Brand Name :
Oxandrin
Synonyms :
oxandrolone, Oxandrolonum, Oxandrolona
Class :
Androgens
Dosage forms & Strengths
Tablet
2.5mg
10mg
Indicated for the joint pain that accompanies osteoporosis
2.5-20 mg/day orally divided every 6-12 hours for 2-4 weeks
May increase the dose as per requirement
Dosage forms & Strengths
Tablet
2.5mg
10mg
Refer to the adult dosing
may increase the hypoglycemic effect of blood glucose-lowering agents
may increase the hepatotoxic effect of cyclosporine
May increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
oxandrolone and pexidartinib both increase the effect of each other
oxandrolone and pretomanid both increase the toxicity of each other
oxandrolone increases the anticoagulatory effect of warfarin
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
corticosteroids may increase the fluid-retaining effect of androgens
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may have an increased hypertensive effect when combined with Androgens
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the hypoglycemic effect
they increase the effect of androgens
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypertensive effect of hypertension-associated agents
may increase the hypertensive effects of hypertension associated agents
may increase the fluid-retaining effect of corticosteroids
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may enhance the hypertensive effect of Androgens
may increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may increase the hypertensive effect of Hypertension-Associated Agents
It may increase the thrombogenic effect when combined with C1 inhibitors
may increase the hypoglycaemic effect with blood glucose lowering agents
may increase the hypoglycemic effect of Antidiabetic Agents
may increase the Glucose-lowering effect of Agents with Blood Glucose Lowering Effects
androgens increase the effect of hypoglycemia in these agents
androgens increase the effect of hypoglycemia in these agents
androgens increase the effect of hypoglycemia in these agents
androgens increase the toxic or adverse effect of ajmaline
may increase the hypertensive effect of hypertension-associated agents
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
may have an increased fluid-retaining effect when combined with androgens
androgens increase the effect of thrombogenesis of C1 inhibitors
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
Actions and Spectrum:
oxandrolone is a synthetic anabolic steroid, also known as “Anavar”. It is primarily used to help patients regain the weight they have lost due to certain medical conditions such as surgery, chronic infection, or severe trauma.
In terms of its actions, oxandrolone promotes muscle growth and increases the production of red blood cells, which can enhance endurance and athletic performance. It also has mild androgenic effects, which can promote the development of male characteristics such as a deeper voice and facial hair growth.
The spectrum of oxandrolone’s effects is relatively mild compared to other anabolic steroids, making it a popular choice for individuals who want to enhance their athletic performance or physical appearance without experiencing the more extreme side effects associated with other steroids.
Frequency not defined
Hirsutism
Male-pattern baldness
Menstrual irregularities
Virilism
Gynecomastia
Testicular function inhibition
Impotence
Priapism
Bladder irritability
Edema
Habituation
Libido changes
Acne
Electrolyte retention
Serum lipid levels
Cholestatic hepatitis
Jaundice
Black Box Warning:
The adverse conditions reported due to androgen therapy of anabolic steroids are peliosis, hepatitis, liver cell tumors, and changes in the blood lipid level.
Contraindication/Caution:
oxandrolone has several contraindications and precautions that should be considered before use:
Pregnancy consideration:
Category X
Breastfeeding warnings:
Do not breastfeed if taking oxandrolone
Pregnancy category:
Pharmacology:
oxandrolone is an orally administered synthetic anabolic steroid derived from dihydrotestosterone. It has a high oral bioavailability, meaning it is absorbed well from the gastrointestinal tract and quickly reaches high blood levels.
Once absorbed, oxandrolone is metabolized primarily in the liver and excreted in the urine. It has a half-life of approximately 9 hours, eliminating it from the body relatively quickly compared to other anabolic steroids.
oxandrolone also has a mild androgenic effect, which can promote the development of male characteristics such as a deeper voice and facial hair growth. However, this effect is relatively mild compared to other anabolic steroids.
Pharmacodynamics:
The pharmacodynamics of oxandrolone involves its effects on the body’s tissues and cells. oxandrolone is a synthetic derivative of dihydrotestosterone (DHT), a hormone that plays a role in developing and maintaining male sexual characteristics.
Like other anabolic steroids, oxandrolone works by binding to androgen receptors in cells throughout the body. This binding activates specific genetic pathways that stimulate the synthesis of proteins, leading to increased muscle mass, strength, and endurance. oxandrolone can also stimulate the production of red blood cells, enhancing athletic performance and endurance.
oxandrolone has a relatively mild androgenic effect compared to other anabolic steroids, which means that it is less likely to cause masculinizing effects such as deepening of the voice and facial hair growth in women. However, it can still cause these effects in high doses or prolonged use.
oxandrolone has also shown potential therapeutic benefits for specific medical conditions, including muscle wasting associated with HIV/AIDS, osteoporosis, and Turner syndrome.
Pharmacokinetics:
Absorption
oxandrolone is administered orally and is rapidly absorbed from the gastrointestinal tract, with peak blood levels reached within 1-2 hours after ingestion.
Distribution
Once absorbed, oxandrolone is transported by the bloodstream and distributed to various tissues throughout the body. It has a relatively low binding affinity for plasma proteins, meaning it can freely circulate in the bloodstream.
Metabolism
oxandrolone is primarily metabolized in the liver, with most of the drug converted into inactive metabolites. The main metabolic pathway involves the reduction of the ketone group on the oxandrolone molecule, which results in the formation of 17β-hydroxy-17α-methyl-5α-androstane-3-one (17β-OHMethyl-DHT).
Elimination and Excretion
oxandrolone and its metabolites are eliminated from the body primarily through urine, with a small amount being excreted in the feces. The elimination half-life of oxandrolone is approximately 9 hours, which means that it is cleared from the body relatively quickly compared to other anabolic steroids.
Administration:
oxandrolone is typically administered orally in the form of tablets. The dosing and administration of oxandrolone depend on the medical condition being treated and the individual patient’s age, weight, and overall health status. Here are some general guidelines for the administration of oxandrolone:
Patient information leaflet
Generic Name: oxandrolone
Pronounced: ox-AN-droe-lone
Why do we use oxandrolone?
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