acid
  • prednisolone acetate
  • triamterene
  • aliskiren
  • clindamycin
  • fluocortolone
  • medrogestone
  • prednisolone phosphate
  • triazolam
  • allopurinol
  • clobazam
  • fluorouracil
  • medroxyprogesterone acetate
  • prednisone (Rx)
  • trichlormethiazide
  • almasilate
  • clobetasol propionate
  • fluoxetine
  • mefenamic acid
  • prednisone acetate
  • triclabendazole
  • almotriptan
  • clofarabine
  • flupentixol
  • mefloquine
  • pregabalin
  • triethylenetetramine
  • alogliptin
  • clofazimine
  • fluprednisolone
  • megestrol acetate
  • pregnenolone
  • trifluoperazine
  • alosetron
  • clofibrate
  • flurazepam
  • melatonin
  • prenylamine
  • trifluridine
  • alpelisib
  • clomipramine
  • flurbiprofen
  • meloxicam
  • pretomanid
  • trilaciclib
  • alprazolam
  • fluspirilene
  • memantine
  • primaquine
  • trilostane
  • clonidine
  • flutamide
  • menthyl salicylate
  • probenecid
  • trimebutine
  • aluminium phosphate
  • clopidogrel
  • fluticasone (nasal)
glimepiride + 

colesevelam 

It may diminish the serum concentration when combined with colesevelam

alogliptin

may increase the hypoglycemic effect

sitagliptin

may increase the hypoglycemic effect

tranylcypromine

may increase the hypoglycaemic effect

isocarboxazid

may increase the hypoglycaemic effect

phenelzine

may increase the hypoglycaemic effect

rasagiline

may increase the hypoglycaemic effect

safinamide

may increase the hypoglycaemic effect

phenindione

may enhance the anticoagulant effect

phylloquinone

may enhance the anticoagulant effect

warfarin

may enhance the anticoagulant effect

acenocoumarol

may enhance the anticoagulant effect

fluindione

may enhance the anticoagulant effect

mipomersen 

It may enhance the toxicity when combined with mipomersen

oxandrolone

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

nandrolone

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

fluoxymesterone

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

nandrolone decanoate

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

danazol

may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects

levalbuterol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

acebutolol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

betaxolol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

bisoprolol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

carvedilol

beta-Blockers may enhance the hypoglycemic effect of sulfonylureas

hydrochlorothiazide

may decrease the therapeutic effect

metolazone

may decrease the therapeutic effect

quinethazone

may decrease the therapeutic effect

trichlormethiazide

may decrease the therapeutic effect

alpha-lipoic acid 

it increases the effect of hypoglycemia of antidiabetic agents

nisoldipine 

may enhance the serum concentration of CYP2C9 inhibitors

tranylcypromine

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

isocarboxazid

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

phenelzine

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

rasagiline

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

safinamide

may enhance the hypoglycemic effect of agents with blood glucose lowering effects

acebutolol 

may increase the hypoglycemic effect of beta blockers

carteolol ophthalmic 

may enhance the hypoglycemic effect of beta blockers

levalbuterol

may enhance the effect of sulfonylureas

acebutolol

may enhance the effect of sulfonylureas

penbutolol

may enhance the effect of sulfonylureas

pindolol

may enhance the effect of sulfonylureas

propranolol

may enhance the effect of sulfonylureas

acarbose

may enhance the hypoglycemic effect

miglitol

may enhance the hypoglycemic effect

alogliptin

dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of sulfonylureas

sitagliptin

dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of sulfonylureas

Actions and Spectrum: 

glimepiride works by attaching to the ATP-sensitive potassium channels on the surface of pancreatic beta cells and causing them to close. The cell membrane depolarizes as a result of this closure, which leads to the release of insulin. 

glimepiride’s effect range is rather small; therefore, its main effects are on insulin and blood sugar levels. Other areas of metabolism or body processes are not significantly impacted. I

t is crucial to remember that glimepiride might result in hypoglycaemia (low blood sugar) as an adverse reaction, thus it must be taken carefully and with a doctor’s supervision. 

