- March 15, 2022
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Brand Name :
Aplenzin, Budeprion SR,Forfivo XL, Buproban, Wellbutrin SR, Wellbutrin XL, Zyban
Synonyms :
bupropion
Class :
Antidepressants and antianxiety drugs; Atypical antidepressants
Dosage forms & Strengths:
Adult:
Sustained release tablet:
100 mg
150 mg
200 mg
Extended-release tablet:
150 mg
300 mg
450 mg
150
mg
Orally
once a day
3
days
Tablet
15 - 45
mg
Orally
Once a day in the night
Tablet
Immediate release tablet-
100 mg orally every 12 hours. Increase the dose to 100 mg every 8 hours. If no clinical improvement is seen, maximize the dose up to 150 mg every 8 hours.
Sustained release tablet-
150 mg orally each day. Increase the dose to 150 mg every 12 hours. If no clinical improvement is seen, maximize the dose up to 150 mg every 12 hours.
Extended-release tablet-
150 mg orally each day. Increase the dose to 450 mg each day. If no clinical improvement is seen, maximize the dose up to 300 mg each day.
Aplenzin-
174 mg orally each day. Increase the dose after 4 days, to 348 mg. Do not increase the dose to more than 522 mg each day.
Forfivo XL-
450 mg orally each day
Can be utilized in patients who already are receiving 300 mg/day of bupropion
Immediate release tablet-
100 mg orally every 12 hours. Increase the dose to 100 mg every 8 hours. If no clinical improvement is seen, maximize the dose up to 150 mg every 8 hours.
Sustained release tablet-
150 mg orally each day. Increase the dose to 150 mg every 12 hours. If no clinical improvement is seen, maximize the dose up to 150 mg every 12 hours.
Extended-release tablet-
150 mg orally each day. Increase the dose to 450 mg each day. If no clinical improvement is seen, maximize the dose up to 300 mg each day.
Aplenzin-
174 mg orally each day. Increase the dose after 4 days, to 348 mg. Do not increase the dose to more than 522 mg each day.
Forfivo XL-
450 mg orally each day
Can be utilized in patients who already are receiving 300 mg/day of bupropion
Immediate-release tablet-
100 mg orally every 12 hours
Increase the dose to 100 mg every 8 hours
If no clinical improvement is seen, maximize the dose up to 150 mg every 8 hours
Sustained release tablet-
150 mg orally each day
Increase the dose to 150 mg every 12 hours
If no clinical improvement is seen, maximize the dose up to 150 mg every 12 hours
Extended-release tablet-
150 mg orally each day
Increase the dose to 150 mg every 12 hours after 3 weeks
If no clinical improvement is seen, maximize the dose by up to 300 mg each day
Aplenzin-
174 mg orally each day
Increase the dose after 4 days to 348 mg
Do not increase the dose to more than 522 mg each day
Forfivo XL-
450 mg orally each day
It can be utilized in patients who already are receiving 300 mg/day of bupropion
150 mg orally each day for 3 days
Increase the dose to 150 mg every 12 hours
Continue the treatment for up to 7-12 weeks
If successful quit occurs after 7-12 weeks, consider a maintenance therapy
Indicated for neuropathic pain
150 mg sustained-release bupropion orally twice daily for 6 weeks
attention-deficit/hyperactivity disorder (ADHD)
Initially, 150 mg/day orally
Standardize to 150-450 mg/day based on efficacy and tolerability
Administer as sustained or extended-release formulations
Dosage forms & Strengths:
Adult:
Tablet
75 mg
100 mg
Sustained release tablet
100 mg
150 mg
200 mg
Extended-release tablet
150 mg
300 mg
Extended-release tablet (Aplenzin)
174 mg
348 mg
522 mg
Extended-release tablet (Forfivo XL)
450 mg
attention-deficit/hyperactivity disorder (ADHD)
150
mg
Orally
once a day
Tablet
attention-deficit/hyperactivity disorder (ADHD)
(Off-Label)
Immediate-release
Initially, 3 mg/kg per day or 150 mg/day orally
Standardize to 6 mg/kg/day or a maximum of 300 mg each day
Do not exceed more than 150 mg
Extended-Release
Initially, 3 mg/kg per day or 150 mg/day orally
Standardize to 6 mg/kg/day or a maximum of 300 mg each day
Sustained-Release
Initially, 3 mg/kg per day or 150 mg/day orally
Standardize to 6 mg/kg/day or a maximum of 300 mg each day
Refer adult dosing
The risk of seizure may be increased.