Frequency Defined 

1-10% 

Headache (1.5%) 

Asthenia (1.6%) 

Nausea (1.1%) 

Dizziness (1.7%) 

>10% 

Hypoglycemia (4-20%) 

<1% 

Pruritus 

Urticaria 

Allergic skin reactions 

Erythema 

Morbilliform or maculopapular eruptions 

Diarrhea 

Vomiting 

Agranulocytosis 

Gastrointestinal pain 

Anemia 

Elevation of liver enzyme levels 

Hepatic porphyria reactions 

Leukopenia 

Pancytopenia 

Thrombocytopenia, hemolytic 

Disulfiram-like reactions 

Hyponatremia 

Aplastic anemia 

Cholestasis 

Jaundice (rare) 

Post marketing reports 

Hemolytic anemia in patients with and without G6PD deficiency 

Hepatic impairment (e.g., jaundice, cholestasis), as well as hepatitis, which may progress to liver failure 

Serious hypersensitivity reactions, including angioedema, anaphylaxis, and Stevens- Johnson Syndrome 

Aplastic anemia, pancytopenia, Leukopenia, and agranulocytosis 

Hyponatremia and SIADH, most often in patients on other medications or increase release of antidiuretic hormone or have medical conditions known to cause hyponatremia 

Porphyria cutanea tarda, photosensitivity reactions and allergic vasculitis 

Dysgeusia 

Alopecia 

Thrombocytopenia (including severe cases with platelet count <10,000/mcL) and thrombocytopenic purpura 

Hepatic porphyria reactions and disulfiram-like reactions 

Black Box Warning 

According to the glimepiride black box warning, significant hypoglycaemia (low blood sugar) may occur, which can result in a coma or even death.

When glimepiride is used with certain other drugs, such as insulin or other sulfonylureas, or in those with kidney or liver disease, hypoglycaemia is more likely to happen. 

The warning also advises against using glimepiride in people with type 1 diabetes or diabetic ketoacidosis as the drug is ineffective in these situations. 

Contraindication/Caution: 

Contraindication: 

  • glimepiride or other sulfonylureas hypersensitivity 
  • diabetes type 1 
  • ketoacidosis in diabetics 
  • serious renal or liver illness 

Caution: 

  • glimepiride is not advised to be used during pregnancy or during nursing since it might enter the breast milk and damage the unborn child. 
  • Those over the age of 65 may require a different dosage of glimepiride because they may be more sensitive to its side effects. 
  • glimepiride has the potential to produce hypoglycaemia, especially in people with liver or renal disease and when used with other drugs that drop blood sugar. 
  • glimepiride may need to be temporarily discontinued during surgery or a condition that impairs appetite or raises the risk of hypoglycaemia. 
  • Alcohol should be avoided or consumed in moderation when taking glimepiride as it may increase the risk of hypoglycaemia. 

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology 

A second-generation sulfonylurea anti-diabetic medication called glimepiride increases the amount of insulin that the pancreatic beta cells secrete. It blocks the ATP-sensitive potassium channels (KATP) via binding to the sulfonylurea receptor (SUR) on the surface of pancreatic beta cells, which causes the membrane to depolarize and release insulin. 

Pharmacodynamics 

glimepiride’s effects on the pancreatic beta cells boost insulin production, which lowers blood glucose levels in people with type 2 diabetes mellitus. In reaction to glimepiride, the pancreatic beta cells produce insulin in a glucose-dependent way. As a result, the medication only promotes insulin release when blood glucose levels are high, assisting in the prevention of hypoglycemia. 

Pharmacokinetics 

Absorption  

Orally given glimepiride is quickly absorbed from the digestive tract. Almost 100% of the medication’s dosage is absorbed into the circulation, which indicates that the drug has a high bioavailability. To promote the best absorption, glimepiride should be taken with the first substantial meal of the day. 

Distribution 

More than 99% of glimepiride is protein-bound to serum albumin. It has a substantial volume of distribution, which suggests that it is dispersed among the tissues of the body. 

Metabolism 

The cytochrome P450 enzyme system, CYP2C9, largely metabolizes glimepiride in the liver. The inactive hydroxy derivative is the main metabolite. The carboxyl derivative and the cyclohexyl hydroxy methyl derivative are two further minor metabolites. 

Elimination and excretion 

glimepiride and its byproducts are eliminated in the feces (40%) and urine (60%) respectively. The medicine has an elimination half-life of around 5 to 9 hours, and total elimination happens 4 to 5 days following the last dose. 

Administration: 

glimepiride pills are taken orally to provide the medication. To achieve the best absorption, it is normally taken once daily with the first large meal of the day.

The pills should not be chewed, crushed, or broken and should be consumed whole with a glass of water. glimepiride dose is tailored to the patient’s glycaemic control and should be progressively increased to reach the desired blood glucose level. 

Patient information leaflet 

Generic Name: glimepiride 

Why do we use glimepiride? 

glimepiride is used to treat type 2 diabetes mellitus, a disease where the body has trouble using insulin properly and has high blood sugar levels as a result. By encouraging the secretion of insulin from the pancreas, the medication is used to assist in lowering blood glucose levels. 

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