it increases the effect of hypertension of bupropion
CYP2D6 Inhibitors increase the concentration of doxorubicin in serum
when both drugs are combined, there may be an increased risk of seizures
it increases the toxicity of norepinephrine reuptake inhibitors
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the toxicity of norepinephrine reuptake inhibitors
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the toxicity of norepinephrine reuptake inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
bupropion increases the toxicity of vilazodone
CYP2D6 Inhibitors increase the concentration of tamsulosin in serum
It may enhance the toxicity when combined with mipomersen
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
it may diminish the metabolism when combined with diosmin
Combining bupropion with pranlukast may cause a reduction in the bupropion’s metabolism
The potential for increased CNS depression risk or seriousness occurs when bupropion is used together with pipecuronium
When bupropion is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
bupropion has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When captodiame is used together with bupropion, There is a risk or seriousness of CNS depression is enhanced
When bupropion is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when bupropion is used together with fencamfamin
When bupropion is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When bupropion is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
If combined with pizotifen it may increase the neuroexcitatory or seizure-potentiating effect of bupropion
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
Action and spectrum:
The main action of bupropion is to inhibit the reuptake of dopamine and norepinephrine in the brain, which leads to an increase in their levels. This leads to an improvement in mood and a reduction in symptoms of depression. Bupropion also has a weak effect on the reuptake of serotonin, which is another chemical in the brain that plays a role in mood regulation.
The spectrum of bupropion includes its use as an antidepressant, as well as a smoking cessation aid. It is also sometimes used off-label to treat other conditions such as attention deficit hyperactivity disorder (ADHD) and seasonal affective disorder (SAD).
Frequency Defined
10%:
Headache
Nausea
Weight loss
Insomnia
Agitation
Dizziness
Pharyngitis
1-10%:
Constipation
Infection
Abdominal pain
Anxiety
Diarrhea
Tinnitus
Tremor
Nervousness
Anorexia
Palpitation
Myalgia
Sweating
Rash
Sinusitis
Weight gain
Chest pain
Urinary frequency
Vaginal hemorrhage
Pruritus
Vomiting
Arthralgia
Flushing
Migraine
Decreased memory
Irritability
Somnolence
Dysphagia
Arthritis
Paresthesia
Fever
<1%:
Mania
Grand mal seizure
Frequency undefined:
Confusion
Cystitis
Erythema
Ataxia
Coma
EEG abnormality
Euphoria
Gastric reflux
Black box warning:
The black box warning for bupropion, a medication used to treat depression, states that the drug can increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults up to the age of 24.
Contraindication/Caution
bupropion is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.
Pregnancy consideration:
bupropion should be used during pregnancy only when very much required
Breastfeeding warnings:
Use the drug cautiously during lactation.
Pregnancy category:
Pharmacology:
bupropion, also known by its brand name Wellbutrin, is a medication used to treat depression and seasonal affective disorder (SAD). It is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI) and works by increasing the levels of norepinephrine and dopamine in the brain.
Pharmacodynamics:
The mechanism of action of bupropion is thought to involve inhibition of the reuptake of norepinephrine and dopamine, which leads to an increase in the levels of these neurotransmitters in the brain. This increased availability of norepinephrine and dopamine is thought to improve mood and reduce symptoms of depression.
Pharmacokinetics:
Absorption
bupropion is rapidly absorbed with a peak serum time of 2 hours for the immediate-release formulation and 3 hours for the extended-release formulation. The medication is highly protein bound, with 84% binding to plasma proteins.
Distribution
Its volume of distribution (Vd) is between 20-47 L/kg
Metabolism
Metabolized in the liver by the enzyme CYP2B6
Elimination and excretion
The elimination half-life of bupropion ranges from 8-24 hours.The medication is primarily excreted in the urine (87%) and to a lesser extent in the feces (10%).
Administration:
Oral administration
bupropion is an antidepressant medication that is typically administered orally. The recommended dose of bupropion varies depending on the condition being treated and the individual patient. The usual starting dose for adults with depression is 150mg once a day, taken in the morning. The dose may be increased to 300mg once a day, usually after a minimum of 3 days.
Patient information leaflet
Generic Name: bupropion
Pronounced: bu-pro-pion
Why do we use bupropion?
bupropion is primarily prescribed to treat major depressive disorder (MDD), which is a condition characterized by persistent feelings of sadness, loss of interest or pleasure in daily activities, and other emotional and physical symptoms. It is also effective in managing seasonal affective disorder (SAD), a type of depression that occurs at certain times of the year, typically in the fall and winter when there is less natural sunlight.
bupropion can help individuals quit smoking. It works by reducing withdrawal symptoms and cravings associated with nicotine addiction. In some cases, bupropion may be used to aid in weight management or to prevent weight gain when quitting smoking. It is sometimes prescribed as an off-label treatment for ADHD, particularly in adults. It can help improve focus and attention. when bupropion combined with dextromethorphan used to provide rapid-acting oral treatment for MDD.
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